PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24695317-0 2014 The SUMO-targeted ubiquitin ligase RNF4 localizes to etoposide-exposed mitotic chromosomes: implication for a novel DNA damage response during mitosis. Etoposide 53-62 ring finger protein 4 Homo sapiens 35-39 24695317-3 2014 Here we showed that administration of etoposide, an anticancer DNA topoisomerase II poison, to mitotic human cervical cancer HeLa cells induced SUMO-2/3-dependent localization of RNF4 to chromosomes. Etoposide 38-47 ring finger protein 4 Homo sapiens 179-183 24695317-5 2014 This suggests that RNF4 functions as a STUbL in the etoposide-induced damage response during mitosis. Etoposide 52-61 ring finger protein 4 Homo sapiens 19-23 24695317-6 2014 Indeed, RNF4-depletion sensitized mitotic HeLa cells to etoposide and increased cells with micronuclei. Etoposide 56-65 ring finger protein 4 Homo sapiens 8-12