PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21867601-1	2011	This study was aimed to investigate the expression of Na(+)/H(+) exchanger 1 (NHE1) in K562 and HL-60 cells undergoing DNA damage induced by etoposide and to elucidate the regulating mechanism.	Etoposide	141-150	solute carrier family 9 member A1	Homo sapiens	54-76	
21867601-1	2011	This study was aimed to investigate the expression of Na(+)/H(+) exchanger 1 (NHE1) in K562 and HL-60 cells undergoing DNA damage induced by etoposide and to elucidate the regulating mechanism.	Etoposide	141-150	solute carrier family 9 member A1	Homo sapiens	78-82	
21867601-2	2011	Real-time quantitative PCR (RQ-PCR) and Western blot methods were used to determine the expression of NHE1 in K562 cells after the treating with etoposide.	Etoposide	145-154	solute carrier family 9 member A1	Homo sapiens	102-106	
21867601-4	2011	The luciferase reporter vector containing NHE1 promoter was constructed to measure relative luciferase activity after treating with different etoposide concentrations.	Etoposide	142-151	solute carrier family 9 member A1	Homo sapiens	42-46	
21867601-5	2011	The results showed that the mRNA and protein of NHE1 increased in accordance with apoptosis ratio in HL-60 cells after treated with etoposide (p < 0.05), but no such obvious increase in K562 cells.	Etoposide	132-141	solute carrier family 9 member A1	Homo sapiens	48-52	
21867601-6	2011	Treatment with NHE1 specific inhibitor could block etoposide induced alkalization and reduce the apoptosis ratio of HL-60 cells.	Etoposide	51-60	solute carrier family 9 member A1	Homo sapiens	15-19	
21867601-8	2011	Relative luciferase activity of reporter vector containing NHE1 promoter however increased in K562 cells after treated with etoposide.	Etoposide	124-133	solute carrier family 9 member A1	Homo sapiens	59-63	
21867601-9	2011	It is concluded that the expression of NHE1 is up-regulated in the process of apoptosis of HL-60 cells induced by etoposide and depends on the pHi increasing caused by NHE1 up-regulation which is not found in K562 cells although the transcriptional activity increased.	Etoposide	114-123	solute carrier family 9 member A1	Homo sapiens	39-43	
20561412-0	2010	[Role of Na(+)/H(+) exchanger 1 in apoptosis of HL-60 cells induced by etoposide and its mechanism].	Etoposide	71-80	solute carrier family 9 member A1	Homo sapiens	9-31	
20561412-1	2010	This study was aimed to investigate the role of Na(+)/H(+) exchanger 1 (NHE1) in apoptosis of HL-60 cells induced by etoposide.	Etoposide	117-126	solute carrier family 9 member A1	Homo sapiens	48-70	
20561412-1	2010	This study was aimed to investigate the role of Na(+)/H(+) exchanger 1 (NHE1) in apoptosis of HL-60 cells induced by etoposide.	Etoposide	117-126	solute carrier family 9 member A1	Homo sapiens	72-76	
20561412-2	2010	Real-time quantitative PCR (RQ-PCR) and Western blot methods were used to determine the expression of NHE1 in HL-60 cells after the treatment with etoposide.	Etoposide	147-156	solute carrier family 9 member A1	Homo sapiens	102-106	
20561412-6	2010	The expression level of NHE1 mRNA increased by 2.848 +/- 0.886 times after treatment with etoposide for 12 hours (p < 0.01), and the expression of NHE1 protein was also up-regulated (p < 0.01).	Etoposide	90-99	solute carrier family 9 member A1	Homo sapiens	24-28	
20561412-6	2010	The expression level of NHE1 mRNA increased by 2.848 +/- 0.886 times after treatment with etoposide for 12 hours (p < 0.01), and the expression of NHE1 protein was also up-regulated (p < 0.01).	Etoposide	90-99	solute carrier family 9 member A1	Homo sapiens	150-154	
20561412-9	2010	It is concluded that the expression of NHE1 is up-regulated in process of apoptosis of HL-60 cells induced by etoposide and the apoptosis depends on the pH increase caused by NHE1 higher expression.	Etoposide	110-119	solute carrier family 9 member A1	Homo sapiens	39-43