PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10732782-7 1999 Etoposide diminished the binding between Bax and Bcl-XL but this was restored by IL-4 and VCAM-1 triggered signals. Etoposide 0-9 BCL2 associated X, apoptosis regulator Homo sapiens 41-44 10367743-6 1999 RESULTS: Caspase activation, poly(ADP-ribose) polymerase degradation and Bax membrane insertion were initiated rapidly following etoposide removal, concomitantly with cell cycle arrest. Etoposide 129-138 BCL2 associated X, apoptosis regulator Homo sapiens 73-76 9713486-10 1998 Increased apoptotic responses were generally observed in cell lines that were sensitive to etoposide and this correlated with low ratios of Bcl-2/Bax protein. Etoposide 91-100 BCL2 associated X, apoptosis regulator Homo sapiens 146-149 9494534-9 1997 Expression of bcl-2 family members (bax, bcl-x) was modulated by fotemustine, etoposide and cisplatin. Etoposide 78-87 BCL2 associated X, apoptosis regulator Homo sapiens 36-39 31551763-4 2019 Our data suggested that DLD-1 colon cancer cells with BAX/BAK double-knockout were selectively resistant to a panel of FDA-approved drugs (27 out of 66), including etoposide. Etoposide 164-173 BCL2 associated X, apoptosis regulator Homo sapiens 54-57 9306577-0 1997 Overexpression of bax sensitizes breast cancer MCF-7 cells to cisplatin and etoposide. Etoposide 76-85 BCL2 associated X, apoptosis regulator Homo sapiens 18-21 8943258-1 1996 Bax, a member of the Bcl-2 family of proteins, has been shown to accelerate apoptosis induced by growth factor withdrawal, gamma-irradiation, and the chemotherapeutic agent, etoposide. Etoposide 174-183 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 8798452-0 1996 Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. Etoposide 33-42 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 34411980-11 2021 Combination studies revealed that both compounds had synergistic effects (combination index CI < 1) on Cis and Eto through induction of apoptosis (p53 activation and up-regulation of BAX and p21 gene expression). Etoposide 111-114 BCL2 associated X, apoptosis regulator Homo sapiens 183-186 8620501-0 1996 Hypersensitivity of human testicular tumors to etoposide-induced apoptosis is associated with functional p53 and a high Bax:Bcl-2 ratio. Etoposide 47-56 BCL2 associated X, apoptosis regulator Homo sapiens 120-123 34674796-5 2022 PEMFs elevated the etoposide-induced PARP cleavage and caspase-7/9 activation and enhanced the etoposide-induced down-regulation of survivin and up-regulation of Bax. Etoposide 95-104 BCL2 associated X, apoptosis regulator Homo sapiens 162-165 27419628-5 2016 The results showed that both glutamine deprivation and BPTES pretreatments increased the toxic effects of cisplatin and etoposide on HCC1937 cells, as demonstrated by their reduced proliferation, increased expression of apoptosis-related proteins (cleaved-PARP, cleaved-caspase 9, and cleaved-caspase 3) and decreased Bcl-2/BAX ratio. Etoposide 120-129 BCL2 associated X, apoptosis regulator Homo sapiens 324-327 30213983-4 2018 HTLA-ER cells, following etoposide exposure, evaded apoptosis by altering Bax/Bcl2 ratio. Etoposide 25-34 BCL2 associated X, apoptosis regulator Homo sapiens 74-77 23782464-6 2013 BAK/BAX double knockout HCT116 cells expressing a phosphor-mimetic BAK mutant (BAK Y110E), showed impaired dimerization and multimerization capacity when treated with either UV irradiation or etoposide when compared to cells reconstituted to express wild-type BAK. Etoposide 192-201 BCL2 associated X, apoptosis regulator Homo sapiens 4-7 25109285-8 2014 Sirt1-Foxp3 signaling-mediated regulation of Bax and p21 mRNA expression was a signature molecular event in TPC1 cells, which showed remarkable resistance to etoposide-induced genotoxic stress. Etoposide 158-167 BCL2 associated X, apoptosis regulator Homo sapiens 45-48 23161404-8 2013 Moreover, inhibition of GSK3 reduced etoposide-induced association of p53 with Bcl2 and Bax oligomerization. Etoposide 37-46 BCL2 associated X, apoptosis regulator Homo sapiens 88-91 22529100-5 2012 Accordingly, small interfering ribonucleic acid-mediated knockdown of Cdh1 stabilized MOAP-1, thereby enhancing etoposide-induced Bax activation and apoptosis. Etoposide 112-121 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 23089312-6 2012 The loss of Chk2 activation after etoposide treatment reduced apoptosis in the cells by downregulating the expression of E2F1 and Bax. Etoposide 34-43 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 22238053-11 2012 Treatment of AGS cells with 10 muM cisplatin, 0.5 muM etoposide and 10 nM taxol affected the BCL2, BAX and BCL2L12 mRNA levels, compared to the untreated cells. Etoposide 54-63 BCL2 associated X, apoptosis regulator Homo sapiens 99-102 22238053-12 2012 Cisplatin and etoposide induced a major down-regulation in the BCL2 mRNA levels after 72 h of treatment, while the BAX mRNA levels were slightly up-regulated. Etoposide 14-23 BCL2 associated X, apoptosis regulator Homo sapiens 115-118 22072718-8 2011 Further studies showed that overexpression of INrf2 enhanced degradation of PGAM5-Bcl-xL complex, led to etoposide-mediated accumulation of Bax, increased release of cytochrome c from mitochondria, activated caspase-3/7, and enhanced DNA fragmentation and apoptosis. Etoposide 105-114 BCL2 associated X, apoptosis regulator Homo sapiens 140-143 20226587-3 2010 Co-treatment of etoposide and KG-135 markedly elevated the expression and phosphorylation at the serine 15 residue of p53 as well as the cellular levels of Bax and p21(Waf1/Cip1). Etoposide 16-25 BCL2 associated X, apoptosis regulator Homo sapiens 156-159 20865015-4 2011 Further studies showed that INrf2 enhanced etoposide-mediated accumulation of Bax, increased release of cytochrome c from mitochondria, activated caspase-3/7, and enhanced DNA fragmentation and apoptosis. Etoposide 43-52 BCL2 associated X, apoptosis regulator Homo sapiens 78-81 20840860-6 2010 Downregulation of p53 target genes BAX and/or GADD45 alpha led to decreased in PPP1R13L activation after adriamycin and/or etoposide treatments. Etoposide 123-132 BCL2 associated X, apoptosis regulator Homo sapiens 35-38 20226587-5 2010 Moreover, co-treatment of etoposide and KG-135 enhanced mitochondrial localization of Bax. Etoposide 26-35 BCL2 associated X, apoptosis regulator Homo sapiens 86-89 20226587-6 2010 Our results indicate that etoposide-induced apoptosis in HeLa cells can be potentiated in the presence of KG-135 through a mechanism that involves the stabilization of p53 and the stimulation of Bax- and p21-mediated apoptotic signaling pathways. Etoposide 26-35 BCL2 associated X, apoptosis regulator Homo sapiens 195-198 19657228-8 2009 Overexpression of IFNgammaR2 (wild type and IFNgammaR2(296-337)) rescued cells from etoposide and staurosporine, which are known to induce Bax-mediated cell death. Etoposide 84-93 BCL2 associated X, apoptosis regulator Homo sapiens 139-142 20174550-10 2010 Bax redistribution was inhibited in both etoposide-induced and Bax-induced apoptosis by Ats-1. Etoposide 41-50 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 16709574-4 2006 Phosphorylation of Bax by JNK and p38 kinase activated after treatment with staurosporine, H(2)O(2), etoposide, and UV light was demonstrated by the shift in the pI value of Bax on two-dimensional gels and confirmed by metabolic labeling with inorganic [(32)P]phosphate in HepG2 cells. Etoposide 101-110 BCL2 associated X, apoptosis regulator Homo sapiens 19-22 18071312-4 2008 Co-treatment, but not single treatment, with VP16 and TSA induced apoptosis in a caspase-dependent manner accompanied by a crucial decrease in Bcl-xL expression allowing Bax activation and subsequent initiation of the apoptosis inducing factor (AIF)-dependent death pathway. Etoposide 45-49 BCL2 associated X, apoptosis regulator Homo sapiens 170-173 18330707-5 2008 ISG12a enhanced etoposide induced cytochrome c release, Bax activation and loss of mitochondrial membrane potential. Etoposide 16-25 BCL2 associated X, apoptosis regulator Homo sapiens 56-59 19271688-0 2008 Quantitative analysis of expression level of BCL2 and BAX genes in Hep-2 and HL-60 cells after treatment with etoposide. Etoposide 110-119 BCL2 associated X, apoptosis regulator Homo sapiens 54-57 19271688-6 2008 In HL-60 cells the expression level of BCL2 decreased after 6 h of treatment and expression of BAX increased both 6 h and 12 h of treatment with etoposide. Etoposide 145-154 BCL2 associated X, apoptosis regulator Homo sapiens 95-98 17252195-6 2007 We screened for mitochondrial Cdk2 targets in the etoposide-induced cells and found that the mitochondrial level of Bax is elevated by more than three fold in etoposide-treated cells and this elevation is effectively prevented in cells expressing Cdk2-dn under the same conditions. Etoposide 50-59 BCL2 associated X, apoptosis regulator Homo sapiens 116-119 17252195-6 2007 We screened for mitochondrial Cdk2 targets in the etoposide-induced cells and found that the mitochondrial level of Bax is elevated by more than three fold in etoposide-treated cells and this elevation is effectively prevented in cells expressing Cdk2-dn under the same conditions. Etoposide 159-168 BCL2 associated X, apoptosis regulator Homo sapiens 116-119 16895478-0 2006 Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS. Etoposide 40-49 BCL2 associated X, apoptosis regulator Homo sapiens 139-142 16895478-3 2006 In the case of etoposide, down-regulation of the BCL2L12-A gene variant and of CASPASE-9, as well as upregulation of BAX, was observed, whereas treatment of MCF-7 cells with taxol led to down-regulation of the mRNA levels of all genes examined. Etoposide 15-24 BCL2 associated X, apoptosis regulator Homo sapiens 117-120 18366759-8 2008 Cluster analysis of data unravels several possible pathways involved in the hypoxia-induced protection against etoposide-induced apoptosis: one of them could be the inhibition of p53 activity under hypoxia since caspase 3 activity parallels Bax and Bak expression profile. Etoposide 111-120 BCL2 associated X, apoptosis regulator Homo sapiens 241-244 16709574-4 2006 Phosphorylation of Bax by JNK and p38 kinase activated after treatment with staurosporine, H(2)O(2), etoposide, and UV light was demonstrated by the shift in the pI value of Bax on two-dimensional gels and confirmed by metabolic labeling with inorganic [(32)P]phosphate in HepG2 cells. Etoposide 101-110 BCL2 associated X, apoptosis regulator Homo sapiens 174-177 16547931-0 2006 The course of etoposide-induced apoptosis in Jurkat cells lacking p53 and Bax. Etoposide 14-23 BCL2 associated X, apoptosis regulator Homo sapiens 74-77 16325212-5 2006 Moreover, ectopic expression of p33ING1b markedly upregulated p53, p21WAF1 and bax protein levels and activated caspase-3 protein kinase in etoposide-treated U2OS cells. Etoposide 140-149 BCL2 associated X, apoptosis regulator Homo sapiens 79-82 16211087-3 2006 Constitutive expression of Smac resulted in enhanced Bax accumulation on mitochondria upon etoposide stimulation and inhibited Bcl-2-induced antiapoptosis activity. Etoposide 91-100 BCL2 associated X, apoptosis regulator Homo sapiens 53-56 16297990-13 2006 The ratio Bcl-2/Bax was reduced in parental or mock-transfected PC-3 cells after treatment with etoposide. Etoposide 96-105 BCL2 associated X, apoptosis regulator Homo sapiens 16-19 15388581-4 2005 Ectopic expression of hsp70 in HL-60 cells (HL-60/hsp70) inhibited Ara-C and etoposide-induced Bax conformation change and translocation to the mitochondria; attenuated the accumulation of cytochrome c, Smac, and Omi/HtrA2 in the cytosol; and inhibited the processing and activity of caspase-9 and caspase-3. Etoposide 77-86 BCL2 associated X, apoptosis regulator Homo sapiens 95-98 15191662-11 2004 CONCLUSION: These observations suggest that p33(ING1b) up-regulates p53 protein, and cooperate with p53 in stimulating expression of p21(WAF1) and Bax gene, thus to enhance etoposide-induced apoptosis via p53-dependent pathways. Etoposide 173-182 BCL2 associated X, apoptosis regulator Homo sapiens 147-150 12063570-9 2002 Further studies in this area are warranted as the roles of p21WAF1, Bax/Bcl-2 and NF-kappaB may be important molecular events in mediating the antiproliferative and apoptosis inducing effect of etoposide in combination with ciprofloxacin in HRPC cells. Etoposide 194-203 BCL2 associated X, apoptosis regulator Homo sapiens 68-71 12823542-0 2003 Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703. Etoposide 0-9 BCL2 associated X, apoptosis regulator Homo sapiens 22-25 12823542-3 2003 In dissecting the mechanism underlying this synergistic effect, we found that treatment with etoposide alone resulted in the upregulation of Bax, while the level of truncated Bid (tBid) was unchanged. Etoposide 93-102 BCL2 associated X, apoptosis regulator Homo sapiens 141-144 11521193-0 2001 Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis. Etoposide 71-80 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 12065845-14 2002 However, a Bax cleavage product was noted which was substantially increased by cotreatment with ROS or etoposide. Etoposide 103-112 BCL2 associated X, apoptosis regulator Homo sapiens 11-14 11864976-4 2002 The activation of p53 by etoposide resulted in the up-regulation of the pro-apoptotic protein Bax, a result that was prevented by the protein synthesis inhibitor cycloheximide. Etoposide 25-34 BCL2 associated X, apoptosis regulator Homo sapiens 94-97 11911275-6 2001 MG-132 was found to be more effective in combination with drugs such as doxorubicin and etoposide that act in the S/G2-phase of the cell cycle via a mechanism that involves stabilization of cyclin B1 and increased expression of Bax. Etoposide 88-97 BCL2 associated X, apoptosis regulator Homo sapiens 228-231 11848465-6 2001 HA-bax clones were significantly more sensitive to cell death induction by cis-diamminedichloroplatinum, etoposide, doxorubicin and gamma-radiation than vector control cells. Etoposide 105-114 BCL2 associated X, apoptosis regulator Homo sapiens 3-6 11513857-6 2001 However, subsequent exposure of CCCP-treated cells to etoposide or staurosporine for 48 h results in rapid cell death and cytochrome c release that is accompanied by Bax association with mitochondria, demonstrating competency of these mitochondria to release cytochrome c with additional triggers. Etoposide 54-63 BCL2 associated X, apoptosis regulator Homo sapiens 166-169 11521193-5 2001 Bax up-regulation occurred at the whole cell level after DNA damage induced by etoposide. Etoposide 79-88 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 11521193-6 2001 However, after incubation with etoposide, Bax failed to translocate to mitochondria and as a result, the apoptotic process was blocked. Etoposide 31-40 BCL2 associated X, apoptosis regulator Homo sapiens 42-45 11521193-10 2001 The increased levels of mitochondrial Bax sensitized cells to etoposide-induced activation of caspases-2, -3 and -9 and apoptosis. Etoposide 62-71 BCL2 associated X, apoptosis regulator Homo sapiens 38-41 11521193-11 2001 However, after transient transfection with the Apaf-1 gene, K/Bax cells were sensitized to etoposide-induced caspase activation and apoptosis to a larger extent compared with Bax or Apaf-1 transfection alone. Etoposide 91-100 BCL2 associated X, apoptosis regulator Homo sapiens 62-65 11521193-12 2001 We therefore conclude that two mechanisms contribute to the resistance of K562 cells to etoposide-induced apoptosis; firstly failure of Bax targeting to mitochondria and, secondly, deficiency of Apaf-1. Etoposide 88-97 BCL2 associated X, apoptosis regulator Homo sapiens 136-139 11521193-13 2001 Uncoupling of Bax translocation from Bax induction can occur in response to etoposide-induced DNA damage. Etoposide 76-85 BCL2 associated X, apoptosis regulator Homo sapiens 14-17 11521193-13 2001 Uncoupling of Bax translocation from Bax induction can occur in response to etoposide-induced DNA damage. Etoposide 76-85 BCL2 associated X, apoptosis regulator Homo sapiens 37-40 11487718-3 2001 In the present study subcellular BAX translocations in human colon adenocarcinoma COLO 205 cells exposed to various anticancer drugs [camptothecin (CPT), etoposide (ETO), staurosporine (STP), 2-chloro-2"-deoxyadenosine (2CdA) and nimesulide (NIM)] was examined. Etoposide 154-163 BCL2 associated X, apoptosis regulator Homo sapiens 33-36 11487718-3 2001 In the present study subcellular BAX translocations in human colon adenocarcinoma COLO 205 cells exposed to various anticancer drugs [camptothecin (CPT), etoposide (ETO), staurosporine (STP), 2-chloro-2"-deoxyadenosine (2CdA) and nimesulide (NIM)] was examined. Etoposide 165-168 BCL2 associated X, apoptosis regulator Homo sapiens 33-36 11487718-12 2001 It was shown that BAX Nf increased in cells treated with CPT, STP, ETO, 2CdA and NIM, whereas BAX Cf rose after STP and NIM. Etoposide 67-70 BCL2 associated X, apoptosis regulator Homo sapiens 18-21 11355877-1 2001 We have previously shown that Bax translocation was crucial in TNFalpha or etoposide-induced apoptosis. Etoposide 75-84 BCL2 associated X, apoptosis regulator Homo sapiens 30-33 11484935-3 2001 As revealed by immunoblotting, bax protein was expressed in HUVECs treated with 1 mg/ml etoposide whereas bcl-2 protein disappeared. Etoposide 88-97 BCL2 associated X, apoptosis regulator Homo sapiens 31-34 11355877-2 2001 Overexpression of Bax sensitized chronic myeloid leukemic K562 cells to etoposide-induced apoptosis. Etoposide 72-81 BCL2 associated X, apoptosis regulator Homo sapiens 18-21 11029754-3 2000 Here we report that before the initiation of apoptotic execution by etoposide or staurosporin, an active calpain activity cleaves Bax at its N-terminus, generating a potent proapoptotic 18-kDa fragment (Bax/p18). Etoposide 68-77 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 10996201-5 2000 These data indicate that abrogation of bax-mediated apoptosis can be implicated in development of etoposide resisance. Etoposide 98-107 BCL2 associated X, apoptosis regulator Homo sapiens 39-42 11401473-6 2001 Accumulation of P53 and its target gene bax then sensitized HeLa cells to cell-cycle arrest, cell death/apoptosis induced by cisplatin, and etoposide. Etoposide 140-149 BCL2 associated X, apoptosis regulator Homo sapiens 40-43 11042671-9 2000 Taken together, these results suggest that ceramide may function as a mediator of etoposide-induced apoptosis of C6 glioma cells, which induces increase in the Bax/Bcl-2 ratio followed by release of cytochrome c leading to caspases-9 and -3 activation. Etoposide 82-91 BCL2 associated X, apoptosis regulator Homo sapiens 160-163 11042671-0 2000 Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells. Etoposide 84-93 BCL2 associated X, apoptosis regulator Homo sapiens 56-59 11042671-4 2000 In addition, exposure of cells to etoposide resulted in decreased expression of Bcl-2 with reciprocal increase in Bax protein. Etoposide 34-43 BCL2 associated X, apoptosis regulator Homo sapiens 114-117 11042671-6 2000 Reduced glutathione or N-acetylcysteine, which could reduce ceramide formation by inhibiting sphingomyelinase activity, prevented C6 cells from etoposide-induced apoptosis through blockage of caspase-3 activation and change of the Bax/Bcl-2 ratio. Etoposide 144-153 BCL2 associated X, apoptosis regulator Homo sapiens 231-234 10839193-8 2000 The downregulation of Bcl-X(L) protein occurred from 6 h, while Bax protein conversely showed a slight increase from 6 h. Taken together, the present findings show that the dose-dependent apoptotic effect of etoposide is based on a change in the balance between Bcl-X(L) and Bax, which precedes the activation of caspase-3. Etoposide 208-217 BCL2 associated X, apoptosis regulator Homo sapiens 64-67 10918609-5 2000 Bax overexpression enhanced etoposide-induced apoptosis through acceleration of cytochrome c release and caspases activation. Etoposide 28-37 BCL2 associated X, apoptosis regulator Homo sapiens 0-3 10839193-8 2000 The downregulation of Bcl-X(L) protein occurred from 6 h, while Bax protein conversely showed a slight increase from 6 h. Taken together, the present findings show that the dose-dependent apoptotic effect of etoposide is based on a change in the balance between Bcl-X(L) and Bax, which precedes the activation of caspase-3. Etoposide 208-217 BCL2 associated X, apoptosis regulator Homo sapiens 275-278 10620629-0 2000 Epigenetic determinants of resistance to etoposide regulation of Bcl-X(L) and Bax by tumor microenvironmental factors. Etoposide 41-50 BCL2 associated X, apoptosis regulator Homo sapiens 78-81 10620629-12 2000 VCAM-1- and interleukin 4-mediated signals diminished conformational changes in Bax protein and prevented the etoposide-induced disruption of constitutive Bax-Bcl-x(L) binding. Etoposide 110-119 BCL2 associated X, apoptosis regulator Homo sapiens 80-83 10620629-12 2000 VCAM-1- and interleukin 4-mediated signals diminished conformational changes in Bax protein and prevented the etoposide-induced disruption of constitutive Bax-Bcl-x(L) binding. Etoposide 110-119 BCL2 associated X, apoptosis regulator Homo sapiens 155-158 10620629-13 2000 CONCLUSIONS: Microenvironmental factors reduce the sensitivity of a B-cell lymphoma to etoposide in vitro by modulating the expression and functions of Bax and Bcl-x(L). Etoposide 87-96 BCL2 associated X, apoptosis regulator Homo sapiens 152-155 10554032-4 1999 We found that both endogenous and exogenous added recombinant Bax translocated to the mitochondria more efficiently in the presence of cytosol from cells with VP16-induced apoptosis than with cytoplasm from normal cells. Etoposide 159-163 BCL2 associated X, apoptosis regulator Homo sapiens 62-65 10769693-3 2000 Apoptosis in the bax-transfected gastric cancer cells was enhanced following the treatment of various chemotherapeutic agents including adriamycin (ADM), cisplatin (CDDP), etoposide (VP-16) and taxotere (TXT) as compared to those of neo gene-transfected cells. Etoposide 172-181 BCL2 associated X, apoptosis regulator Homo sapiens 17-20 10713725-3 2000 In this report we demonstrate by subcellular fractionation a significant shift in Bax localization from cytosol to cellular membranes in two human tumor cell lines exposed to staurosporine or etoposide. Etoposide 192-201 BCL2 associated X, apoptosis regulator Homo sapiens 82-85 10381626-2 1999 Exposure of undifferentiated U937 cells to 50 microM etoposide for 6 h, that triggers apoptosis in 80% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Mcl-1 expression without modifying Bcl-2, Bcl-xL and Bax protein levels. Etoposide 53-62 BCL2 associated X, apoptosis regulator Homo sapiens 263-266