PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11741320-0 2001 Etoposide and adriamycin but not genistein can activate the checkpoint kinase Chk2 independently of ATM/ATR. Etoposide 0-9 checkpoint kinase 2 Homo sapiens 78-82 12717439-2 2003 We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. Etoposide 105-114 checkpoint kinase 2 Homo sapiens 15-34 12717439-2 2003 We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. Etoposide 105-114 checkpoint kinase 2 Homo sapiens 36-40 12717439-5 2003 Moreover, E2F-1 is resistant to induction by etoposide in tumour cells expressing mutant chk2. Etoposide 45-54 checkpoint kinase 2 Homo sapiens 89-93 11741320-1 2001 We have investigated the effects of three unrelated topoisomerase 2 inhibitors, genistein, adriamycin, and etoposide, on phosphorylation/activation of the checkpoint kinase Chk2 in normal or ATM-deficient (ATM-) human fibroblasts and in cells overexpressing a catalytically inactive ATR kinase. Etoposide 107-116 checkpoint kinase 2 Homo sapiens 173-177 11741320-2 2001 We demonstrate that genistein activates Chk2 in a strictly ATM-dependent manner, whereas etoposide and adriamycin can trigger Chk2 activation in long-term cultures of ATM- cells. Etoposide 89-98 checkpoint kinase 2 Homo sapiens 126-130 34960710-5 2021 We determined that treatment of HBc-expressing hepatocytes with genotoxic agents, e.g., etoposide or hydrogen peroxide, activated the host ATM-Chk2 pathway, as determined by increased phosphorylation of ATM at Ser1981 and Chk2 at Thr68. Etoposide 88-97 checkpoint kinase 2 Homo sapiens 143-147 11096068-7 2001 In contrast, the topoisomerase II inhibitor etoposide induced phosphorylation of p53 and Chk2 in ATM-positive and ATM-deficient cells. Etoposide 44-53 checkpoint kinase 2 Homo sapiens 89-93 34960710-5 2021 We determined that treatment of HBc-expressing hepatocytes with genotoxic agents, e.g., etoposide or hydrogen peroxide, activated the host ATM-Chk2 pathway, as determined by increased phosphorylation of ATM at Ser1981 and Chk2 at Thr68. Etoposide 88-97 checkpoint kinase 2 Homo sapiens 222-226 24915421-9 2014 WJ35435 was less effective than camptothecin and etoposide in inducing the phosphorylation and activation of Chk1, Chk2 and RPA32 which were crucial coordinators in DNA repair pathway, indicating a low DNA repair activity to WJ35435 action. Etoposide 49-58 checkpoint kinase 2 Homo sapiens 115-119 30516086-8 2018 Etoposide-induced DNA damage affected the phosphorylation of gamma-H2AX, CHK1 and CHK2 without affecting cell viability. Etoposide 0-9 checkpoint kinase 2 Homo sapiens 82-86 25088203-7 2015 Furthermore, the phosphorylation of ATM targets, including gammaH2AX, threonine 68 (T68) on CHK2 (CHK2 pT68) and serine 15 (S15) on p53 were decreased in overexpression and increased in knockdown BMI1 cells in response to ETOP. Etoposide 222-226 checkpoint kinase 2 Homo sapiens 92-96 25088203-7 2015 Furthermore, the phosphorylation of ATM targets, including gammaH2AX, threonine 68 (T68) on CHK2 (CHK2 pT68) and serine 15 (S15) on p53 were decreased in overexpression and increased in knockdown BMI1 cells in response to ETOP. Etoposide 222-226 checkpoint kinase 2 Homo sapiens 98-102 25088203-11 2015 Stable expression of these BMI1 mutants decreased ETOP-induced ATM pS1981 and CHK2 pT68, but not ETOP-elicited gammaH2AX in MCF7 cells. Etoposide 50-54 checkpoint kinase 2 Homo sapiens 78-82 34208028-8 2021 In the mechanism, DNA-PK-Chk2 signaling was activated by ETO treatment; inhibition of this signaling cascade alleviated multiple ETO-induced centrosomes and primary cilia followed by reducing cellular senescence. Etoposide 57-60 checkpoint kinase 2 Homo sapiens 25-29 34208028-8 2021 In the mechanism, DNA-PK-Chk2 signaling was activated by ETO treatment; inhibition of this signaling cascade alleviated multiple ETO-induced centrosomes and primary cilia followed by reducing cellular senescence. Etoposide 129-132 checkpoint kinase 2 Homo sapiens 25-29 34208028-10 2021 Importantly, the inactivation of DNA-PK-Chk2 signaling reduced ETO-triggered autophagy; however, the inhibition of autophagy did not affect DNA-PK-Chk2 activation. Etoposide 63-66 checkpoint kinase 2 Homo sapiens 40-44 34208028-11 2021 Thus, ETO activated the DNA-PK-Chk2 cascade to facilitate autophagy. Etoposide 6-9 checkpoint kinase 2 Homo sapiens 31-35 26751770-7 2016 In response to DNA damage induced by etoposide, interaction between both proteins is disrupted, thus avoiding CHK2 degradation and promoting its stabilization. Etoposide 37-46 checkpoint kinase 2 Homo sapiens 110-114 26986476-8 2016 The results showed that knockdown of PTEN strongly antagonized ATM activation in response to etoposide treatment, and thereby reduced the phosphorylation level of ATM substrates, including H2AX, P53 and Chk2. Etoposide 93-102 checkpoint kinase 2 Homo sapiens 203-207 26690546-7 2015 Pharmacological inactivation of Chk2, CDK2 or ERK1/2 or depletion of CDK2 or Chk2 inhibited the centrosome amplification in ETO-treated ACT cells. Etoposide 124-127 checkpoint kinase 2 Homo sapiens 32-36 26690546-7 2015 Pharmacological inactivation of Chk2, CDK2 or ERK1/2 or depletion of CDK2 or Chk2 inhibited the centrosome amplification in ETO-treated ACT cells. Etoposide 124-127 checkpoint kinase 2 Homo sapiens 77-81 23089312-6 2012 The loss of Chk2 activation after etoposide treatment reduced apoptosis in the cells by downregulating the expression of E2F1 and Bax. Etoposide 34-43 checkpoint kinase 2 Homo sapiens 12-16 23000346-0 2013 Signaling crosstalk of FHIT, CHK2 and p38 in etoposide induced growth inhibition in MCF-7 cells. Etoposide 45-54 checkpoint kinase 2 Homo sapiens 29-33 23000346-4 2013 Since both CHK2 and FHIT are being influenced by DNA damage, we have evaluated the interplay of p38, CHK2 and FHIT in response to etoposide-induced cell death. Etoposide 130-139 checkpoint kinase 2 Homo sapiens 101-105 23000346-10 2013 Besides, etoposide induced p38 and CHK2 phosphorylation and reduced FHIT expression in a time-dependent manner. Etoposide 9-18 checkpoint kinase 2 Homo sapiens 35-39 23000346-13 2013 Inhibition of p38 kinase and CHK2 prevented etoposide induced alteration in FHIT expression. Etoposide 44-53 checkpoint kinase 2 Homo sapiens 29-33 23000346-14 2013 Furthermore, p38 inhibitors augmented etoposide-induced CHK2 phosphorylation. Etoposide 38-47 checkpoint kinase 2 Homo sapiens 56-60 23000346-15 2013 These results indicate that etoposide lowers FHIT expression and induces cell death via p38 and CHK2 phosphorylation. Etoposide 28-37 checkpoint kinase 2 Homo sapiens 96-100 23000346-16 2013 These results demonstrate a time dependent complex crosstalk of FHIT, p38 and CHK2 pathways in response to etoposide. Etoposide 107-116 checkpoint kinase 2 Homo sapiens 78-82 21037108-7 2010 Tubacin enhances DNA damage induced by etoposide or SAHA as indicated by increased accumulation of gammaH2AX and activation of the checkpoint kinase Chk2. Etoposide 39-48 checkpoint kinase 2 Homo sapiens 149-153 20637859-8 2010 Knockdown of either kinases significantly reduced ATM activation in response to etoposide treatment, and thereby attenuated phosphorylation of the ATM substrates, including the S139 of H2AX (gammaH2AX), p53 S15, and CHK2 T68. Etoposide 80-89 checkpoint kinase 2 Homo sapiens 216-220