PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17047058-3	2006	Ad-hTERT-CD conferred sensitivity to 5-fluorocytosine (5-FC) in bladder cancer cells, which could be enhanced by etoposide treatment, but not in normal cells.	Etoposide	113-122	telomerase reverse transcriptase	Homo sapiens	3-8	
17047058-5	2006	By contrast, etoposide activated p53 and down-regulated hTERT promoter activity in normal cells.	Etoposide	13-22	telomerase reverse transcriptase	Homo sapiens	56-61	
17047058-7	2006	Combination index analysis revealed that combined therapy of Ad-hTERT-CD (10(9) plaque-forming units)/5-FC (200 mg/kg) with etoposide (2 mg/kg) synergistically suppressed tumor growth and prolonged survival in mice bearing syngeneic MBT-2 bladder tumors.	Etoposide	124-133	telomerase reverse transcriptase	Homo sapiens	64-69	
17047058-9	2006	Furthermore, increased infiltrating CD4(+) and CD8(+) T cells and necrosis within tumors were found in mice receiving combination therapy of Ad-hTERT-CD and etoposide compared with those treated with either treatment alone.	Etoposide	157-166	telomerase reverse transcriptase	Homo sapiens	144-149	
15003732-6	2004	RESULTS: MCF-7 cells treated with taxol and etoposide were found positive for all hTERT splicing variants, while the expression of hTERT beta plus transcript did not differ significantly before and after exposure.	Etoposide	44-53	telomerase reverse transcriptase	Homo sapiens	82-87	
16613901-4	2006	Etoposide, but not methylmethanesulfate, also promotes mtDNA lesions in cells expressing active hTERT, indicating genotoxic specificity in this response.	Etoposide	0-9	telomerase reverse transcriptase	Homo sapiens	96-101	
15326479-4	2004	Here, we show that overexpression of the catalytic subunit of telomerase (hTERT) protects a maturation-resistant acute promyelocytic leukemia (APL) cell line from apoptosis induced by the tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand (TRAIL) and not from apoptosis induced by chemotherapeutic drugs such as etoposide or cisplatin.	Etoposide	330-339	telomerase reverse transcriptase	Homo sapiens	74-79	
16619047-3	2006	Within the same time frame, hTERT depletion facilitated the induction of apoptotic cell death by cisplatin, etoposide, mitomycin C and reactive oxygen species, yet failed to sensitize cells to death induction via the CD95 death receptor.	Etoposide	108-117	telomerase reverse transcriptase	Homo sapiens	28-33	
15003732-6	2004	RESULTS: MCF-7 cells treated with taxol and etoposide were found positive for all hTERT splicing variants, while the expression of hTERT beta plus transcript did not differ significantly before and after exposure.	Etoposide	44-53	telomerase reverse transcriptase	Homo sapiens	131-136	
12594176-4	2003	Here, we show that overexpression of wild-type human TERT in HeLa cells, and in a cells lacking TERT but containing the telomerase RNA template, increases their resistance to apoptosis induced by the DNA damaging agent etoposide or the bacterial alkaloid staurosporine.	Etoposide	219-228	telomerase reverse transcriptase	Homo sapiens	53-57	
12370759-9	2002	We also observed enhanced induction of apoptosis by chemotherapeutic reagents, including cisplatin, docetaxel and etoposide, in DN-hTERT-expressing A549 cells, as compared with WT-hTERT-expressing cells.	Etoposide	114-123	telomerase reverse transcriptase	Homo sapiens	131-136	
12370759-9	2002	We also observed enhanced induction of apoptosis by chemotherapeutic reagents, including cisplatin, docetaxel and etoposide, in DN-hTERT-expressing A549 cells, as compared with WT-hTERT-expressing cells.	Etoposide	114-123	telomerase reverse transcriptase	Homo sapiens	180-185	
11867204-7	2002	Importantly, we found that hTERT-transfected K562 cells are protected against apoptosis induced by serum deprivation and double-stranded DNA break inducing agents (ionizing irradiation, and etoposide (VP-16)), but not against DNA synthesis inhibitors (1-beta-D-arabinofuranosylcytosine and hydroxyurea).	Etoposide	190-199	telomerase reverse transcriptase	Homo sapiens	27-32	
11867204-7	2002	Importantly, we found that hTERT-transfected K562 cells are protected against apoptosis induced by serum deprivation and double-stranded DNA break inducing agents (ionizing irradiation, and etoposide (VP-16)), but not against DNA synthesis inhibitors (1-beta-D-arabinofuranosylcytosine and hydroxyurea).	Etoposide	201-206	telomerase reverse transcriptase	Homo sapiens	27-32	
23178572-4	2013	Conversely, knock-down of endogenous HIC1 in BJ-Tert through RNA interference up-regulates p21 in basal conditions and further potentiates this CKI in response to apoptotic etoposide-induced DNA damage.	Etoposide	173-182	telomerase reverse transcriptase	Homo sapiens	48-52	
22728163-5	2012	The treatment of normal human T lymphocytes and fibroblasts with chemotherapeutic agents doxorubicin (DOX) or etoposide (VP16) led to significant shortening of telomeres, down-regulation of telomerase activity, and diminished expression of telomerase reverse transcriptase (hTERT) and the telomere binding proteins TPP1 and POT1.	Etoposide	110-119	telomerase reverse transcriptase	Homo sapiens	240-272	
22728163-5	2012	The treatment of normal human T lymphocytes and fibroblasts with chemotherapeutic agents doxorubicin (DOX) or etoposide (VP16) led to significant shortening of telomeres, down-regulation of telomerase activity, and diminished expression of telomerase reverse transcriptase (hTERT) and the telomere binding proteins TPP1 and POT1.	Etoposide	110-119	telomerase reverse transcriptase	Homo sapiens	274-279