PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28716816-4	2017	Targeting S1PR1 by shRNA markedly enhances etoposide-induced apoptosis in NB cells and abrogates EMDR, while overexpression of S1PR1 significantly protects NB cells from multidrug-induced apoptosis via activating JAK-STAT3 signaling.	Etoposide	43-52	sphingosine-1-phosphate receptor 1	Homo sapiens	10-15	
28716816-5	2017	Elevated S1PR1 expression and STAT3 activation are also observed in human NB cells with acquired resistance to etoposide.	Etoposide	111-120	sphingosine-1-phosphate receptor 1	Homo sapiens	9-14	
28716816-6	2017	We show in vitro and in human NB xenograft models that treatment with FTY720, an FDA-approved drug and antagonist of S1PR1, dramatically sensitizes drug-resistant cells to etoposide.	Etoposide	172-181	sphingosine-1-phosphate receptor 1	Homo sapiens	117-122