PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29133590-2 2018 In this study, etoposide activates the alpha1 but not the alpha2 isoform of AMPK, primarily within the nucleus. Etoposide 15-24 adrenoceptor alpha 1D Homo sapiens 39-45 29133590-6 2018 These results suggest that AMPK activation protects cells against etoposide by limiting entry into S-phase, where cells would be more vulnerable to genotoxic stress.Implications: These results reveal that the alpha1 isoform of AMPK promotes tumorigenesis by protecting cells against genotoxic stress, which may explain findings that the gene encoding AMPK-alpha1 (but not -alpha2) is amplified in some human cancers. Etoposide 66-75 adrenoceptor alpha 1D Homo sapiens 209-215