PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34193614-7 2021 We then demonstrated that when the nuclear DNA of GSCs either in vitro or in GBM xenografts in mice was damaged by irradiation or treatment with etoposide, the DNA-PK complex dissociated from SOX2, which then interacted with WWP2, leading to SOX2 degradation and GSC differentiation. Etoposide 145-154 WW domain containing E3 ubiquitin protein ligase 2 Mus musculus 225-229