PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17252195-2 2007 Here, we show that upregulated Cyclin A/Cdk2 activity precedes the proteolytic cleavage of PARP and is correlated with the mitochondrial translocation of Bax and the loss of mitochondrial transmembrane potential (Deltapsim) during etoposide-induced apoptosis in human cervical adenocarcinoma (HeLa) cells. Etoposide 231-240 cyclin dependent kinase 2 Homo sapiens 40-44 17252195-3 2007 Etoposide-induced apoptotic cell death is efficiently prevented in cells that overexpress a dominant negative mutant of Cdk2 (Cdk2-dn) or p21(WAF1/CIP1), a specific Cdk inhibitor. Etoposide 0-9 cyclin dependent kinase 2 Homo sapiens 120-124 17252195-3 2007 Etoposide-induced apoptotic cell death is efficiently prevented in cells that overexpress a dominant negative mutant of Cdk2 (Cdk2-dn) or p21(WAF1/CIP1), a specific Cdk inhibitor. Etoposide 0-9 cyclin dependent kinase 2 Homo sapiens 126-130 17252195-5 2007 Disruption of the mitochondrial transmembrane potential in etoposide-induced cells is prevented in cells that overexpress Cdk2-dn or p21(WAF1/CIP1), while this transition is prominently promoted in Cyclin A-expressing cells. Etoposide 59-68 cyclin dependent kinase 2 Homo sapiens 122-126 17252195-6 2007 We screened for mitochondrial Cdk2 targets in the etoposide-induced cells and found that the mitochondrial level of Bax is elevated by more than three fold in etoposide-treated cells and this elevation is effectively prevented in cells expressing Cdk2-dn under the same conditions. Etoposide 50-59 cyclin dependent kinase 2 Homo sapiens 30-34 17252195-6 2007 We screened for mitochondrial Cdk2 targets in the etoposide-induced cells and found that the mitochondrial level of Bax is elevated by more than three fold in etoposide-treated cells and this elevation is effectively prevented in cells expressing Cdk2-dn under the same conditions. Etoposide 50-59 cyclin dependent kinase 2 Homo sapiens 247-251 17252195-6 2007 We screened for mitochondrial Cdk2 targets in the etoposide-induced cells and found that the mitochondrial level of Bax is elevated by more than three fold in etoposide-treated cells and this elevation is effectively prevented in cells expressing Cdk2-dn under the same conditions. Etoposide 159-168 cyclin dependent kinase 2 Homo sapiens 30-34 17252195-6 2007 We screened for mitochondrial Cdk2 targets in the etoposide-induced cells and found that the mitochondrial level of Bax is elevated by more than three fold in etoposide-treated cells and this elevation is effectively prevented in cells expressing Cdk2-dn under the same conditions. Etoposide 159-168 cyclin dependent kinase 2 Homo sapiens 247-251 26690546-0 2015 Chloroquine alleviates etoposide-induced centrosome amplification by inhibiting CDK2 in adrenocortical tumor cells. Etoposide 23-32 cyclin dependent kinase 2 Homo sapiens 80-84 14695446-0 2003 Human cytomegalovirus (HCMV) IE1 plays role in resistance to apoptosis with etoposide in cancer cell line by Cdk2 accumulation. Etoposide 76-85 cyclin dependent kinase 2 Homo sapiens 109-113 14695446-8 2003 Cellular expression of Cdk2 was increased in UMG1- 2 after etoposide treatment while the expression of E2F-1 in UMG1-2 was decreased as compared with that in U373MG. Etoposide 59-68 cyclin dependent kinase 2 Homo sapiens 23-27 31529315-9 2020 Moreover, it sensitized cells to the chemotherapeutic agents such as cisplatin, pemetrexed, and etoposide (VP-16), and this effect by dinaciclib may induce cell cycle arrest via abrogating CDK2 activity. Etoposide 96-105 cyclin dependent kinase 2 Homo sapiens 189-193 15561098-3 2005 Whereas exposure of human cells to topoisomerase inhibitors camptothecin, etoposide, or adriamycin resulted in rapid (within 1 h) activation of the pathway including degradation of the Cdc25A phosphatase and inhibition of cyclin E/CDK2 kinase activity, taxol failed to activate this checkpoint even after a prolonged treatment. Etoposide 74-83 cyclin dependent kinase 2 Homo sapiens 231-235 14695446-9 2003 The Cdk2 inhibitor, roscovitine, decreased the resistance to apoptosis on etoposide-treated UMG1-2. Etoposide 74-83 cyclin dependent kinase 2 Homo sapiens 4-8 26690546-7 2015 Pharmacological inactivation of Chk2, CDK2 or ERK1/2 or depletion of CDK2 or Chk2 inhibited the centrosome amplification in ETO-treated ACT cells. Etoposide 124-127 cyclin dependent kinase 2 Homo sapiens 38-42 26690546-7 2015 Pharmacological inactivation of Chk2, CDK2 or ERK1/2 or depletion of CDK2 or Chk2 inhibited the centrosome amplification in ETO-treated ACT cells. Etoposide 124-127 cyclin dependent kinase 2 Homo sapiens 69-73 23028682-4 2012 Cyclin A-Cdk2 catalyzed the phosphorylation of Rad9 at serine 328 in HeLa cells during apoptosis induced by etoposide, an inhibitor of topoisomeraseII. Etoposide 108-117 cyclin dependent kinase 2 Homo sapiens 9-13 20149834-2 2010 In this study, we applied a phospho-proteomic technique to screen target molecules of Cdk2 during etoposide-induced apoptosis. Etoposide 98-107 cyclin dependent kinase 2 Homo sapiens 86-90 20149834-5 2010 The cellular levels of these phosphoproteins were markedly reduced in the presence of etoposide in HeLa cells transfected with dominant negative mutant construct of Cdk2. Etoposide 86-95 cyclin dependent kinase 2 Homo sapiens 165-169 20149834-6 2010 Among the six candidate phosphoproteins, human triosephosphate isomerase (TPI), a glycolytic enzyme, was found to be a direct substrate of Cdk2 during etoposide-induced apoptosis. Etoposide 151-160 cyclin dependent kinase 2 Homo sapiens 139-143