PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21503882-7 2012 Finally, Gleevec (STI571) a pharmacological inhibitor of p73, a master gene controlling apoptosis induced by etoposide, prevented the increase of TACE/ADAM17 levels. Etoposide 109-118 tumor protein p73 Rattus norvegicus 57-60 20519366-0 2010 p73 participates in male germ cells apoptosis induced by etoposide. Etoposide 57-66 tumor protein p73 Rattus norvegicus 0-3 20519366-3 2010 The aim of this study was to evaluate the participation of p73, a member of the p53 family, in apoptosis induced by etoposide in male germ cells. Etoposide 116-125 tumor protein p73 Rattus norvegicus 59-62 20519366-5 2010 We found an important increase in p73 protein levels, along with the c-Abl kinase, its physiological activator, in response to etoposide. Etoposide 127-136 tumor protein p73 Rattus norvegicus 34-37 20519366-8 2010 Also, the in vitro knockdown of p73 or p53 by shRNA, significantly prevented the decrease in cell viability after etoposide treatment. Etoposide 114-123 tumor protein p73 Rattus norvegicus 32-35 20519366-9 2010 In an in vivo model-21-day-old rat testes-we observed an up-regulation of the protein levels of p73 and phosphorylated p73-at c-Abl site Tyr99-in response to the etoposide injection. Etoposide 162-171 tumor protein p73 Rattus norvegicus 96-99 20519366-9 2010 In an in vivo model-21-day-old rat testes-we observed an up-regulation of the protein levels of p73 and phosphorylated p73-at c-Abl site Tyr99-in response to the etoposide injection. Etoposide 162-171 tumor protein p73 Rattus norvegicus 119-122 20519366-10 2010 STI571 (a pharmacological inhibitor of c-Abl) or PFT co-injection prevented etoposide-induced up-regulation of phospho-p73 and pro-apoptotic TAp73 isoform levels. Etoposide 76-85 tumor protein p73 Rattus norvegicus 119-122 20519366-12 2010 These results support the notion that the c-Abl/p73 pathway is activated in germ cells after etoposide treatment, triggering apoptosis, possibly assisting p53. Etoposide 93-102 tumor protein p73 Rattus norvegicus 48-51