PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15548330-8	2004	In addition, prosaptide TX14A, saposin C, or prosaposin decreased the growth-inhibitory effect, caspase-3/7 activity, and apoptotic cell death induced by etoposide.	Etoposide	154-163	caspase 3	Mus musculus	96-105	
15868939-0	2005	Involvement of Bax, Bcl-2 and caspase 3 in hydroxyurea- or etoposide-induced apoptosis of mouse interleukin-3-dependent lymphoma cells.	Etoposide	59-68	caspase 3	Mus musculus	30-39	
14646211-6	2003	Beta-Cx inhibited the etoposide-induced activation of caspase-3 activity in a dose-dependent manner.	Etoposide	22-31	caspase 3	Mus musculus	54-63	
11449356-6	2001	Etoposide-induced expression of the cleaved, proteolytically active form of caspase 3, and DEVD-ase activity, detected prior to nuclear damage, were blocked in the presence of calpain inhibitors.	Etoposide	0-9	caspase 3	Mus musculus	76-85	
11391533-11	2001	Etoposide treatment reduced CPP32/caspase-3 activity in the liver, although it did not alter the serum TNF-alpha levels or hepatic TNFR1 mRNA expressions.	Etoposide	0-9	caspase 3	Mus musculus	28-33	
11391533-11	2001	Etoposide treatment reduced CPP32/caspase-3 activity in the liver, although it did not alter the serum TNF-alpha levels or hepatic TNFR1 mRNA expressions.	Etoposide	0-9	caspase 3	Mus musculus	34-43	
10442630-3	1999	When human Jurkat cells were exposed to etoposide, or UV or gamma radiation, a caspase-3-like protease was activated, and nuclear DNA was fragmented.	Etoposide	40-49	caspase 3	Mus musculus	79-88	
11256964-6	2001	The lack of spermine did not affect the expression of Bcl-2, and caspases 3 and 9 were activated by etoposide in both N and Gy cells, indicating that spermine is dispensable for caspase activation.	Etoposide	100-109	caspase 3	Mus musculus	65-81	
22117068-3	2012	Etoposide-induced death of MLO-Y4 osteocyte-like cells, assessed by trypan blue staining, caspase-3 cleavage, and TUNEL assays, was completely prevented when cells were pre-treated with 17beta-estradiol.	Etoposide	0-9	caspase 3	Mus musculus	90-99	
31818176-7	2020	Using etoposide-induced primary cortical neurons injury model, we found that miR-23a was decreased in this cell model and miR-23a overexpression-suppressed etoposide induced the activity of caspase 3 and the releases of inflammatory mediators in primary cortical neurons.	Etoposide	6-15	caspase 3	Mus musculus	190-199	
31818176-7	2020	Using etoposide-induced primary cortical neurons injury model, we found that miR-23a was decreased in this cell model and miR-23a overexpression-suppressed etoposide induced the activity of caspase 3 and the releases of inflammatory mediators in primary cortical neurons.	Etoposide	156-165	caspase 3	Mus musculus	190-199	
25215539-8	2014	Upon stimulation by DNA-damaging drug etoposide in vitro, mutant B cells showed increased cleavage of caspase 3.	Etoposide	38-47	caspase 3	Mus musculus	102-111	
23430060-7	2013	GP7 or etoposide induced sub-G(1) peak, apoptotic DNA fragmentation, activations of caspase-3, -8, -9, and DNA fragmentation factor, downregulation of Bcl-2 and Bcl-xL, upregulation of Bax and Bak, and cytochrome-c release from mitochondria in both mouse and human OS cells.	Etoposide	7-16	caspase 3	Mus musculus	84-101	
16651419-4	2006	Furthermore, PAF inhibited etoposide-induced increases in caspase-3, caspase-8, and caspase-9 activities, as well as cell death.	Etoposide	27-36	caspase 3	Mus musculus	58-67	
19408126-0	2009	Glycogen synthase kinase-3beta regulates etoposide-induced apoptosis via Bcl-2 mediated caspase-3 activation in C3H10T1/2 cells.	Etoposide	41-50	caspase 3	Mus musculus	88-97	
19408126-4	2009	Etoposide led to the time-dependent activation of GSK3beta and caspase-3, which resulted in PARP cleavage.	Etoposide	0-9	caspase 3	Mus musculus	63-72	
19408126-9	2009	In conclusion, etoposide-induced apoptosis in C3H10T1/2 cells is mediated by GSK3beta, which leads to caspase-3 activation via decrease in Bcl-2 expression.	Etoposide	15-24	caspase 3	Mus musculus	102-111