PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23457546-7 2013 One of the genes that were induced by both EVI1 and etoposide was CDKN1A/p21/WAF, which in addition to its function as a cell cycle regulator plays an important role in conferring chemotherapy resistance in various tumor types. Etoposide 52-61 cyclin dependent kinase inhibitor 1A Homo sapiens 66-72 23457546-7 2013 One of the genes that were induced by both EVI1 and etoposide was CDKN1A/p21/WAF, which in addition to its function as a cell cycle regulator plays an important role in conferring chemotherapy resistance in various tumor types. Etoposide 52-61 cyclin dependent kinase inhibitor 1A Homo sapiens 73-76 23272236-4 2012 Etoposide-treated cells exhibited a senescent phenotype characterized by senile morphology, positive staining for senescence-associated beta-galactosidase, growth arrest and induction of p53 and p21(WAF1/CIP1). Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 195-198 23272236-4 2012 Etoposide-treated cells exhibited a senescent phenotype characterized by senile morphology, positive staining for senescence-associated beta-galactosidase, growth arrest and induction of p53 and p21(WAF1/CIP1). Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 199-208 20226587-3 2010 Co-treatment of etoposide and KG-135 markedly elevated the expression and phosphorylation at the serine 15 residue of p53 as well as the cellular levels of Bax and p21(Waf1/Cip1). Etoposide 16-25 cyclin dependent kinase inhibitor 1A Homo sapiens 164-167 21903579-4 2011 A focused real-time quantitative reverse transcription PCR array of known p53-regulated genes identified p21(WAF1) (CDKN1A) as the highest ranked gene to be differentially expressed between B-cell precursor (BCP)-ALL and T-ALL xenografts following exposure to the DNA-damaging drug etoposide. Etoposide 282-291 cyclin dependent kinase inhibitor 1A Homo sapiens 105-108 21903579-4 2011 A focused real-time quantitative reverse transcription PCR array of known p53-regulated genes identified p21(WAF1) (CDKN1A) as the highest ranked gene to be differentially expressed between B-cell precursor (BCP)-ALL and T-ALL xenografts following exposure to the DNA-damaging drug etoposide. Etoposide 282-291 cyclin dependent kinase inhibitor 1A Homo sapiens 109-113 21903579-4 2011 A focused real-time quantitative reverse transcription PCR array of known p53-regulated genes identified p21(WAF1) (CDKN1A) as the highest ranked gene to be differentially expressed between B-cell precursor (BCP)-ALL and T-ALL xenografts following exposure to the DNA-damaging drug etoposide. Etoposide 282-291 cyclin dependent kinase inhibitor 1A Homo sapiens 116-122 21168391-10 2011 These changes were not observed with other p53 activators, like etoposide and nutlin-3a that increased the p21 protein level. Etoposide 64-73 cyclin dependent kinase inhibitor 1A Homo sapiens 107-110 20226587-3 2010 Co-treatment of etoposide and KG-135 markedly elevated the expression and phosphorylation at the serine 15 residue of p53 as well as the cellular levels of Bax and p21(Waf1/Cip1). Etoposide 16-25 cyclin dependent kinase inhibitor 1A Homo sapiens 168-172 20226587-3 2010 Co-treatment of etoposide and KG-135 markedly elevated the expression and phosphorylation at the serine 15 residue of p53 as well as the cellular levels of Bax and p21(Waf1/Cip1). Etoposide 16-25 cyclin dependent kinase inhibitor 1A Homo sapiens 173-177 20226587-6 2010 Our results indicate that etoposide-induced apoptosis in HeLa cells can be potentiated in the presence of KG-135 through a mechanism that involves the stabilization of p53 and the stimulation of Bax- and p21-mediated apoptotic signaling pathways. Etoposide 26-35 cyclin dependent kinase inhibitor 1A Homo sapiens 204-207 19421231-7 2009 p21(WAF1) which is overexpressed in the latter, is involved in this protective effect, as siRNA-mediated inhibition of p21(WAF1) restores sensitivity to etoposide. Etoposide 153-162 cyclin dependent kinase inhibitor 1A Homo sapiens 0-8 19421231-7 2009 p21(WAF1) which is overexpressed in the latter, is involved in this protective effect, as siRNA-mediated inhibition of p21(WAF1) restores sensitivity to etoposide. Etoposide 153-162 cyclin dependent kinase inhibitor 1A Homo sapiens 119-127 17534580-11 2007 CONCLUSION: Our study demonstrates that VPA sensitizes U87, U251, and LN18 cells to the cytotoxic effects of etoposide in vitro by inducing differentiation and up-regulating the expression of p21/WAF1 and both isoforms of topoisomerase-II. Etoposide 109-118 cyclin dependent kinase inhibitor 1A Homo sapiens 192-195 17534580-11 2007 CONCLUSION: Our study demonstrates that VPA sensitizes U87, U251, and LN18 cells to the cytotoxic effects of etoposide in vitro by inducing differentiation and up-regulating the expression of p21/WAF1 and both isoforms of topoisomerase-II. Etoposide 109-118 cyclin dependent kinase inhibitor 1A Homo sapiens 196-200 17252195-3 2007 Etoposide-induced apoptotic cell death is efficiently prevented in cells that overexpress a dominant negative mutant of Cdk2 (Cdk2-dn) or p21(WAF1/CIP1), a specific Cdk inhibitor. Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 138-141 17252195-3 2007 Etoposide-induced apoptotic cell death is efficiently prevented in cells that overexpress a dominant negative mutant of Cdk2 (Cdk2-dn) or p21(WAF1/CIP1), a specific Cdk inhibitor. Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 142-146 17252195-3 2007 Etoposide-induced apoptotic cell death is efficiently prevented in cells that overexpress a dominant negative mutant of Cdk2 (Cdk2-dn) or p21(WAF1/CIP1), a specific Cdk inhibitor. Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 147-151 17252195-5 2007 Disruption of the mitochondrial transmembrane potential in etoposide-induced cells is prevented in cells that overexpress Cdk2-dn or p21(WAF1/CIP1), while this transition is prominently promoted in Cyclin A-expressing cells. Etoposide 59-68 cyclin dependent kinase inhibitor 1A Homo sapiens 133-136 17252195-5 2007 Disruption of the mitochondrial transmembrane potential in etoposide-induced cells is prevented in cells that overexpress Cdk2-dn or p21(WAF1/CIP1), while this transition is prominently promoted in Cyclin A-expressing cells. Etoposide 59-68 cyclin dependent kinase inhibitor 1A Homo sapiens 137-141 17252195-5 2007 Disruption of the mitochondrial transmembrane potential in etoposide-induced cells is prevented in cells that overexpress Cdk2-dn or p21(WAF1/CIP1), while this transition is prominently promoted in Cyclin A-expressing cells. Etoposide 59-68 cyclin dependent kinase inhibitor 1A Homo sapiens 142-146 16513841-6 2006 Subsequent stimulation of these cells with an anticancer agent, etoposide, results in augmented NF-kappaB-dependent p21(waf1/cip1) induction and increased chemoresistance of the leukemia cells. Etoposide 64-73 cyclin dependent kinase inhibitor 1A Homo sapiens 116-129 14660614-7 2004 These data suggest that during etoposide-induced apoptosis, 31-kDa promotes caspase-mediated cell death by inhibiting E2A-mediated activation of p21(Waf1/Cip1) transcription. Etoposide 31-40 cyclin dependent kinase inhibitor 1A Homo sapiens 145-148 16093994-0 2005 Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. Etoposide 54-63 cyclin dependent kinase inhibitor 1A Homo sapiens 27-41 16093994-0 2005 Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. Etoposide 65-74 cyclin dependent kinase inhibitor 1A Homo sapiens 27-41 15191662-11 2004 CONCLUSION: These observations suggest that p33(ING1b) up-regulates p53 protein, and cooperate with p53 in stimulating expression of p21(WAF1) and Bax gene, thus to enhance etoposide-induced apoptosis via p53-dependent pathways. Etoposide 173-182 cyclin dependent kinase inhibitor 1A Homo sapiens 133-136 15191662-11 2004 CONCLUSION: These observations suggest that p33(ING1b) up-regulates p53 protein, and cooperate with p53 in stimulating expression of p21(WAF1) and Bax gene, thus to enhance etoposide-induced apoptosis via p53-dependent pathways. Etoposide 173-182 cyclin dependent kinase inhibitor 1A Homo sapiens 137-141 14660614-7 2004 These data suggest that during etoposide-induced apoptosis, 31-kDa promotes caspase-mediated cell death by inhibiting E2A-mediated activation of p21(Waf1/Cip1) transcription. Etoposide 31-40 cyclin dependent kinase inhibitor 1A Homo sapiens 149-153 14660614-7 2004 These data suggest that during etoposide-induced apoptosis, 31-kDa promotes caspase-mediated cell death by inhibiting E2A-mediated activation of p21(Waf1/Cip1) transcription. Etoposide 31-40 cyclin dependent kinase inhibitor 1A Homo sapiens 154-158 12767922-5 2003 Wortmannin, an ATM- and DNA-dependent protein kinase inhibitor, partially inhibited p21(WAF1/Cip1) expression induced by genistein and etoposide, whereas UCN-01, a Chk1 inhibitor, partially blocked etoposide, but not genistein-induced p21(WAF1/Cip1) expression. Etoposide 135-144 cyclin dependent kinase inhibitor 1A Homo sapiens 84-87 12767922-0 2003 P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells. Etoposide 52-61 cyclin dependent kinase inhibitor 1A Homo sapiens 0-3 12767922-2 2003 Here we show that topoisomerase II inhibitors, genistein and etoposide, induce p21(WAF1/Cip1) expression mainly in a p53-dependent manner in human lung cancer cell line A549. Etoposide 61-70 cyclin dependent kinase inhibitor 1A Homo sapiens 79-82 12767922-2 2003 Here we show that topoisomerase II inhibitors, genistein and etoposide, induce p21(WAF1/Cip1) expression mainly in a p53-dependent manner in human lung cancer cell line A549. Etoposide 61-70 cyclin dependent kinase inhibitor 1A Homo sapiens 83-87 12767922-2 2003 Here we show that topoisomerase II inhibitors, genistein and etoposide, induce p21(WAF1/Cip1) expression mainly in a p53-dependent manner in human lung cancer cell line A549. Etoposide 61-70 cyclin dependent kinase inhibitor 1A Homo sapiens 88-92 12767922-5 2003 Wortmannin, an ATM- and DNA-dependent protein kinase inhibitor, partially inhibited p21(WAF1/Cip1) expression induced by genistein and etoposide, whereas UCN-01, a Chk1 inhibitor, partially blocked etoposide, but not genistein-induced p21(WAF1/Cip1) expression. Etoposide 135-144 cyclin dependent kinase inhibitor 1A Homo sapiens 88-92 12767922-5 2003 Wortmannin, an ATM- and DNA-dependent protein kinase inhibitor, partially inhibited p21(WAF1/Cip1) expression induced by genistein and etoposide, whereas UCN-01, a Chk1 inhibitor, partially blocked etoposide, but not genistein-induced p21(WAF1/Cip1) expression. Etoposide 135-144 cyclin dependent kinase inhibitor 1A Homo sapiens 93-97 12767922-6 2003 These data suggest that both genistein and etoposide induce p21(WAF1/Cip1) expression in a p53-dependent manner. Etoposide 43-52 cyclin dependent kinase inhibitor 1A Homo sapiens 60-63 12767922-6 2003 These data suggest that both genistein and etoposide induce p21(WAF1/Cip1) expression in a p53-dependent manner. Etoposide 43-52 cyclin dependent kinase inhibitor 1A Homo sapiens 64-68 12767922-6 2003 These data suggest that both genistein and etoposide induce p21(WAF1/Cip1) expression in a p53-dependent manner. Etoposide 43-52 cyclin dependent kinase inhibitor 1A Homo sapiens 69-73 12767922-8 2003 Our results suggest different mechanisms participate in genistein and etoposide induced p21(WAF1/Cip1) expression. Etoposide 70-79 cyclin dependent kinase inhibitor 1A Homo sapiens 88-91 12767922-8 2003 Our results suggest different mechanisms participate in genistein and etoposide induced p21(WAF1/Cip1) expression. Etoposide 70-79 cyclin dependent kinase inhibitor 1A Homo sapiens 92-96 12767922-8 2003 Our results suggest different mechanisms participate in genistein and etoposide induced p21(WAF1/Cip1) expression. Etoposide 70-79 cyclin dependent kinase inhibitor 1A Homo sapiens 97-101 12513833-1 2002 The objective of this study was to explore the effect of p21(WAF1) on the sensitivity to chemotherapeutic agent VP-16, etoposide, in leukemia cell line K562. Etoposide 119-128 cyclin dependent kinase inhibitor 1A Homo sapiens 57-60 15314975-0 2003 Expression of p21 and bcl-2 proteins in paraffin-embedded preparations of non-small cell lung cancer in stage IIIA after Etoposide and Cisplatin induced chemotherapy. Etoposide 121-130 cyclin dependent kinase inhibitor 1A Homo sapiens 14-17 11821415-7 2002 Inhibition of ERK activation by PD98059 or U0126 attenuated p21(CIP1) induction, resulting in partial release of the G(2)/M cell cycle arrest induced by ETOP. Etoposide 153-157 cyclin dependent kinase inhibitor 1A Homo sapiens 64-68 12553001-0 2002 DNA topoisomerase II inhibitor, etoposide, induces p21WAF1/CIP1 through down-regulation of c-Myc in K562 cells. Etoposide 32-41 cyclin dependent kinase inhibitor 1A Homo sapiens 51-63 12553001-2 2002 To investigate the mechanism by which etoposide acts as an anticancer agent, the relationship between p21WAF1/CIP1 (p21) and c-Myc was studied. Etoposide 38-47 cyclin dependent kinase inhibitor 1A Homo sapiens 102-114 12553001-2 2002 To investigate the mechanism by which etoposide acts as an anticancer agent, the relationship between p21WAF1/CIP1 (p21) and c-Myc was studied. Etoposide 38-47 cyclin dependent kinase inhibitor 1A Homo sapiens 102-105 12553001-9 2002 Etoposide activated the p21 promoter in a concentration-dependent manner, and etoposide-induced luciferase activity was suppressed by co-transfection of c-Myc. Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 24-27 12513833-1 2002 The objective of this study was to explore the effect of p21(WAF1) on the sensitivity to chemotherapeutic agent VP-16, etoposide, in leukemia cell line K562. Etoposide 119-128 cyclin dependent kinase inhibitor 1A Homo sapiens 61-65 11423989-6 2001 Adriamycin, etoposide, cisplatinum, colcemid and resveratrol induce distinct cellular responses; however, absence of p21 favors apoptosis-induction by adriamycin, etoposide and colcemid. Etoposide 163-172 cyclin dependent kinase inhibitor 1A Homo sapiens 117-120 12429914-5 2002 BL also inhibited the p53-dependent increase of p21 protein expression in cells exposed to the DNA damag-ing agent etoposide, and favored a greater G2/M arrest as compared to the non-BL exposed cells. Etoposide 115-124 cyclin dependent kinase inhibitor 1A Homo sapiens 48-51 9687575-8 1998 Importantly, we could show that MT1 cells are not deficient in the p53-dependent apoptosis pathway; treatment with etoposide, a topoisomerase II inhibitor, resulted in p53 and p21/waf-1 protein expression and apoptosis in both cell lines. Etoposide 115-124 cyclin dependent kinase inhibitor 1A Homo sapiens 176-185 11045764-12 2000 Clonogenic assays showed that Ad5CMV-p21 reduced the sensitivity of MDA-MB-231 to VP-16 and paclitaxel. Etoposide 82-87 cyclin dependent kinase inhibitor 1A Homo sapiens 37-40 11005251-5 2000 In etoposide model with chip hybridization, we defined signaling pathways that mediate apoptosis in p53 dependent manner (through activation of p53 target genes such as Waf-1/p21, PCNA, GPX, S100A2 and PTGF-beta) as well as in p53-independent manner (through activation of ODC and TGF-beta receptor, among others). Etoposide 3-12 cyclin dependent kinase inhibitor 1A Homo sapiens 169-174 11005251-5 2000 In etoposide model with chip hybridization, we defined signaling pathways that mediate apoptosis in p53 dependent manner (through activation of p53 target genes such as Waf-1/p21, PCNA, GPX, S100A2 and PTGF-beta) as well as in p53-independent manner (through activation of ODC and TGF-beta receptor, among others). Etoposide 3-12 cyclin dependent kinase inhibitor 1A Homo sapiens 175-178 10218124-6 1999 In contrast, HGF enhanced basal and etoposide-induced p21WAF1/CIP1 protein levels in 9/11 and 7/11 of the cases, respectively. Etoposide 36-45 cyclin dependent kinase inhibitor 1A Homo sapiens 62-66 11062729-7 2000 Among the cell cycle controlling genes, c-Myc and P21Cip1/WAF1 showed impressive responses to the two etoposide concentrations. Etoposide 102-111 cyclin dependent kinase inhibitor 1A Homo sapiens 50-57 11062729-7 2000 Among the cell cycle controlling genes, c-Myc and P21Cip1/WAF1 showed impressive responses to the two etoposide concentrations. Etoposide 102-111 cyclin dependent kinase inhibitor 1A Homo sapiens 58-62 11062729-11 2000 Differing responses of c-Myc and p21Cip1/WAF1 at two concentrations may govern the antiproliferative effects of etoposide. Etoposide 112-121 cyclin dependent kinase inhibitor 1A Homo sapiens 33-40 11062729-11 2000 Differing responses of c-Myc and p21Cip1/WAF1 at two concentrations may govern the antiproliferative effects of etoposide. Etoposide 112-121 cyclin dependent kinase inhibitor 1A Homo sapiens 41-45 10023685-0 1999 Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. Etoposide 54-63 cyclin dependent kinase inhibitor 1A Homo sapiens 27-41 10023685-0 1999 Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. Etoposide 65-74 cyclin dependent kinase inhibitor 1A Homo sapiens 27-41 9739169-2 1998 Etoposide treatment increased expression of the p21 gene, a cyclin kinase inhibitor, at both the mRNA and protein levels. Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 48-51 9739169-4 1998 A substrate for cyclin kinase, pRB, was unphosphorylated by etoposide treatment, but remained unaffected by deferoxamine, indicating that p21 was functional after etoposide, but not after deferoxamine treatment. Etoposide 163-172 cyclin dependent kinase inhibitor 1A Homo sapiens 138-141 9739169-7 1998 After etoposide treatment, the level of ubiquitinated p21 was diminished and a high level of unubiquitinated p21 expression was observed. Etoposide 6-15 cyclin dependent kinase inhibitor 1A Homo sapiens 54-57 9739169-7 1998 After etoposide treatment, the level of ubiquitinated p21 was diminished and a high level of unubiquitinated p21 expression was observed. Etoposide 6-15 cyclin dependent kinase inhibitor 1A Homo sapiens 109-112 14646555-4 1997 p53 and p21/waf1 protein levels were elevated in etoposide-treated cells, but not in cells subjected to serum with-drawal. Etoposide 49-58 cyclin dependent kinase inhibitor 1A Homo sapiens 8-11 14646555-4 1997 p53 and p21/waf1 protein levels were elevated in etoposide-treated cells, but not in cells subjected to serum with-drawal. Etoposide 49-58 cyclin dependent kinase inhibitor 1A Homo sapiens 12-16 7970699-4 1994 The DNA damaging agent etoposide induced p53 accumulation only in cells harboring wild-type p53 yet it induced WAF1/Cip1 gene expression in cells carrying wild-type or mutant p53, suggesting the involvement of p53-dependent and independent signaling pathways in the regulation of WAF1/Cip1 gene expression. Etoposide 23-32 cyclin dependent kinase inhibitor 1A Homo sapiens 111-115 9054953-8 1997 Etoposide-induced apoptosis, and its potentiation by staurosporine, were associated with reduced c-myc expression, and a moderate increase in p21WAF1/CIP1 mRNA and protein levels. Etoposide 0-9 cyclin dependent kinase inhibitor 1A Homo sapiens 150-154 8620501-8 1996 First, they have functional p53: the product of the p53-dependent gene waf-1 was increased after etoposide treatment. Etoposide 97-106 cyclin dependent kinase inhibitor 1A Homo sapiens 71-76 7970699-4 1994 The DNA damaging agent etoposide induced p53 accumulation only in cells harboring wild-type p53 yet it induced WAF1/Cip1 gene expression in cells carrying wild-type or mutant p53, suggesting the involvement of p53-dependent and independent signaling pathways in the regulation of WAF1/Cip1 gene expression. Etoposide 23-32 cyclin dependent kinase inhibitor 1A Homo sapiens 116-120 7970699-4 1994 The DNA damaging agent etoposide induced p53 accumulation only in cells harboring wild-type p53 yet it induced WAF1/Cip1 gene expression in cells carrying wild-type or mutant p53, suggesting the involvement of p53-dependent and independent signaling pathways in the regulation of WAF1/Cip1 gene expression. Etoposide 23-32 cyclin dependent kinase inhibitor 1A Homo sapiens 280-284 7970699-4 1994 The DNA damaging agent etoposide induced p53 accumulation only in cells harboring wild-type p53 yet it induced WAF1/Cip1 gene expression in cells carrying wild-type or mutant p53, suggesting the involvement of p53-dependent and independent signaling pathways in the regulation of WAF1/Cip1 gene expression. Etoposide 23-32 cyclin dependent kinase inhibitor 1A Homo sapiens 285-289 26102294-3 2015 Previously, we showed that following etoposide (ETO) treatment embryonal carcinoma PA-1 cells undergo a p53-dependent upregulation of OCT4A and p21Cip1 (governing self-renewal and regulating cell cycle inhibition and senescence, respectively). Etoposide 37-46 cyclin dependent kinase inhibitor 1A Homo sapiens 144-151 26625199-4 2016 In HCT116 p53+/+ cells treated with the DNA-damaging agent, etoposide, HBZ reduced p53-mediated activation of p21/CDKN1A and GADD45A expression, which was associated with a delay in G2 phase-arrest. Etoposide 60-69 cyclin dependent kinase inhibitor 1A Homo sapiens 110-113 26625199-4 2016 In HCT116 p53+/+ cells treated with the DNA-damaging agent, etoposide, HBZ reduced p53-mediated activation of p21/CDKN1A and GADD45A expression, which was associated with a delay in G2 phase-arrest. Etoposide 60-69 cyclin dependent kinase inhibitor 1A Homo sapiens 114-120 29372665-2 2018 Chemoresistant ESC-like embryonal carcinoma PA1 cells treated with etoposide (ETO) were previously found to undergo prolonged G2 arrest with transient p53-dependent upregulation of opposing fate regulators, p21CIP1 (senescence) and OCT4A (self-renewal). Etoposide 67-76 cyclin dependent kinase inhibitor 1A Homo sapiens 207-214 29372665-2 2018 Chemoresistant ESC-like embryonal carcinoma PA1 cells treated with etoposide (ETO) were previously found to undergo prolonged G2 arrest with transient p53-dependent upregulation of opposing fate regulators, p21CIP1 (senescence) and OCT4A (self-renewal). Etoposide 78-81 cyclin dependent kinase inhibitor 1A Homo sapiens 207-214 26506264-5 2015 Transient siRNA suppression of p21(WAF1) in the BCP-ALL 697 cell line resulted in a moderate depletion of the cell fraction in G1 phase and marked increase in PS externalization following exposure to etoposide. Etoposide 200-209 cyclin dependent kinase inhibitor 1A Homo sapiens 31-34 26506264-5 2015 Transient siRNA suppression of p21(WAF1) in the BCP-ALL 697 cell line resulted in a moderate depletion of the cell fraction in G1 phase and marked increase in PS externalization following exposure to etoposide. Etoposide 200-209 cyclin dependent kinase inhibitor 1A Homo sapiens 35-39 26506264-6 2015 Furthermore, stable lentiviral p21(WAF1) silencing in the BCP-ALL Nalm-6 cell line accelerated PS externalization and cell death following exposure to etoposide and vorinostat, supporting previous findings. Etoposide 151-160 cyclin dependent kinase inhibitor 1A Homo sapiens 31-34 26506264-6 2015 Furthermore, stable lentiviral p21(WAF1) silencing in the BCP-ALL Nalm-6 cell line accelerated PS externalization and cell death following exposure to etoposide and vorinostat, supporting previous findings. Etoposide 151-160 cyclin dependent kinase inhibitor 1A Homo sapiens 35-39 26102294-3 2015 Previously, we showed that following etoposide (ETO) treatment embryonal carcinoma PA-1 cells undergo a p53-dependent upregulation of OCT4A and p21Cip1 (governing self-renewal and regulating cell cycle inhibition and senescence, respectively). Etoposide 48-51 cyclin dependent kinase inhibitor 1A Homo sapiens 144-151 26102294-5 2015 PA-1 cells treated with ETO display highly heterogeneous increases in OCT4A and p21Cip1 indicative of dis-adaptation catastrophe. Etoposide 24-27 cyclin dependent kinase inhibitor 1A Homo sapiens 80-87 23287532-4 2013 Nuclear POU5F1/OCT4A and P21CIP1 were upregulated in the same cells following etoposide-induced G 2M arrest. Etoposide 78-87 cyclin dependent kinase inhibitor 1A Homo sapiens 25-32