PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31875206-6	2019	Tdp1"s unique catalytic cycle, which is centered on the formation of Tdp1-DNA covalent reaction intermediate, allows for two principally different targeting strategies: (1) catalytic inhibition of Tdp1 catalysis to prevent Tdp1-mediated repair of DNA-adducts that enhances the effectivity of chemotherapeutics; and (2) poisoning of Tdp1 by stabilization of the Tdp1- DNA covalent reaction intermediate, which would increase the half-life of a potentially toxic DNA-adduct by preventing its resolution, analogous to topoisomerase targeted poisons such as topotecan or etoposide.	Etoposide	567-576	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4	
23605487-6	2010	The specific topoisomerase poisons camptothecin and etoposide caused comparable effects, underlining that TDP1 plays an important role in the repair of topoisomerase-mediated DNA damage.	Etoposide	52-61	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	106-110	
26421495-4	2015	We found that TDP1kd cells are hypersensitive to etoposide (ETO).	Etoposide	49-58	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	14-18	
26421495-4	2015	We found that TDP1kd cells are hypersensitive to etoposide (ETO).	Etoposide	60-63	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	14-18	
26421495-5	2015	Moreover, we established in a chromatin context that following treatment with ETO, TDP1kd cells accumulate increased amounts of Top2alpha cleavage complexes, removing them with an altered kinetics.	Etoposide	78-81	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	83-87	
26421495-6	2015	We also showed that TDP1 depleted cells accumulate increased gammaH2AX and pS296Chk1 signals following treatment with ETO.	Etoposide	118-121	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	20-24	
26421495-10	2015	Finally, micronucleus analyses following ETO treatment revealed a higher frequency of micronucleus containing gammaH2AX signals on TDP1kd cells.	Etoposide	41-44	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	131-135	
21843105-5	2011	Tdp1 inhibitors should synergize not only with Top1-targeting drugs (camptothecins, indenoisoquinolines), but also with bleomycin, topoisomerase II (Top2) inhibitors (etoposide, doxorubicin) and DNA alkylating agents.	Etoposide	167-176	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4