PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29133590-4	2018	Intriguingly, Ca2+-dependent activation of AMPK in two different LKB1-null cancer cell lines caused G1-phase cell-cycle arrest, and enhanced cell viability/survival after etoposide treatment, with both effects being abolished by knockout of AMPK-alpha1 and alpha2.	Etoposide	171-180	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	43-47	
29133590-4	2018	Intriguingly, Ca2+-dependent activation of AMPK in two different LKB1-null cancer cell lines caused G1-phase cell-cycle arrest, and enhanced cell viability/survival after etoposide treatment, with both effects being abolished by knockout of AMPK-alpha1 and alpha2.	Etoposide	171-180	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	241-252	
29133590-6	2018	These results suggest that AMPK activation protects cells against etoposide by limiting entry into S-phase, where cells would be more vulnerable to genotoxic stress.Implications: These results reveal that the alpha1 isoform of AMPK promotes tumorigenesis by protecting cells against genotoxic stress, which may explain findings that the gene encoding AMPK-alpha1 (but not -alpha2) is amplified in some human cancers.	Etoposide	66-75	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	27-31	
29133590-6	2018	These results suggest that AMPK activation protects cells against etoposide by limiting entry into S-phase, where cells would be more vulnerable to genotoxic stress.Implications: These results reveal that the alpha1 isoform of AMPK promotes tumorigenesis by protecting cells against genotoxic stress, which may explain findings that the gene encoding AMPK-alpha1 (but not -alpha2) is amplified in some human cancers.	Etoposide	66-75	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	227-231	
22960274-0	2013	ATM and LKB1 dependent activation of AMPK sensitizes cancer cells to etoposide-induced apoptosis.	Etoposide	69-78	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	37-41	
22960274-1	2013	The present study aims to determine the effect of AMPK on etoposide-induced apoptosis of cancer cells.	Etoposide	58-67	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	50-54	
22960274-2	2013	Our results revealed that etoposide induced AMPK activation in prostate C4-2 cancer cells, an event that was attenuated by ATM siRNA.	Etoposide	26-35	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	44-48	
22960274-5	2013	Finally, etoposide displayed a potent pro-apoptotic effect in cancer cells with functional LKB1 and AMPK.	Etoposide	9-18	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	100-104	
21274505-6	2011	Furthermore, activation of p53 and AMPK was detected in etoposide-treated cells and inhibition of AMPK triggered apoptosis through suppression of autophagy.	Etoposide	56-65	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	35-39	
21274505-9	2011	Moreover, AMPK activation is clearly associated with etoposide-induced autophagy.	Etoposide	53-62	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	10-14	
29133590-2	2018	In this study, etoposide activates the alpha1 but not the alpha2 isoform of AMPK, primarily within the nucleus.	Etoposide	15-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	76-80