PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18687701-4	2008	DNA damage by etoposide causes E2F1-dependent induction of E1AF expression at transcriptional level.	Etoposide	14-23	E2F transcription factor 1 L homeolog	Xenopus laevis	31-35	
19148830-6	2009	Induction of apoptosis by treating miR17-92 or E2F1 transduced T-ALL cells with etoposide led to reduced or enhanced cell viability, respectively.	Etoposide	80-89	E2F transcription factor 1 L homeolog	Xenopus laevis	47-51	
18687701-5	2008	Furthermore, disruption of E1AF expression by E1AF RNAi decreased E2F1-induced apoptosis in response to etoposide.	Etoposide	104-113	E2F transcription factor 1 L homeolog	Xenopus laevis	66-70	
9863003-0	1999	p53-independent increase in E2F-1 expression enhances the cytotoxic effects of etoposide and of adriamycin.	Etoposide	79-88	E2F transcription factor 1 L homeolog	Xenopus laevis	28-33	
11325040-3	2000	Enforced expression of E2F-1 in interleukin-3-dependent myeloid cells led to preferential sensitivity to the topoisomerase II inhibitor, etoposide, which was independent of p53 accumulation.	Etoposide	137-146	E2F transcription factor 1 L homeolog	Xenopus laevis	23-28	
11325040-4	2000	Pretreatment of the E2F-1-expressing cells with ICRF-193, a second topoisomerase II inhibitor that does not cause DNA damage, protected these cells against etoposide-induced apoptosis.	Etoposide	156-165	E2F transcription factor 1 L homeolog	Xenopus laevis	20-25	
9863003-5	1999	Rather, induction of E2F-1 in the tumor cells correlates with their sensitivity to adriamycin or to etoposide.	Etoposide	100-109	E2F transcription factor 1 L homeolog	Xenopus laevis	21-26	
9032231-5	1997	E2F-1 overexpression in the myeloid cells preferentially sensitized cells to apoptosis when they were treated with the topoisomerase II inhibitor etoposide.	Etoposide	146-155	E2F transcription factor 1 L homeolog	Xenopus laevis	0-5	
9032231-7	1997	Coexpression of Bcl-2 and E2F-1 in 32D.3 cells protected them from etoposide-mediated apoptosis.	Etoposide	67-76	E2F transcription factor 1 L homeolog	Xenopus laevis	26-31	
28498400-0	2017	TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer.	Etoposide	42-51	E2F transcription factor 1 L homeolog	Xenopus laevis	68-72	
28498400-5	2017	Using FCM and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay, we found that TRIM28 siRNA in combination with etoposide increased apoptosis in vitro and in vivo which was induced by E2F1 activity, since the expression of E2F1 and its target genes was significantly increased in the cotreatment group.	Etoposide	152-161	E2F transcription factor 1 L homeolog	Xenopus laevis	224-228	
28498400-5	2017	Using FCM and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay, we found that TRIM28 siRNA in combination with etoposide increased apoptosis in vitro and in vivo which was induced by E2F1 activity, since the expression of E2F1 and its target genes was significantly increased in the cotreatment group.	Etoposide	152-161	E2F transcription factor 1 L homeolog	Xenopus laevis	263-267	
28498400-6	2017	Cell proliferation and apoptosis were almost completely abolished in the PAa cells cotreated with TRIM28 siRNA and etoposide following knockdown of E2F1.	Etoposide	115-124	E2F transcription factor 1 L homeolog	Xenopus laevis	148-152