PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18080832-10	2008	The activation of caspase-3 preceded the cleavage of PKR after serum withdrawal, anisomycin and etoposide treatment, while coincided with it in cells treated with LY294002 or cisplatin.	Etoposide	96-105	caspase 3	Rattus norvegicus	18-27	
23054080-0	2013	Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic beta-cells.	Etoposide	20-29	caspase 3	Rattus norvegicus	38-47	
23054080-3	2013	We report herein that exposure of insulin-secreting INS 832/13 cells or normal rat islets to etoposide leads to significant activation of caspase-3 and subsequent degradation of the common alpha-subunit of farnesyl/geranylgeranyl transferases (FTase/GGTase).	Etoposide	93-102	caspase 3	Rattus norvegicus	138-147	
23054080-6	2013	Moreover, nifedipine, a calcium channel blocker, markedly attenuated etoposide-induced caspase-3 activation, FTase/GGTase alpha-subunit degradation in INS 832/13 cells and normal rat islets.	Etoposide	69-78	caspase 3	Rattus norvegicus	87-96	
23054080-8	2013	Based on these findings, we conclude that etoposide induces loss in cell viability by inducing mitochondrial dysfunction, caspase-3 activation and degradation of FTase/GGTase alpha-subunit.	Etoposide	42-51	caspase 3	Rattus norvegicus	122-131	
20519366-11	2010	Moreover, caspases-3, -8, -9 activation and germ cell death induced by etoposide were significantly decreased by these drugs.	Etoposide	71-80	caspase 3	Rattus norvegicus	10-28	
27473919-3	2016	Here, the results showed that in RIN-m5F cells (a beta-cell-derived cell line), the number of viable cells was significantly decreased after 24h of etoposide treatment and underwent mitochondria-dependent apoptotic signals accompanied by mitochondrial dysfunction, and increases in the population of sub-G1 hypodiploid cells and apoptotic cells, caspase-3 activity, and the activation of caspase cascades.	Etoposide	148-157	caspase 3	Rattus norvegicus	346-355	
15906374-7	2005	Simultaneously, the dissociated Hip-1 from Dyrk1 bound to caspase-3 in response to etoposide, which led to its activation and consequently cell death in H19-7 cells.	Etoposide	83-92	caspase 3	Rattus norvegicus	58-67	
16644697-7	2006	In contrast, camptothecin- and etoposide-induced killing is associated with robust increases in caspase 3 activation and annexin V staining.	Etoposide	31-40	caspase 3	Rattus norvegicus	96-105	
10712510-2	2000	We investigated the changes in focal adhesion proteins during etoposide-induced apoptosis in Rat-1 cells and found that during apoptosis, p130cas (Crk-associated substrate [Cas]) is cleaved by caspase-3.	Etoposide	62-71	caspase 3	Rattus norvegicus	193-202	
12700634-2	2003	IGF1 significantly suppressed etoposide-induced apoptosis, measured by caspase 3 activation and quantitation of cellular subG(1) DNA content, in rat parotid salivary acinar cells (C5).	Etoposide	30-39	caspase 3	Rattus norvegicus	71-80	
11511102-3	2001	In Rat-1 cells, cleavage of paxillin by caspase-3 was suppressed by zVAD-fmk or zDEVD-cmk, making caspase-3 a likely executioner during etoposide-induced apoptosis.	Etoposide	136-145	caspase 3	Rattus norvegicus	40-49	
11511102-3	2001	In Rat-1 cells, cleavage of paxillin by caspase-3 was suppressed by zVAD-fmk or zDEVD-cmk, making caspase-3 a likely executioner during etoposide-induced apoptosis.	Etoposide	136-145	caspase 3	Rattus norvegicus	98-107	
12009851-9	2002	Caspase 3 activity was markedly increased by the three apoptosis inducers; caspase 6 was only activated by MPS and etoposide, while caspase 8 was not activated by any of these inducers.	Etoposide	115-124	caspase 3	Rattus norvegicus	0-9	
10383415-1	1999	We have previously shown that parotid C5 salivary acinar cells undergo apoptosis in response to etoposide treatment as indicated by alterations in cell morphology, caspase-3 activation, DNA fragmentation, sustained activation of c-Jun N-terminal kinase, and inactivation of extracellular regulated kinases 1 and 2.	Etoposide	96-105	caspase 3	Rattus norvegicus	164-173