PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17252195-2	2007	Here, we show that upregulated Cyclin A/Cdk2 activity precedes the proteolytic cleavage of PARP and is correlated with the mitochondrial translocation of Bax and the loss of mitochondrial transmembrane potential (Deltapsim) during etoposide-induced apoptosis in human cervical adenocarcinoma (HeLa) cells.	Etoposide	231-240	cyclin A2	Homo sapiens	31-39	
23028682-4	2012	Cyclin A-Cdk2 catalyzed the phosphorylation of Rad9 at serine 328 in HeLa cells during apoptosis induced by etoposide, an inhibitor of topoisomeraseII.	Etoposide	108-117	cyclin A2	Homo sapiens	0-8	
17636382-0	2007	New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis.	Etoposide	130-139	cyclin A2	Homo sapiens	71-79	
17636382-0	2007	New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis.	Etoposide	167-176	cyclin A2	Homo sapiens	71-79	
28542143-4	2017	Importantly, E2F1 stabilization in response to etoposide-induced DNA damage or during the S phase of cell cycle, as revealed by cyclin A silencing, is associated with K63-poly-ubiquitinylation of E2F1 on lysine 161/164 residues and involves cIAP1.	Etoposide	47-56	cyclin A2	Homo sapiens	128-136	
17252195-5	2007	Disruption of the mitochondrial transmembrane potential in etoposide-induced cells is prevented in cells that overexpress Cdk2-dn or p21(WAF1/CIP1), while this transition is prominently promoted in Cyclin A-expressing cells.	Etoposide	59-68	cyclin A2	Homo sapiens	198-206	
9054953-10	1997	The potentiation of etoposide-induced apoptosis by staurosprine was associated with a significant increase in cyclin A-dependent kinase activity.	Etoposide	20-29	cyclin A2	Homo sapiens	110-118	
12677090-11	2002	Ad-E2F-1 treatment alone results in 3.4-fold increase of cyclin A kinase activity compared to Ad-LacZ control (p < 0.05); when combined with chemotherapeutic agents, cyclin A kinase activity was inhibited significantly by VIN, actinomycin D, and etoposide (p < 0.005), but not with CPT, CIS, and 5-FU (p > 0.1) compared to Ad-E2F-1 treatment alone.	Etoposide	249-258	cyclin A2	Homo sapiens	57-65	
12677090-11	2002	Ad-E2F-1 treatment alone results in 3.4-fold increase of cyclin A kinase activity compared to Ad-LacZ control (p < 0.05); when combined with chemotherapeutic agents, cyclin A kinase activity was inhibited significantly by VIN, actinomycin D, and etoposide (p < 0.005), but not with CPT, CIS, and 5-FU (p > 0.1) compared to Ad-E2F-1 treatment alone.	Etoposide	249-258	cyclin A2	Homo sapiens	169-177	
17390037-0	2007	Expression of cyclin A in human leukemia cell line HL-60 following treatment with doxorubicin and etoposide: the potential involvement of cyclin A in apoptosis.	Etoposide	98-107	cyclin A2	Homo sapiens	14-22	
17390037-1	2007	We investigated expression of cyclin A in HL-60 cells after induction of apoptosis with doxorubicin and etoposide.	Etoposide	104-113	cyclin A2	Homo sapiens	30-38	
17390037-5	2007	Cells treated with lower doses of doxorubicin and etoposide as well as the untreated cells were found to have cyclin A scattered mainly throughout the nucleus.	Etoposide	50-59	cyclin A2	Homo sapiens	110-118	
17390037-6	2007	However, immunogold labeling of cyclin A in both cell lines treated with 5- and 10-microM doses of doxorubicin, and 20 and 200 microM of etoposide was observed more often in the cytoplasm than in the nucleus.	Etoposide	137-146	cyclin A2	Homo sapiens	32-40