PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26295158-8	2015	MRP2 expression involved an ATP-dependent stimulation of the MEK/ERK signaling pathway that was associated with an increase in relative resistance of Caco-2 cells to etoposide.	Etoposide	166-175	ATP binding cassette subfamily C member 2	Homo sapiens	0-4	
26295158-9	2015	Abolition of MRP2 expression using shRNA significantly reduced the protective effect of MRP2 toward etoposide as well as to cisplatin and doxorubicin.	Etoposide	100-109	ATP binding cassette subfamily C member 2	Homo sapiens	13-17	
26295158-9	2015	Abolition of MRP2 expression using shRNA significantly reduced the protective effect of MRP2 toward etoposide as well as to cisplatin and doxorubicin.	Etoposide	100-109	ATP binding cassette subfamily C member 2	Homo sapiens	88-92	
17704753-7	2007	Adenoviral delivery of the ABCC2 antisense construct resulted in a reduced IC(50) for doxorubicin (12-fold), vincristine (50-fold), cisplatin (25-fold) and etoposide (VP-16) (25-fold).	Etoposide	156-165	ATP binding cassette subfamily C member 2	Homo sapiens	27-32	
21923755-7	2012	Intracellular concentrations of etoposide equivalents (i.e. parent compound plus metabolites) were affected only to a minor extent by the absence or presence of OATP1B1/UGT1A1/MRP2.	Etoposide	32-41	ATP binding cassette subfamily C member 2	Homo sapiens	176-180	
21923755-8	2012	In contrast, apical accumulation of etoposide equivalents was significantly higher in monolayers of both cell lines expressing MRP2 (MDCK-OATP1B1-MRP2, MDCK-OATP1B1-UGT1A1-MRP2) compared with the single-transfected (OATP1B1) and the control cell line.	Etoposide	36-45	ATP binding cassette subfamily C member 2	Homo sapiens	127-131	
21923755-10	2012	Moreover, etoposide and possibly also its glucuronide are substrates of MRP2.	Etoposide	10-19	ATP binding cassette subfamily C member 2	Homo sapiens	72-76	
21923755-2	2012	However, limited data are available on transport of drugs (e.g. ezetimibe, etoposide) and their glucuronidated metabolites by human MRP2 in intact cell systems.	Etoposide	75-84	ATP binding cassette subfamily C member 2	Homo sapiens	132-136	
19201990-3	2009	Several of these therapeutic drugs, such as methotrexate, vincristine, and etoposide, are substrates of the multidrug resistance-associated protein 2 (MRP2).	Etoposide	75-84	ATP binding cassette subfamily C member 2	Homo sapiens	108-149	
19201990-3	2009	Several of these therapeutic drugs, such as methotrexate, vincristine, and etoposide, are substrates of the multidrug resistance-associated protein 2 (MRP2).	Etoposide	75-84	ATP binding cassette subfamily C member 2	Homo sapiens	151-155	
15849751-5	2005	Transport of 2 previously identified MRP2 substrates, etoposide and vinblastine, was likewise stimulated by probenecid.	Etoposide	54-63	ATP binding cassette subfamily C member 2	Homo sapiens	37-41	
10220572-12	1999	Human MRP2 overexpressed in HEK-293 cells enhanced the resistance to etoposide (4-fold), cisplatin (10-fold), doxorubicin (7.8-fold), and epirubicin (5-fold).	Etoposide	69-78	ATP binding cassette subfamily C member 2	Homo sapiens	6-10	
11901101-0	2002	Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT).	Etoposide	72-81	ATP binding cassette subfamily C member 2	Homo sapiens	269-274	
11901101-4	2002	Etoposide transport kinetics were concentration-dependent in the MDCKII-MDR1 and MDCKII-cMOAT cells.	Etoposide	0-9	ATP binding cassette subfamily C member 2	Homo sapiens	88-93	
11901101-7	2002	Moderate inhibition of etoposide efflux by leukotriene C4 (LTC4) was observed in MDCKII-cMOAT cells.	Etoposide	23-32	ATP binding cassette subfamily C member 2	Homo sapiens	88-93	
11901101-10	2002	The current results demonstrate that the secretory transport mechanism of etoposide involves multiple transporters, including Pgp and cMOAT but not MRP1.	Etoposide	74-83	ATP binding cassette subfamily C member 2	Homo sapiens	134-139	
11901101-11	2002	These results demonstrate that Pgp and cMOAT are involved in the intestinal secretory transport of etoposide.	Etoposide	99-108	ATP binding cassette subfamily C member 2	Homo sapiens	39-44	
16602625-6	2005	MRP2 induction by staurosporine and H-7 was shown to have phenotypic consequences in whole cells, rendering them more resistant to etoposide and increasing their ability to export calcein through the plasma membrane.	Etoposide	131-140	ATP binding cassette subfamily C member 2	Homo sapiens	0-4	
9350240-6	1997	Increased C-MOAT mRNA was also observed in 39.4% of resistant cell lines (41.2% in etoposide resistant cell lines and 37.5% in m-AMSA resistant cell lines).	Etoposide	83-92	ATP binding cassette subfamily C member 2	Homo sapiens	10-16