PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28187857-1 2017 BACKGROUND: Kynurenine 3-monooxygenase converts kynurenine to 3-hydroxykynurenine, and its inhibition shunts the kynurenine pathway-which is implicated as dysfunctional in various psychiatric disorders-toward enhanced synthesis of kynurenic acid, an antagonist of both alpha7 nicotinic acetylcholine and N-methyl-D-aspartate receptors. Kynurenic Acid 231-245 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 12-38 30760699-3 2019 We show that KMO is highly expressed in the kidney and exerts major metabolic control over the biologically active kynurenine metabolites 3-hydroxykynurenine, kynurenic acid, and downstream metabolites. Kynurenic Acid 159-173 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 13-16 30354938-2 2018 Elevated kynurenic acid in schizophrenia may be secondary to a genetic alteration of kynurenine 3-monooxygenase, a pivotal enzyme in the kynurenine pathway of tryptophan degradation. Kynurenic Acid 9-23 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 85-111 30354938-6 2018 RESULTS:: Maternal kynurenine treatment raised kynurenic acid levels significantly more in the brain of heterozygous offspring of Kmo+/- than in the brain of Kmo+/+ offspring. Kynurenic Acid 47-61 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 130-133 30354938-9 2018 Kynurenine treatment also caused a preferential elevation in cerebral kynurenic acid levels in Kmo+/- compared to Kmo+/+ dams. Kynurenic Acid 70-84 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 95-98 30354938-10 2018 CONCLUSIONS:: The disproportionate kynurenic acid increase in the brain of Kmo+/- animals indicates that the maternal Kmo genotype may play a key role in the pathophysiology of schizophrenia. Kynurenic Acid 35-49 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 75-78 30354938-10 2018 CONCLUSIONS:: The disproportionate kynurenic acid increase in the brain of Kmo+/- animals indicates that the maternal Kmo genotype may play a key role in the pathophysiology of schizophrenia. Kynurenic Acid 35-49 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 118-121 29879409-2 2018 Inhibition of KMO increases kynurenine, resulting in elevated levels of kynurenic acid (KYNA), an endogenous N-methyl-d-aspartate and alpha*7-nicotinic receptor antagonist. Kynurenic Acid 72-86 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 14-17 29879409-2 2018 Inhibition of KMO increases kynurenine, resulting in elevated levels of kynurenic acid (KYNA), an endogenous N-methyl-d-aspartate and alpha*7-nicotinic receptor antagonist. Kynurenic Acid 88-92 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 14-17 34483669-5 2021 However, administration of PF-04859989, a kynurenine aminotransferase (KAT) II inhibitor, limiting the production of KYNA, facilitated fEPSP and enhanced LTP to a greater extent in hippocampal slices from KMO-/- mice compared to WT mice. Kynurenic Acid 117-121 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 205-208 35204197-1 2022 Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). Kynurenic Acid 191-205 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 35204197-1 2022 Kynurenine 3-monooxygenase (KMO), a key player in the kynurenine pathway (KP) of tryptophan degradation, regulates the synthesis of the neuroactive metabolites 3-hydroxykynurenine (3-HK) and kynurenic acid (KYNA). Kynurenic Acid 191-205 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 34054556-8 2021 Expression of indoleamine 2,3-dioxygenase 2 (IDO2) and kynurenine 3-monooxygenase (KMO) was increased by poly (I:C) whereas kynurenine aminotransferase II and its metabolite kynurenic acid were not altered. Kynurenic Acid 174-188 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 55-81 34054556-8 2021 Expression of indoleamine 2,3-dioxygenase 2 (IDO2) and kynurenine 3-monooxygenase (KMO) was increased by poly (I:C) whereas kynurenine aminotransferase II and its metabolite kynurenic acid were not altered. Kynurenic Acid 174-188 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 83-86 33607168-0 2021 Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of alpha7 nicotinic acetylcholine receptors by kynurenic acid. Kynurenic Acid 142-156 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 0-26 33750843-5 2021 KP metabolites were also assessed, and KMO depletion led to increased levels of neuroprotective kynurenic acid in brain and periphery, and dramatically reduced neurotoxic 3-hydroxykunurenine levels in striatum and cortex. Kynurenic Acid 96-110 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 39-42 28187857-5 2017 Kynurenic acid levels were also increased in these brain regions in Kmo-/- mice, with significantly higher levels in the cerebellum than in the cerebrum. Kynurenic Acid 0-14 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 68-71 28709913-5 2017 The SNI-induced increase of Kmo mRNA was associated with increased KMO protein and elevated quinolinic acid and reduced kynurenic acid in the contralateral hippocampus. Kynurenic Acid 120-134 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 28-31 24189070-7 2013 When assessed by in vivo microdialysis, extracellular kynurenic acid levels were found to be significantly elevated in the brains of Kmo(-/-) mice. Kynurenic Acid 54-68 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 133-136 17559418-9 2008 The Kmo gene encodes kynurenine 3-hydroxylase, an enzyme-regulating metabolism of kynurenic acid, a glutamate antagonist with neuroprotective actions. Kynurenic Acid 82-96 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 4-7 17559418-9 2008 The Kmo gene encodes kynurenine 3-hydroxylase, an enzyme-regulating metabolism of kynurenic acid, a glutamate antagonist with neuroprotective actions. Kynurenic Acid 82-96 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) Mus musculus 21-45