PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21423217-0	2011	Bid can mediate a pro-apoptotic response to etoposide and ionizing radiation without cleavage in its unstructured loop and in the absence of p53.	Etoposide	44-53	BH3 interacting domain death agonist	Mus musculus	0-3	
21423217-4	2011	Bid has also been implicated in the apoptotic response to ionizing radiation (IR) and the topoisomerase inhibitor etoposide, anti-cancer regimens that cause double-strand (ds)DNA breaks.	Etoposide	114-123	BH3 interacting domain death agonist	Mus musculus	0-3	
21423217-7	2011	We used Bid-deficient mouse embryonic fibroblast (MEF) lines that were reconstituted with Bid to control the cellular background and demonstrated that the Bid-dependent apoptotic pathway induced by IR and etoposide operates in MEFs that are transformed by SV40, but is not evident in E1A/Ras-transformed MEFs.	Etoposide	205-214	BH3 interacting domain death agonist	Mus musculus	8-11	
21423217-7	2011	We used Bid-deficient mouse embryonic fibroblast (MEF) lines that were reconstituted with Bid to control the cellular background and demonstrated that the Bid-dependent apoptotic pathway induced by IR and etoposide operates in MEFs that are transformed by SV40, but is not evident in E1A/Ras-transformed MEFs.	Etoposide	205-214	BH3 interacting domain death agonist	Mus musculus	90-93	
21423217-7	2011	We used Bid-deficient mouse embryonic fibroblast (MEF) lines that were reconstituted with Bid to control the cellular background and demonstrated that the Bid-dependent apoptotic pathway induced by IR and etoposide operates in MEFs that are transformed by SV40, but is not evident in E1A/Ras-transformed MEFs.	Etoposide	205-214	BH3 interacting domain death agonist	Mus musculus	90-93	
21423217-9	2011	In these cells, Bid acted in a conventional manner in that it required its BH3 domain to mediate apoptosis in response to IR and etoposide, and triggered apoptotic execution by indirect activation of Bak/Bax, mitochondrial permeabilization and caspase-9 activation.	Etoposide	129-138	BH3 interacting domain death agonist	Mus musculus	16-19	
21423217-10	2011	However, the mechanism of Bid activation was unconventional, because elimination of all known or suspected cleavage sites for caspases or other proteolytic enzymes and even complete elimination of its unstructured cleavage loop left Bid"s pro-apoptotic role in the response to IR and etoposide unaffected.	Etoposide	284-293	BH3 interacting domain death agonist	Mus musculus	26-29	
16122426-5	2005	In contrast, introducing a nonphosphorylatable BID mutant did not restore accumulation in the S phase and resulted in an increase in cellular sensitivity to etoposide-induced apoptosis.	Etoposide	157-166	BH3 interacting domain death agonist	Mus musculus	47-50