PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14630694-0	2004	Etoposide induces chimeric Mll gene fusions.	Etoposide	0-9	lysine (K)-specific methyltransferase 2A	Mus musculus	27-30	
14630694-1	2004	MLL gene fusions are the hallmark of more than 70% of therapy-related leukemias (t-ML) associated with topoisomerase II inhibitors (e.g., etoposide) and cause leukemia in murine transgenic models.	Etoposide	138-147	lysine (K)-specific methyltransferase 2A	Mus musculus	0-3	
14630694-3	2004	We detected Mll fusions at a higher frequency following 100 microM etoposide for 8 h (16x10(-6) cell(-1)) than in no-drug controls (1.0x10(-6) cell(-1), P=0.0002) or after treatment with a comparably cytotoxic exposure to the antimicrotubule drug vincristine (1.0x10(-6) cell(-1), P=0.0047).	Etoposide	67-76	lysine (K)-specific methyltransferase 2A	Mus musculus	12-15	
14630694-7	2004	These findings indicate that etoposide triggers the formation of Mll gene fusions, a critical step for the development of treatment-induced leukemic transformation.	Etoposide	29-38	lysine (K)-specific methyltransferase 2A	Mus musculus	65-68	
26657054-5	2015	Etoposide-induced Kmt2a breakage was detected in fetal liver hematopoietic stem cells using a newly developed chromatin immunoprecipitation (ChIP) assay.	Etoposide	0-9	lysine (K)-specific methyltransferase 2A	Mus musculus	18-23	
16982737-1	2006	Etoposide-induced treatment-related acute myelogenous leukemia (t-AML) is characterized by rearrangements of the mixed lineage leukemia (MLL) gene with one of its >50 partner genes, most probably as a consequence of etoposide-induced DNA double-strand breaks (DSBs).	Etoposide	0-9	lysine (K)-specific methyltransferase 2A	Mus musculus	137-140	
16982737-1	2006	Etoposide-induced treatment-related acute myelogenous leukemia (t-AML) is characterized by rearrangements of the mixed lineage leukemia (MLL) gene with one of its >50 partner genes, most probably as a consequence of etoposide-induced DNA double-strand breaks (DSBs).	Etoposide	219-228	lysine (K)-specific methyltransferase 2A	Mus musculus	137-140	
16982737-2	2006	Recent studies have shown that etoposide-induced DSBs occur predominantly within the breakpoint cluster region (bcr) of the MLL gene.	Etoposide	31-40	lysine (K)-specific methyltransferase 2A	Mus musculus	124-127	
16982737-9	2006	Etoposide stimulated MLL fusion product formation in CAD cDNA-complemented MEFs but not in CAD KO MEFs.	Etoposide	0-9	lysine (K)-specific methyltransferase 2A	Mus musculus	21-24