PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26373319-0 2015 Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer. Glutamine 34-43 urothelial cancer associated 1 Homo sapiens 20-24 35021150-0 2022 Long noncoding RNA UCA1 promotes glutamine-driven anaplerosis of bladder cancer by interacting with hnRNP I/L to upregulate GPT2 expression. Glutamine 33-42 urothelial cancer associated 1 Homo sapiens 19-23 35021150-5 2022 Importantly, UCA1 specifically bound to and facilitated the combination of hnRNP I/L to the promoter of glutamic pyruvate transaminase 2 (GPT2), an enzyme transferring glutamate to alpha-ketoglutarate, resulting in upregulated expression of GPT2 and enhanced glutamine-derived carbons in the TCA cycle. Glutamine 259-268 urothelial cancer associated 1 Homo sapiens 13-17 35021150-6 2022 We also systematically confirmed the influence of UCA1 and hnRNP I/L on metabolism and proliferation via glutamine-driven anaplerosis in BLCA. Glutamine 105-114 urothelial cancer associated 1 Homo sapiens 50-54 35021150-7 2022 Our study revealed the critical role of UCA1-mediated mechanisms involved in glutamine-driven anaplerosis and provided novel evidence that lncRNA regulates metabolic reprogramming in tumor cells. Glutamine 77-86 urothelial cancer associated 1 Homo sapiens 40-44 35182956-0 2022 Comment on "Long noncoding RNA UCA1 promotes glutamine-driven anaplerosis of bladder cancer by interacting with hnRNP I/L to upregulate GPT2 expression" by Chen et al."". Glutamine 45-54 urothelial cancer associated 1 Homo sapiens 31-35 35182956-5 2022 report the novel function of UCA1 in glutamine metabolism through interacting with heterogeneous nuclear ribonucleoproteins (hnRNPs) I and L (hnRNP I/L). Glutamine 37-46 urothelial cancer associated 1 Homo sapiens 29-33