PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34296297-7	2021	It was identified that the inhibition of PTP1B prevented ER stress caused by DTT and TG.	Dithiothreitol	77-80	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	41-46	
17081112-3	2006	PTPase activities of PTP1B or CD45 were abolished by low concentrations of (1)O(2), but were largely restored by post-treatment with dithiothreitol.	Dithiothreitol	133-147	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	21-26	
25907367-6	2015	Deactivation of PTP1B proceeds without covalent crosslinking of the protein target with the photo-switched inhibitors and can be reverted by subsequent addition of reducing agent dithiothreitol (DTT).	Dithiothreitol	179-193	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	16-21	
25907367-6	2015	Deactivation of PTP1B proceeds without covalent crosslinking of the protein target with the photo-switched inhibitors and can be reverted by subsequent addition of reducing agent dithiothreitol (DTT).	Dithiothreitol	195-198	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	16-21	
23957891-7	2013	The biological thiol glutathione repaired oxidized PTP1B with an apparent second-order rate constant of 0.023 +- 0.004 M(-1) s(-1), while the dithiol dithiothreitol (DTT) displayed an apparent second-order rate constant of 0.325 +- 0.007 M(-1) s(-1).	Dithiothreitol	166-169	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	51-56	
23957891-8	2013	The enzyme thioredoxin regenerated the catalytic activity of oxidized PTP1B at a substantially faster rate than DTT.	Dithiothreitol	112-115	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	70-75	
23957891-10	2013	The rates at which these agents regenerated oxidized PTP1B followed the order Trx > DTT > GSHand comparable values observed at 2 muM Trx, 4 mM DTT, and 60 mM GSH.	Dithiothreitol	87-90	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	53-58	
23957891-10	2013	The rates at which these agents regenerated oxidized PTP1B followed the order Trx > DTT > GSHand comparable values observed at 2 muM Trx, 4 mM DTT, and 60 mM GSH.	Dithiothreitol	149-152	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	53-58	
17714694-7	2007	Data on membrane localization, Mg2+ dependence, sensitivity to thiol oxidizing agents and protection by N-acetylcysteine (NAC) and DTT strongly suggest the involvement of PTP1B, the major PTP of human RBC associated to and acting on Band 3.	Dithiothreitol	131-134	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	171-176	
11739472-5	2001	Interestingly, the total PTPase activity from both adipose depots and the specific activity of PTP1B was increased by 42-71% after reduction in vitro with dithiothreitol, indicating that a major fraction of the cellular PTPase activity can be reactivated by sulfhydryl reduction.	Dithiothreitol	155-169	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	95-100	
10574916-8	1999	This step is prevented by glutathionylation of the sulfenic derivative to form a S-glutathionylated PTP-1B, which can be reactivated by dithiothreitol or thioltransferase.	Dithiothreitol	136-150	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	100-106