PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18174237-2	2008	Here, we showed that lack of Bcl-2-interacting mediator of cell death (Bim)(EL) protein expression, a BH3-only member of the Bcl-2 family proteins, conferred resistance of a T-ALL cell line, Sup-T1, to etoposide-induced apoptosis.	Etoposide	202-211	BCL2 like 11	Homo sapiens	29-69	
29584430-6	2018	One bicyclic peptide was shown to inhibit the interaction between a pro-apoptotic protein (Bim) and either endogenous Bcl2A1 or Mcl-1, to induce apoptosis of SKMel28 human melanoma cells, and to sensitize them for enhanced cell death by the anticancer drug etoposide.	Etoposide	257-266	BCL2 like 11	Homo sapiens	91-94	
30841958-9	2019	Since Bim and Noxa act as key proapoptotic proteins in mitochondrial apoptosis, miR-374a inhibitor was able to enhance the etoposide-induced apoptosis pathway in glioma.	Etoposide	123-132	BCL2 like 11	Homo sapiens	6-9	
18794804-4	2008	Here, we report that etoposide treatment dramatically upregulates the BH3-only proteins, Bim and Puma, in Hus1-deficient cells.	Etoposide	21-30	BCL2 like 11	Homo sapiens	89-92	
18794804-5	2008	Inhibition of either Bim or Puma expression in Hus1-knockout cells confers significant resistance to etoposide-induced apoptosis, whereas knockdown of both proteins results in further resistance, suggesting that Bim and Puma cooperate in sensitizing Hus1-deficient cells to etoposide treatment.	Etoposide	274-283	BCL2 like 11	Homo sapiens	212-215	
18794804-6	2008	Moreover, we found that Rad9 collaborates with Bim and Puma to sensitize Hus1-deficient cells to etoposide-induced apoptosis.	Etoposide	97-106	BCL2 like 11	Homo sapiens	47-50	
18794804-8	2008	Taken together, these results suggest that loss of Hus1 sensitizes cells to etoposide-induced apoptosis not only by inducing Bim and Puma expressions but also by releasing Rad9 into the cytosol to augment mitochondrial apoptosis.	Etoposide	76-85	BCL2 like 11	Homo sapiens	125-128	
22349704-3	2012	After knockdown of FOXO3 or expression of a dominant-negative FOXO3 mutant we observed that etoposide- and doxorubicin-induced elevation of cellular ROS depends on FOXO3 activation and induction of its transcriptional target BCL2L11 (Bim).	Etoposide	92-101	BCL2 like 11	Homo sapiens	225-232	
18794804-5	2008	Inhibition of either Bim or Puma expression in Hus1-knockout cells confers significant resistance to etoposide-induced apoptosis, whereas knockdown of both proteins results in further resistance, suggesting that Bim and Puma cooperate in sensitizing Hus1-deficient cells to etoposide treatment.	Etoposide	101-110	BCL2 like 11	Homo sapiens	21-24	
18794804-5	2008	Inhibition of either Bim or Puma expression in Hus1-knockout cells confers significant resistance to etoposide-induced apoptosis, whereas knockdown of both proteins results in further resistance, suggesting that Bim and Puma cooperate in sensitizing Hus1-deficient cells to etoposide treatment.	Etoposide	101-110	BCL2 like 11	Homo sapiens	212-215