PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24606760-7 2014 TCTP antagonized the mitochondria-dependent apoptotic pathway following etoposide treatment, including mitochondrial membrane damage and resultant cytochrome c release, activation of caspase-9, and -3, and eventually, the cleavage of EGFR and PLC-gamma. Etoposide 72-81 cytochrome c, somatic Homo sapiens 147-159 30797456-8 2019 In addition, this strategy was successfully applied for quantitative detection of Cyt c in cell lysates of H2O2 or etoposide (anticancer drug)-induced apoptotic cells, providing great potential application for cell-based oxidation pressure determination and screening of anticancer drugs. Etoposide 115-124 cytochrome c, somatic Homo sapiens 82-87 29467390-7 2018 Etoposide and cisplatin induced mitochondrial depolarization, cytochrome c release and caspase activation in COV434 cells. Etoposide 0-9 cytochrome c, somatic Homo sapiens 62-74 27619527-7 2017 In addition, the UCNP@PDA@AP has been successfully used to monitor etoposide induced intracellular releasing of Cyt c, providing the possibility for cell-based screening of apoptosis-inducing drugs. Etoposide 67-76 cytochrome c, somatic Homo sapiens 112-117 26424010-4 2015 SPATA4 protected HeLa cells from etoposide-induced apoptosis through the mitochondrial apoptotic pathway, in the way that SPATA4 suppressed decrease of the mitochondrial membrane potential, the release of cytochrome c, and subsequent activation of caspase-9 and -3. Etoposide 33-42 cytochrome c, somatic Homo sapiens 205-217 20174550-8 2010 Ats-1 inhibited etoposide-induced cytochrome c release from mitochondria, PARP cleavage, and apoptosis in mammalian cells, as well as Bax-induced yeast apoptosis. Etoposide 16-25 cytochrome c, somatic Homo sapiens 34-46 20576107-6 2010 At the level of mitochondria, etoposide-treatment had a similar sensitizing activity and allowed for ABT-737-induced release of cytochrome c. Etoposide 30-39 cytochrome c, somatic Homo sapiens 128-140 18492488-4 2008 MG132 and ALLN inhibited the release of cytochrome c from mitochondria into the cytosol in the absence of survival factors and suppressed the cleavage of pro-caspase-9 and -3 to its active forms induced by etoposide. Etoposide 206-215 cytochrome c, somatic Homo sapiens 40-52 18330707-5 2008 ISG12a enhanced etoposide induced cytochrome c release, Bax activation and loss of mitochondrial membrane potential. Etoposide 16-25 cytochrome c, somatic Homo sapiens 34-46 17174951-4 2007 Etoposide treatment resulted in an early upregulation of Fas and cytoplasmic release of mitochondrial cytochrome c. Etoposide 0-9 cytochrome c, somatic Homo sapiens 102-114 18258603-2 2008 Our previous study demonstrated that silencing of the AChE gene blocked the interaction between cytochrome c and apoptotic protease-activating factor-1 (Apaf-1) in etoposide-induced apoptosis of HT-29 cells. Etoposide 164-173 cytochrome c, somatic Homo sapiens 96-108 16690782-6 2006 We further show that etoposide can inhibit cytochrome c-catalyzed oxidation of cardiolipin competing with it as a peroxidase substrate. Etoposide 21-30 cytochrome c, somatic Homo sapiens 43-55 16690782-4 2006 Here, we demonstrate that cardiolipin oxidation during apoptosis is realized not via a random cardiolipin peroxidation mechanism but rather proceeds as a result of peroxidase reaction in a tight cytochrome c/cardiolipin complex that restrains interactions of etoposide with radical intermediates generated in the course of the reaction. Etoposide 259-268 cytochrome c, somatic Homo sapiens 195-207 15388581-4 2005 Ectopic expression of hsp70 in HL-60 cells (HL-60/hsp70) inhibited Ara-C and etoposide-induced Bax conformation change and translocation to the mitochondria; attenuated the accumulation of cytochrome c, Smac, and Omi/HtrA2 in the cytosol; and inhibited the processing and activity of caspase-9 and caspase-3. Etoposide 77-86 cytochrome c, somatic Homo sapiens 189-201 16202244-0 2005 Release of cytochrome c from isolated mitochondria by etoposide. Etoposide 54-63 cytochrome c, somatic Homo sapiens 11-23 16202244-4 2005 Further, we provide the evidence that etoposide can induce the cytochrome c release from isolated mitochondria, and etoposide-induced cytochrome c release is not accompanied with the large amplitude swelling of mitochondria. Etoposide 38-47 cytochrome c, somatic Homo sapiens 63-75 16202244-4 2005 Further, we provide the evidence that etoposide can induce the cytochrome c release from isolated mitochondria, and etoposide-induced cytochrome c release is not accompanied with the large amplitude swelling of mitochondria. Etoposide 116-125 cytochrome c, somatic Homo sapiens 134-146 16543234-8 2006 Interaction of NO with the cyt c.CL complex inhibited its peroxidase activity with three different substrates: CL, etoposide, and 3,3"-diaminobenzidine. Etoposide 115-124 cytochrome c, somatic Homo sapiens 27-32 12121973-8 2002 Treatment of NCI-H82 cells with etoposide induces a series of time-dependent events, including the release of cytochrome c from the mitochondria to the cytosol, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP). Etoposide 32-41 cytochrome c, somatic Homo sapiens 110-122 15455353-4 2005 LMP1 also potentiates etoposide-induced processing and activation of caspase-2 in this model and enhances the dissipation of mitochondrial transmembrane potential and the release of cytochrome c in response to etoposide. Etoposide 210-219 cytochrome c, somatic Homo sapiens 182-194 15242764-8 2004 Upon engagement of the mitochondrial pathway of apoptosis, etoposide provoked cytosolic accumulation of Smac along with cytochrome c and loss of the mitochondrial membrane potential. Etoposide 59-68 cytochrome c, somatic Homo sapiens 120-132 12702731-5 2003 While staurosporine, H7, etoposide, and chelerythrine released cytochrome c from mitochondria in intact cells, only chelerythrine released cytochrome c from isolated mitochondria. Etoposide 25-34 cytochrome c, somatic Homo sapiens 63-75 12605597-4 2003 Indeed, using Jurkat cells as a model system, we demonstrate that NO donors block Fas- and etoposide-induced caspase activation and apoptosis (downstream of mitochondrial membrane depolarization) and cytochrome c release. Etoposide 91-100 cytochrome c, somatic Homo sapiens 200-212 12907245-4 2003 Vinblastine, doxorubicin, or etoposide (VP-16) induced apoptotic cell death in KB-3 carcinoma cells, with similar kinetic profiles of PARP cleavage, caspase 3 activation, and mitochondrial cytochrome c release. Etoposide 29-38 cytochrome c, somatic Homo sapiens 189-201 12065594-0 2002 Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. Etoposide 79-88 cytochrome c, somatic Homo sapiens 51-63 12065594-3 2002 We demonstrate here a role for caspase-2 in etoposide-induced cytochrome c release. Etoposide 44-53 cytochrome c, somatic Homo sapiens 62-74 12065594-5 2002 Experiments performed using a reconstituted cell-free system indicate that etoposide-induced cytochrome c release by way of caspase-2 occurs independently of cytosolic factors, suggesting that the nuclear pool of pro-caspase-2 is critical to this process. Etoposide 75-84 cytochrome c, somatic Homo sapiens 93-105 12060385-4 2002 Etoposide and cisplatin induced apoptosis in drug-sensitive MeWo cells as indicated by dose-dependent (i) cytochrome c release, (ii) caspase activation, (iii) DNA fragmentation, and (iv) cleavage of poly(ADP-ribose)polymerase. Etoposide 0-9 cytochrome c, somatic Homo sapiens 106-118 11513857-6 2001 However, subsequent exposure of CCCP-treated cells to etoposide or staurosporine for 48 h results in rapid cell death and cytochrome c release that is accompanied by Bax association with mitochondria, demonstrating competency of these mitochondria to release cytochrome c with additional triggers. Etoposide 54-63 cytochrome c, somatic Homo sapiens 122-134 11864976-0 2002 The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. Etoposide 14-23 cytochrome c, somatic Homo sapiens 108-120 11864976-1 2002 Treatment of L929 fibroblasts by the topoisomerase II inhibitor etoposide killed 50% of the cells within 72 h. The cell killing was preceded by the release of cytochrome c from the mitochondria. Etoposide 64-73 cytochrome c, somatic Homo sapiens 159-171 16120290-1 2002 During etoposide-induced apoptosis in HL-60 cells, cytochrome c release was associated with mitochondrial swelling caused by increased mitochondrial potassium uptake. Etoposide 7-16 cytochrome c, somatic Homo sapiens 51-63 11784858-15 2002 Moreover, in etoposide-treated cells, Hsp27 still delayed the release of cytochrome c from mitochondria and Bid intracellular redistribution in conditions where F-actin was not altered. Etoposide 13-22 cytochrome c, somatic Homo sapiens 73-85 11513857-6 2001 However, subsequent exposure of CCCP-treated cells to etoposide or staurosporine for 48 h results in rapid cell death and cytochrome c release that is accompanied by Bax association with mitochondria, demonstrating competency of these mitochondria to release cytochrome c with additional triggers. Etoposide 54-63 cytochrome c, somatic Homo sapiens 259-271 10961984-0 2000 Distinct pathways for stimulation of cytochrome c release by etoposide. Etoposide 61-70 cytochrome c, somatic Homo sapiens 37-49 11431014-5 2001 Apoptosis was induced by etoposide, which induces mitochondria-dependent apoptosis through the release of cytochrome c from the mitochondria. Etoposide 25-34 cytochrome c, somatic Homo sapiens 106-118 10961984-1 2000 Induction of apoptosis by DNA-damaging agents, such as etoposide, is known to involve the release of mitochondrial cytochrome c, although the mechanism responsible for this event is unclear. Etoposide 55-64 cytochrome c, somatic Homo sapiens 115-127 10961984-2 2000 In the present study, using Jurkat T-lymphocytes, a reconstituted cell-free system, or isolated liver mitochondria, we demonstrate the ability of etoposide to induce cytochrome c release via two distinct pathways. Etoposide 146-155 cytochrome c, somatic Homo sapiens 166-178 10961984-7 2000 We propose that lower doses of etoposide predominantly target the nucleus and stimulate the release of caspase-sensitive protein factor(s) that interact with mitochondria to trigger cytochrome c release, whereas higher doses of the drug impart a more direct effect on mitochondria and thus are not mitigated by caspase inhibition. Etoposide 31-40 cytochrome c, somatic Homo sapiens 182-194 11029754-7 2000 Pretreatment with a specific calpain inhibitor calpeptin inhibited etoposide-induced calpain activation, Bax cleavage, cytochrome c release, and caspase-3 activation. Etoposide 67-76 cytochrome c, somatic Homo sapiens 119-131 11029754-10 2000 Finally, Bcl-2 overexpression inhibited etoposide-induced calpain activation, Bax cleavage, cytochrome c release, and apoptosis. Etoposide 40-49 cytochrome c, somatic Homo sapiens 92-104 10713737-2 2000 By investigating the ordering of molecular events during genotoxic stress-induced apoptosis, we found that ionizing radiation (IR) and etoposide induced the release of cyto c from mitochondria in two distinct stages. Etoposide 135-144 cytochrome c, somatic Homo sapiens 168-174 11042671-3 2000 Etoposide induced increased formation of ceramide from sphingomyelin and release of mitochondrial cytochrome c followed by activation of caspase-9 and caspase-3, but not caspase-1. Etoposide 0-9 cytochrome c, somatic Homo sapiens 98-110 11042671-9 2000 Taken together, these results suggest that ceramide may function as a mediator of etoposide-induced apoptosis of C6 glioma cells, which induces increase in the Bax/Bcl-2 ratio followed by release of cytochrome c leading to caspases-9 and -3 activation. Etoposide 82-91 cytochrome c, somatic Homo sapiens 199-211 10918609-3 2000 Etoposide, cisplatin and tumor necrosis factor-alpha induced apoptosis of C6 rat glioma cells which was associated with ceramide formation due to activation of neutral sphingomyelinase, followed by release of mitochondrial cytochrome c into the cytosol and activation of caspases-9 and -3. Etoposide 0-9 cytochrome c, somatic Homo sapiens 223-235 10918609-5 2000 Bax overexpression enhanced etoposide-induced apoptosis through acceleration of cytochrome c release and caspases activation. Etoposide 28-37 cytochrome c, somatic Homo sapiens 80-92 10050878-5 1999 Exposure of mock-transfected U937 cells to 50 microm etoposide activates procaspase-3 and the long isoform of procaspase-2 and induces mitochondrial potential decrease and cytochrome c release from mitochondria to the cytosol. Etoposide 53-62 cytochrome c, somatic Homo sapiens 172-184 10544189-9 1999 We conclude that HSP27 inhibits etoposide-induced apoptosis by preventing cytochrome c and dATP-triggered activity of caspase-9, downstream of cytochrome c release. Etoposide 32-41 cytochrome c, somatic Homo sapiens 74-86 10544189-9 1999 We conclude that HSP27 inhibits etoposide-induced apoptosis by preventing cytochrome c and dATP-triggered activity of caspase-9, downstream of cytochrome c release. Etoposide 32-41 cytochrome c, somatic Homo sapiens 143-155 10381626-2 1999 Exposure of undifferentiated U937 cells to 50 microM etoposide for 6 h, that triggers apoptosis in 80% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Mcl-1 expression without modifying Bcl-2, Bcl-xL and Bax protein levels. Etoposide 53-62 cytochrome c, somatic Homo sapiens 183-195 10454539-6 1999 In addition, A1 potently inhibited etoposide-induced apoptosis by inhibiting the release of cytochrome c and by blocking caspase 3 activation. Etoposide 35-44 cytochrome c, somatic Homo sapiens 92-104 35614109-4 2022 Apigenin when combined with etoposide or cyclophosphamide-induced apoptosis via the mitochondrial pathway, increasing the expression of pro-apoptotic cytochrome c, SMAC/DIABLO, and HTRA2/OMI, which promoted caspase-9 and -3 activation. Etoposide 28-37 cytochrome c, somatic Homo sapiens 150-162 9473236-5 1998 Exposure of the control AML HL-60 cells to high-dose Ara-C (HIDAC), etoposide, or sphingoid bases (including C2 ceramide, sphingosine, or sphinganine) caused the accumulation of cyt c in the cytosol, loss of mitochondrial membrane potential (MMP), and increase in the reactive oxygen species (ROS). Etoposide 68-77 cytochrome c, somatic Homo sapiens 178-183 9373239-9 1997 Collectively, these results suggest that a delay in the signaling cascade upstream of cytochrome c release and caspase activation leads to a long latent period before the active phase of apoptosis is initiated in etoposide-treated K562 cells. Etoposide 213-222 cytochrome c, somatic Homo sapiens 86-98 9281370-5 1997 The Mcl-1 protein is primarily localized in the mitochondria, and etoposide- or A23187-induced cytochrome c release is reduced in cells in which the mitochondria contain the Mcl-1 protein demonstrable by immunoblots. Etoposide 66-75 cytochrome c, somatic Homo sapiens 95-107