PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21037108-2 2010 Here we show that chemical inhibition with the HDAC6-selective inhibitor tubacin significantly enhances cell death induced by the topoisomerase II inhibitors etoposide and doxorubicin and the pan-HDAC inhibitor SAHA (vorinostat) in transformed cells (LNCaP, MCF-7), an effect not observed in normal cells (human foreskin fibroblast cells). Etoposide 158-167 histone deacetylase 6 Homo sapiens 47-52 21037108-4 2010 Further, we show that down-regulation of HDAC6 expression by shRNA in LNCaP cells enhances cell death induced by etoposide, doxorubicin, and SAHA. Etoposide 113-122 histone deacetylase 6 Homo sapiens 41-46 22957056-3 2012 Previous studies showed that inhibition of HDAC6 induces DNA damage and sensitizes transformed cells to anti-tumor agents such as etoposide and doxorubicin. Etoposide 130-139 histone deacetylase 6 Homo sapiens 43-48