PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8049427-5 1994 DTT has been shown to expose the fibrinogen receptor on normal platelets. Dithiothreitol 0-3 fibrinogen beta chain Homo sapiens 33-43 8049427-6 1994 DTT treatment of GTV platelets did result in the formation of the fibrinogen binding site as indicated by the binding of pI-55, an MoAb that only binds to the activated form of alpha IIb beta 3. Dithiothreitol 0-3 fibrinogen beta chain Homo sapiens 66-76 8049427-7 1994 Furthermore, DTT-treated GTV platelets aggregated in the presence of fibrinogen and divalent cations. Dithiothreitol 13-16 fibrinogen beta chain Homo sapiens 69-79 8401394-9 1993 Calcium binding would protect Fbg in terms of structural alteration as well as S-S cleavage by both dithiothreitol (DTT) and cis-DDP. Dithiothreitol 116-119 fibrinogen beta chain Homo sapiens 30-33 6232725-2 1984 showed that over 1 mM dithiothreitol (DTT) aggregates blood platelets in the presence of fibrinogen; aggregation is not inhibited by prostaglandin E1. Dithiothreitol 22-36 fibrinogen beta chain Homo sapiens 89-99 3983914-10 1985 We also observed that the clotting of fibrinogen by thrombin was perturbed by DTT. Dithiothreitol 78-81 fibrinogen beta chain Homo sapiens 38-48 3983914-11 1985 Preincubation of fibrinogen with calcium ions prevented this effect of DTT. Dithiothreitol 71-74 fibrinogen beta chain Homo sapiens 17-27 3096886-8 1986 The number of fibrinogen-binding sites per cell varies from 500 to 1,500 in different batches of bacteria, and the dissociation constant for the complex is on the order of 10(-8) M. B. gingivalis possesses cell-associated fibrinogenolytic activity that is activated by dithiothreitol and blocked by thiol protease inhibitors. Dithiothreitol 269-283 fibrinogen beta chain Homo sapiens 14-24 2897211-0 1988 Ligation of fibrinogen by factor XIIIa with dithiothreitol: mechanical properties of ligated fibrinogen gels. Dithiothreitol 44-58 fibrinogen beta chain Homo sapiens 12-22 2897211-0 1988 Ligation of fibrinogen by factor XIIIa with dithiothreitol: mechanical properties of ligated fibrinogen gels. Dithiothreitol 44-58 fibrinogen beta chain Homo sapiens 93-103 6232725-2 1984 showed that over 1 mM dithiothreitol (DTT) aggregates blood platelets in the presence of fibrinogen; aggregation is not inhibited by prostaglandin E1. Dithiothreitol 38-41 fibrinogen beta chain Homo sapiens 89-99 6232725-6 1984 Platelets stimulated with DTT bound 125I-labeled fibrinogen. Dithiothreitol 26-29 fibrinogen beta chain Homo sapiens 49-59 6232725-7 1984 Thus DTT appears to "expose" the fibrinogen receptors. Dithiothreitol 5-8 fibrinogen beta chain Homo sapiens 33-43 9192939-7 1997 In contrast, DTT-treated sputum had higher total cell counts (median 8.8 vs 2.8 x 10(6) mL(-1); p<0.001) and levels of ECP (median 1340 vs 584 mg x L(-1); p<0.001) The measurements were similar with respect to the proportion of eosinophils, neutrophils, lymphocytes, macrophages, and fluid-phase fibrinogen, IL-5 and IL-8. Dithiothreitol 13-16 fibrinogen beta chain Homo sapiens 302-312 15583747-6 2004 A distinct feature of these cells is the failure of DTT to enhance the binding to soluble Fg and the formation of cell aggregates. Dithiothreitol 52-55 fibrinogen beta chain Homo sapiens 90-92 11313253-9 2001 Platelets from the thrombasthenic patient expressing [674R]GPIIb-IIIa were found to bind soluble fibrinogen in response to physiologic agonists or dithiothreitol treatment. Dithiothreitol 147-161 fibrinogen beta chain Homo sapiens 97-107 7482417-3 1995 The present study compared fibrinogen binding and platelet aggregation in response to dithiothreitol (DTT) and ADP. Dithiothreitol 86-100 fibrinogen beta chain Homo sapiens 27-37 7482417-3 1995 The present study compared fibrinogen binding and platelet aggregation in response to dithiothreitol (DTT) and ADP. Dithiothreitol 102-105 fibrinogen beta chain Homo sapiens 27-37 7482417-4 1995 DTT induced saturable and specific fibrinogen binding (Kd 0.07 + 0.02 microM, Bmax 15,000 + 3000 molecules/platelet) which supported complete platelet aggregation as determined by single platelet counting. Dithiothreitol 0-3 fibrinogen beta chain Homo sapiens 35-45 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Dithiothreitol 73-76 fibrinogen beta chain Homo sapiens 53-63 7482417-6 1995 Unlike fibrinogen bound to ADP-stimulated platelets, fibrinogen bound to DTT-treated platelets remained sensitive to dissociation by EDTA over a 3 h time course, retained its ability to support aggregation, even when aggregation was induced 60 min after the initial platelet exposure to fibrinogen, and remained accessible to polyclonal antibodies and plasmin. Dithiothreitol 73-76 fibrinogen beta chain Homo sapiens 53-63 7482417-7 1995 Confocal scanning laser microscopy showed only a surface clustering of fibrinogen bound to DTT-treated platelets over the 3 h time course compared to rapid fibrinogen clearing from the surface of ADP-stimulated platelets. Dithiothreitol 91-94 fibrinogen beta chain Homo sapiens 71-81