PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28185889-0	2017	MicroRNA hsa-miR-29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1.	Etoposide	33-42	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	89-94	
34305242-0	2021	Knockdown of Myeloid Cell Leukemia-1 by MicroRNA-101 Increases Sensitivity of A549 Lung Cancer Cells to Etoposide.	Etoposide	104-113	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	13-36	
29113504-8	2018	Besides, combined treatment of etoposide with Mcl-1 and Survivin siRNAs co-transfection leads to synergistically enhance etoposide-induced cytotoxic and apoptotic effects (p < .05).	Etoposide	121-130	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	46-51	
29113504-9	2018	The results showed that Mcl-1 and Survivin play a major role in the U937 cells survival and their resistance relative to etoposide.	Etoposide	121-130	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	24-29	
28947136-2	2018	Here, we report that BH3 mimetics selectively targeting BCL-xL, BCL-2 or MCL-1 (i.e. A-1331852, ABT-199, A-1210477) act in concert with multiple chemotherapeutic agents (i.e. vincristine (VCR), etoposide (ETO), doxorubicin, actinomycin D and cyclophosphamide) to induce apoptosis in rhabdomyosarcoma (RMS) cells.	Etoposide	194-203	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	73-78	
28947136-2	2018	Here, we report that BH3 mimetics selectively targeting BCL-xL, BCL-2 or MCL-1 (i.e. A-1331852, ABT-199, A-1210477) act in concert with multiple chemotherapeutic agents (i.e. vincristine (VCR), etoposide (ETO), doxorubicin, actinomycin D and cyclophosphamide) to induce apoptosis in rhabdomyosarcoma (RMS) cells.	Etoposide	205-208	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	73-78	
28185889-6	2017	Because Mcl-1 protein has been recognized as a miR-29 family target, we evaluated downregulation of Mcl-1 protein splicing variant expression induced by miR-29 precursors and confirmed a key role of Mcl-1 protein in enhancing etoposide toxicity.	Etoposide	226-235	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	8-13	
28185889-11	2017	In conclusion, we show that miR-29b has the synergistic effect with etoposide treatment in the HeLa cells and that this effect is linked to Mcl-1 protein expression and nuclear shuttling of miR-29b.	Etoposide	68-77	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	140-145	
24568469-0	2014	Down-regulation of Mcl-1 by small interference RNA induces apoptosis and sensitizes HL-60 leukemia cells to etoposide.	Etoposide	108-117	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	19-24	
26727221-8	2016	These results demonstrate the importance of GSK-3beta and caspase-2 in ceramide- and etoposide-induced apoptosis through mechanisms involving Mcl-1 destabilization and the lysosomal-mitochondrial axis.	Etoposide	85-94	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	142-147	
27166195-2	2016	We show here that the DNA damaging agents cisplatin and etoposide upregulate Noxa expression, which is required for the phosphorylation of MCL-1 at Ser64/Thr70 sites, proteasome-dependent degradation, and apoptosis.	Etoposide	56-65	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	139-144	
24568469-12	2014	Furthermore, Mcl-1 down-regulation significantly increased apoptosis sensitivity to etoposide.	Etoposide	84-93	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	13-18	
20189983-9	2010	Bcl-2- and Mcl-1-mediated protection from apoptosis induced by staurosporine or etoposide was enhanced in cells expressing InsP(3)R, demonstrating that their interactions with InsP(3)R enable Bcl-2 and Mcl-1 to be fully efficacious anti-apoptotic mediators.	Etoposide	80-89	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	11-16	
23124518-3	2012	In addition, sequential treatment with etoposide and TRAIL increased caspases 8, 9 and 3 activation, Mcl-1 cleavage and Bid truncation, which suggests that the ability of etoposide and TRAIL to induce apoptosis is mediated through activation of an intrinsic signalling pathway.	Etoposide	39-48	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	101-106	
23124518-3	2012	In addition, sequential treatment with etoposide and TRAIL increased caspases 8, 9 and 3 activation, Mcl-1 cleavage and Bid truncation, which suggests that the ability of etoposide and TRAIL to induce apoptosis is mediated through activation of an intrinsic signalling pathway.	Etoposide	171-180	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	101-106	
19246337-9	2009	Treatment with cisplatin or etoposide, alone or in combination with ABT-737, resulted in substantial down-regulation of Mcl-1L, a known inhibitor of ABT-737 action.	Etoposide	28-37	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	120-126	
10556359-8	1999	Viabilities of control and mcl-1 transfected cells after treatment with the cytotoxin etoposide (20 microgram/ml), were 37.9 +/- 3.9% and 78.2 +/- 2.0%, respectively.	Etoposide	86-95	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	27-32	
18495871-2	2008	Increased expression of nuclear Mcl-1 and/or a previously reported short nuclear form of Mcl-1, snMcl-1, was observed in response to treatment with low concentrations of etoposide or low doses of UV irradiation.	Etoposide	170-179	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	32-37	
18495871-2	2008	Increased expression of nuclear Mcl-1 and/or a previously reported short nuclear form of Mcl-1, snMcl-1, was observed in response to treatment with low concentrations of etoposide or low doses of UV irradiation.	Etoposide	170-179	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	89-94	
18495871-3	2008	We showed that after etoposide treatment, Mcl-1 could coimmunoprecipitate with the regulatory kinase, Chk1.	Etoposide	21-30	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	42-47	
16467098-6	2006	Using antisense oligonucleotides against Mcl-1, MDA-MB-231 cells were rendered sensitive to etoposide-induced apoptosis similar to herceptin, but combined treatment of antisense against Mcl-1 and herceptin failed to give a significant increase in apoptosis.	Etoposide	92-101	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	41-46	
16467098-6	2006	Using antisense oligonucleotides against Mcl-1, MDA-MB-231 cells were rendered sensitive to etoposide-induced apoptosis similar to herceptin, but combined treatment of antisense against Mcl-1 and herceptin failed to give a significant increase in apoptosis.	Etoposide	92-101	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	186-191	
10978339-8	2000	In contrast, MCL1(Delta)(4A) retained its anti-apoptotic function in HeLa cells when challenged by Etoposide.	Etoposide	99-108	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	13-17	
10381626-2	1999	Exposure of undifferentiated U937 cells to 50 microM etoposide for 6 h, that triggers apoptosis in 80% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Mcl-1 expression without modifying Bcl-2, Bcl-xL and Bax protein levels.	Etoposide	53-62	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	210-215	
9850095-6	1998	MCL1 decreased the caspase 3 activity induced by exposure to etoposide and increased the viability of the transfected cells after etoposide exposure.	Etoposide	61-70	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	0-4	
9850095-6	1998	MCL1 decreased the caspase 3 activity induced by exposure to etoposide and increased the viability of the transfected cells after etoposide exposure.	Etoposide	130-139	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	0-4	
9281370-4	1997	The increase in Mcl-1 protein levels correlates with a reduced extent of apoptotic cell death induced by etoposide or the calcium ionophore A23187.	Etoposide	105-114	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	16-21	
9281370-5	1997	The Mcl-1 protein is primarily localized in the mitochondria, and etoposide- or A23187-induced cytochrome c release is reduced in cells in which the mitochondria contain the Mcl-1 protein demonstrable by immunoblots.	Etoposide	66-75	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	174-179