PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35120924-1 2022 Sulfite oxidase (SOX) is a homodimeric molybdo-heme enzyme that oxidizes sulfite to sulfate at the molybdenum center. Sulfites 73-80 sulfite oxidase Homo sapiens 0-15 34741542-2 2022 SO is a mitochondrially localized molybdenum cofactor (Moco)- and heme-dependent enzyme, which catalyzes the vital oxidation of toxic sulfite to sulfate. Sulfites 134-141 sulfite oxidase Homo sapiens 0-2 34915296-6 2022 The catalytic mechanism of the NADH oxidase mimics is that O2 involves in the oxidation of NADH, to generate O2.- intermediate and finally turn to H2O2, while SuOx mimics comes from that MoS2 particles can effectively catalyze sulfite to reduce (Fe(CN)6)3-. Sulfites 227-234 sulfite oxidase Homo sapiens 159-163 34915296-7 2022 Based on the excellent SuOx-like activity of MoS2 particles, while phenol can inhibit the oxidation of sulfite, a phenol colorimetric sensor was explored with the dynamic range of 2-1000 muM and the limit of detection of 0.72 muM, applicable to detect phenol in effluents. Sulfites 103-110 sulfite oxidase Homo sapiens 23-27 35120924-1 2022 Sulfite oxidase (SOX) is a homodimeric molybdo-heme enzyme that oxidizes sulfite to sulfate at the molybdenum center. Sulfites 73-80 sulfite oxidase Homo sapiens 17-20 35120924-4 2022 To address whether one subunit in a SOX dimer is sufficient for catalysis, we produced heterodimeric SOX variants with abolished sulfite oxidation by replacing the molybdenum-coordinating and essential cysteine in the active site. Sulfites 129-136 sulfite oxidase Homo sapiens 101-104 4016147-9 1985 Therefore, the activity of the "sulfite-detoxifying enzyme" sulfite oxidase and the sensitivity of the energy metabolism to sulfite show a reciprocal relationship in the tissues and cells studied. Sulfites 32-39 sulfite oxidase Homo sapiens 60-75 3556020-9 1987 Sulfite metabolism and the role of sulfite oxidase in the detoxification of exogenous sulfite are reviewed in relationship to the etiology of sulfite hypersensitivity. Sulfites 86-93 sulfite oxidase Homo sapiens 35-50 4016147-0 1985 Effect of sulfite on the energy metabolism of mammalian tissues in correlation to sulfite oxidase activity. Sulfites 10-17 sulfite oxidase Homo sapiens 82-97 3657521-0 1987 Sulfite determination: sulfite oxidase. Sulfites 0-7 sulfite oxidase Homo sapiens 23-38 7219240-0 1981 Sulfite oxidase deficiency: a high risk factor in SO2, sulfite, and bisulfite toxicity? Sulfites 55-62 sulfite oxidase Homo sapiens 0-15 7219240-2 1981 Sulfite oxidase is believed to be responsible for the detoxification of SO2 and/or sulfite to sulfate for excretion. Sulfites 83-90 sulfite oxidase Homo sapiens 0-15 31583830-1 2019 Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level. Sulfites 89-96 sulfite oxidase Homo sapiens 0-15 33271457-2 2021 Sulfite oxidase is catalyzing the terminal reaction of cellular cysteine catabolism, the oxidation of sulfite to sulfate. Sulfites 102-109 sulfite oxidase Homo sapiens 0-15 32275133-6 2020 The high transient local temperature on the surface of ML-MoOx generated by the photothermal effect facilitates to impact the reaction velocity and feed the SuOx-like activity, while the generation of hot carriers which are suggested as predominant effects catalyzes the oxidation of sulfite to sulfate through significantly decreasing the activation energy for the SuOx-like reaction. Sulfites 284-291 sulfite oxidase Homo sapiens 157-161 32275133-6 2020 The high transient local temperature on the surface of ML-MoOx generated by the photothermal effect facilitates to impact the reaction velocity and feed the SuOx-like activity, while the generation of hot carriers which are suggested as predominant effects catalyzes the oxidation of sulfite to sulfate through significantly decreasing the activation energy for the SuOx-like reaction. Sulfites 284-291 sulfite oxidase Homo sapiens 366-370 31714892-11 2020 SUOX detoxifies sulfite from sulfur-containing amino acids. Sulfites 16-23 sulfite oxidase Homo sapiens 0-4 31751299-8 2020 SUOX detoxifies the sulfites. Sulfites 20-28 sulfite oxidase Homo sapiens 0-4 31583830-1 2019 Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level. Sulfites 89-96 sulfite oxidase Homo sapiens 17-21 31583830-1 2019 Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level. Sulfites 148-155 sulfite oxidase Homo sapiens 0-15 31583830-1 2019 Sulfite oxidase (SuOx ) is a molybdenum-dependent enzyme that catalyzes the oxidation of sulfite to sulfate to maintain the intracellular levels of sulfite at an appropriate low level. Sulfites 148-155 sulfite oxidase Homo sapiens 17-21 31583830-6 2019 It is found that vitamin B1 (VB1) inhibits the SuOx mimic activity of P-MoO3 -x NPs through the irreversible cleavage by sulfite and the electrostatic interaction with P-MoO3 -x NPs. Sulfites 121-128 sulfite oxidase Homo sapiens 47-51 31001109-1 2019 Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). Sulfites 0-7 sulfite oxidase Homo sapiens 96-111 31127934-1 2019 Sulfite oxidase (SO) is encoded by the nuclear SUOX gene and catalyzes the final step in cysteine catabolism thereby oxidizing sulfite to sulfate. Sulfites 127-134 sulfite oxidase Homo sapiens 0-15 31127934-1 2019 Sulfite oxidase (SO) is encoded by the nuclear SUOX gene and catalyzes the final step in cysteine catabolism thereby oxidizing sulfite to sulfate. Sulfites 127-134 sulfite oxidase Homo sapiens 17-19 31127934-1 2019 Sulfite oxidase (SO) is encoded by the nuclear SUOX gene and catalyzes the final step in cysteine catabolism thereby oxidizing sulfite to sulfate. Sulfites 127-134 sulfite oxidase Homo sapiens 47-51 31127934-2 2019 Oxidation of sulfite is dependent on two cofactors within SO, a heme and the molybdenum cofactor (Moco), the latter forming the catalytic site of sulfite oxidation. Sulfites 13-20 sulfite oxidase Homo sapiens 58-60 31002874-0 2019 Reciprocal regulation of sulfite oxidation and nitrite reduction by mitochondrial sulfite oxidase. Sulfites 25-32 sulfite oxidase Homo sapiens 82-97 31167903-4 2019 In the presence of the physiological electron acceptor cytochrome c, we were able to close the catalytic cycle of sulfite-dependent nitrite reduction thus leading to steady-state NO synthesis, a finding that strongly supports a physiological relevance of SO-dependent NO formation. Sulfites 114-121 sulfite oxidase Homo sapiens 255-257 31001109-1 2019 Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). Sulfites 0-7 sulfite oxidase Homo sapiens 113-116 28529047-1 2017 Sulfite accumulates in tissues of patients affected by sulfite oxidase (SO) deficiency, a neurometabolic disease characterized by seizures and progressive encephalopathy, often resulting in early death. Sulfites 0-7 sulfite oxidase Homo sapiens 55-70 29767695-6 2018 Sulfite oxidase, an enzyme found in mitochondria, catalyzes oxidation of sulfite to sulfate, the final step in oxidation of sulfur amino acids (cysteine and methionine). Sulfites 73-80 sulfite oxidase Homo sapiens 0-15 29549261-1 2018 Sulfite oxidase is a mononuclear molybdenum enzyme that oxidises sulfite to sulfate in many organisms, including man. Sulfites 65-72 sulfite oxidase Homo sapiens 0-15 24506486-9 2016 Sulfite is oxidized to sulfate by sulfite oxidase, this enzyme is determinant in sulfate synthesis, and it is absent in many mesophiles. Sulfites 0-7 sulfite oxidase Homo sapiens 34-49 27260448-0 2016 A sensitive and selective on-line amperometric sulfite biosensor using sulfite oxidase immobilized on a magnetite-gold-folate nanocomposite modified carbon-paste electrode. Sulfites 47-54 sulfite oxidase Homo sapiens 71-86 27260448-1 2016 We describe a novel amperometric sulfite biosensor, comprising a carbon-paste electrode (Fe3O4@Au-Cys-FA/CPE) modified with immobilized sulfite oxidase (SOx) on a gold-coated magnetite nanoparticle core, encased within a conjugated folic acid (FA) cysteine (Cys) shell. Sulfites 33-40 sulfite oxidase Homo sapiens 136-151 27260448-1 2016 We describe a novel amperometric sulfite biosensor, comprising a carbon-paste electrode (Fe3O4@Au-Cys-FA/CPE) modified with immobilized sulfite oxidase (SOx) on a gold-coated magnetite nanoparticle core, encased within a conjugated folic acid (FA) cysteine (Cys) shell. Sulfites 33-40 sulfite oxidase Homo sapiens 153-156 28735401-0 2017 Determination of Enzymes Associated with Sulfite Toxicity in Plants: Kinetic Assays for SO, APR, SiR, and In-Gel SiR Activity. Sulfites 41-48 sulfite oxidase Homo sapiens 88-90 28735401-3 2017 Cysteine is generated by the sulfate reductive pathway where sulfite oxidase (SO; EC 1.8.3.1) is an important enzyme in the homeostasis of sulfite levels (present either as a toxic intermediate in the pathway or as a toxic air pollutant that has penetrated the plant tissue via the stomata). Sulfites 61-68 sulfite oxidase Homo sapiens 78-80 28735401-4 2017 SO is localized to the peroxisomes and detoxifies excess sulfite by catalyzing its oxidation to sulfate. Sulfites 57-64 sulfite oxidase Homo sapiens 0-2 27692161-5 2016 Sulfite oxidase, a molybdenum-containing enzyme, catalyzes oxidation of sulfite to sulfate, which can then be excreted or reused by the body. Sulfites 72-79 sulfite oxidase Homo sapiens 0-15 25372012-7 2014 Likewise, all three models can catalyze the oxidation of sulfite, provided that the Coulombic repulsion between the substrate and the enzyme model can be overcome, but for this harder reaction, the SO model gives the lowest activation barrier, although the differences are not large. Sulfites 57-64 sulfite oxidase Homo sapiens 198-200 26171830-1 2015 Mammalian sulfite oxidase (SO) is a dimeric enzyme consisting of a molybdenum cofactor- (Moco) and haem-containing domain and catalyses the oxidation of toxic sulfite to sulfate. Sulfites 10-17 sulfite oxidase Homo sapiens 27-29 24702461-1 2014 Sulfite oxidase is a mitochondria-located molybdenum-containing enzyme catalyzing the oxidation of sulfite to sulfate in the amino acid and lipid metabolism. Sulfites 99-106 sulfite oxidase Homo sapiens 0-15 24957901-1 2014 The oxidation of sulfite to sulfate by two different models of the active site of sulfite oxidase has been studied. Sulfites 17-24 sulfite oxidase Homo sapiens 82-97 24793416-1 2014 Sulfite oxidase (SO) deficiency is biochemically characterized by the accumulation of sulfite, thiosulfate and S-sulfocysteine in tissues and biological fluids of the affected patients. Sulfites 86-93 sulfite oxidase Homo sapiens 0-15 24793416-1 2014 Sulfite oxidase (SO) deficiency is biochemically characterized by the accumulation of sulfite, thiosulfate and S-sulfocysteine in tissues and biological fluids of the affected patients. Sulfites 86-93 sulfite oxidase Homo sapiens 17-19 24147957-1 2013 Sulfite oxidase (SO) is an essential molybdoenzyme for humans, catalyzing the final step in the degradation of sulfur-containing amino acids and lipids, which is the oxidation of sulfite to sulfate. Sulfites 179-186 sulfite oxidase Homo sapiens 0-15 23392406-3 2013 Sulfite biosensors are based on measurement of either O2 or electrons generated from splitting of H2O2 or heat released during oxidation of sulfite by immobilized sulfite oxidase. Sulfites 0-7 sulfite oxidase Homo sapiens 163-178 23779234-1 2013 Sulfite oxidase (SO) is a vital metabolic enzyme that catalyzes the oxidation of toxic sulfite to sulfate. Sulfites 87-94 sulfite oxidase Homo sapiens 0-15 23779234-1 2013 Sulfite oxidase (SO) is a vital metabolic enzyme that catalyzes the oxidation of toxic sulfite to sulfate. Sulfites 87-94 sulfite oxidase Homo sapiens 17-19 23392406-3 2013 Sulfite biosensors are based on measurement of either O2 or electrons generated from splitting of H2O2 or heat released during oxidation of sulfite by immobilized sulfite oxidase. Sulfites 140-147 sulfite oxidase Homo sapiens 163-178 22854042-1 2012 Sulfite oxidase (SO) catalyses the metabolic detoxification of sulfite to sulfate within the intermembrane space of mitochondria. Sulfites 63-70 sulfite oxidase Homo sapiens 0-15 23440026-1 2013 Sulfite oxidizing enzymes (SOEs), including sulfite oxidase (SO) and bacterial sulfite dehydrogenase (SDH), catalyze the oxidation of sulfite (SO(3) (2-)) to sulfate (SO(4) (2-)). Sulfites 44-51 sulfite oxidase Homo sapiens 27-29 23440026-1 2013 Sulfite oxidizing enzymes (SOEs), including sulfite oxidase (SO) and bacterial sulfite dehydrogenase (SDH), catalyze the oxidation of sulfite (SO(3) (2-)) to sulfate (SO(4) (2-)). Sulfites 44-51 sulfite oxidase Homo sapiens 61-63 22854042-1 2012 Sulfite oxidase (SO) catalyses the metabolic detoxification of sulfite to sulfate within the intermembrane space of mitochondria. Sulfites 63-70 sulfite oxidase Homo sapiens 17-19 22209453-1 2012 The present study reports a facile approach for sulfite biosensing, based on enhanced direct electron transfer of a human sulfite oxidase (hSO) immobilized on a gold nanoparticles modified electrode. Sulfites 48-55 sulfite oxidase Homo sapiens 122-137 21072368-1 2010 Sulfite oxidase (SO) is a molybdenum-cofactor-dependent enzyme that catalyzes the oxidation of sulfite to sulfate, the final step in the catabolism of the sulfur-containing amino acids, cysteine and methionine. Sulfites 95-102 sulfite oxidase Homo sapiens 0-15 21072368-1 2010 Sulfite oxidase (SO) is a molybdenum-cofactor-dependent enzyme that catalyzes the oxidation of sulfite to sulfate, the final step in the catabolism of the sulfur-containing amino acids, cysteine and methionine. Sulfites 95-102 sulfite oxidase Homo sapiens 17-19 19793632-1 2010 Sulfite oxidase is a mitochondrial enzyme encoded by the SUOX gene and essential for the detoxification of sulfite which results mainly from the catabolism of sulfur-containing amino acids. Sulfites 107-114 sulfite oxidase Homo sapiens 0-15 20666399-3 2010 In animals, SO catalyzes the oxidation of toxic sulfite to sulfate as the final step in the catabolism of the sulfur-containing amino acids, methionine and cysteine. Sulfites 48-55 sulfite oxidase Homo sapiens 12-14 19793632-1 2010 Sulfite oxidase is a mitochondrial enzyme encoded by the SUOX gene and essential for the detoxification of sulfite which results mainly from the catabolism of sulfur-containing amino acids. Sulfites 107-114 sulfite oxidase Homo sapiens 57-61 19140755-1 2009 We present a density functional theory (DFT) study on the conversion of sulfite to sulfate with a model complex representing the active site of the molybdenum-containing enzyme sulfite oxidase (SO). Sulfites 72-79 sulfite oxidase Homo sapiens 177-192 20063894-1 2010 Sulfite oxidase (SO) is a vitally important molybdenum enzyme that catalyzes the oxidation of toxic sulfite to sulfate. Sulfites 100-107 sulfite oxidase Homo sapiens 0-15 20063894-1 2010 Sulfite oxidase (SO) is a vitally important molybdenum enzyme that catalyzes the oxidation of toxic sulfite to sulfate. Sulfites 100-107 sulfite oxidase Homo sapiens 17-19 19140755-1 2009 We present a density functional theory (DFT) study on the conversion of sulfite to sulfate with a model complex representing the active site of the molybdenum-containing enzyme sulfite oxidase (SO). Sulfites 72-79 sulfite oxidase Homo sapiens 194-196 16858610-2 2006 Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate. Sulfites 128-135 sulfite oxidase Homo sapiens 0-15 16858610-2 2006 Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate. Sulfites 128-135 sulfite oxidase Homo sapiens 17-20 16858610-2 2006 Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate. Sulfites 161-168 sulfite oxidase Homo sapiens 0-15 16858610-2 2006 Sulfite oxidase (SOX), a heme- and molybdenum containing mitochondrial enzyme, prevents mammalian cells from adverse effects of sulfite toxicity by metabolizing sulfite to sulfate. Sulfites 161-168 sulfite oxidase Homo sapiens 17-20 14729666-9 2004 These results demonstrate that the Tyr(343) residue is important for both substrate binding and oxidation of sulfite by sulfite oxidase. Sulfites 109-116 sulfite oxidase Homo sapiens 120-135 16234925-1 2005 The physiologically essential oxidation of sulfite to sulfate is catalyzed by the molybdoheme enzyme, sulfite oxidase. Sulfites 43-50 sulfite oxidase Homo sapiens 102-117 17723349-0 2006 Determination of sulfite in beer samples using an amperometric fill and flow channel biosensor employing sulfite oxidase. Sulfites 17-24 sulfite oxidase Homo sapiens 105-120 17723349-8 2006 The enzyme layer contains sulfite oxidase, which, in the process of oxidizing sulfite, produces hydrogen peroxide, which itself is reduced by excess sulfite. Sulfites 78-85 sulfite oxidase Homo sapiens 26-41 14567685-2 2003 Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc. Sulfites 111-118 sulfite oxidase Homo sapiens 57-59 14567685-2 2003 Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc. Sulfites 111-118 sulfite oxidase Homo sapiens 178-180 14567685-2 2003 Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc. Sulfites 231-238 sulfite oxidase Homo sapiens 57-59 14567685-2 2003 Previous steady-state kinetic studies of the R160Q human SO mutant showed a remarkable decrease in k(cat)/K(m)(sulfite) of nearly 1000-fold, which suggests that Arg 160 in human SO makes an important contribution to the binding of sulfite near the molybdenum cofactor [Garrett, R. M., Johnson, J. L., Graf, T. N., Feigenbaum, A., Rajagopalan, K. V. (1998) Proc. Sulfites 231-238 sulfite oxidase Homo sapiens 178-180 14567685-7 2003 In the crystal structure of chicken SO, Arg 138, the equivalent of Arg 160 in human SO, is involved in the formation of a positively charged sulfite binding site [Kisker, C., Schindelin, H., Pacheco, A., Wehbi, W., Garnett, R. M., Rajagopalan, K. V., Enemark, J. H., Rees, D. C. (1997) Cell 91, 973-983]. Sulfites 141-148 sulfite oxidase Homo sapiens 36-38 14514920-2 2003 Sulfate for conjugation is produced primarily from the oxidation of cysteine, begun by cysteine dioxygenase (CDO), and completed with the conversion of sulfite to sulfate via sulfite oxidase (SO). Sulfites 152-159 sulfite oxidase Homo sapiens 175-190 14514920-2 2003 Sulfate for conjugation is produced primarily from the oxidation of cysteine, begun by cysteine dioxygenase (CDO), and completed with the conversion of sulfite to sulfate via sulfite oxidase (SO). Sulfites 152-159 sulfite oxidase Homo sapiens 192-194 12269282-2 2001 pH dependent reactivity differences of dimethylsulfite towards the title complex 1 demonstrate the crucial need of oxo-anionic coordination of sulfite to the molybdenum centre of 1 in the model reductive half reaction of sulfite oxidase. Sulfites 47-54 sulfite oxidase Homo sapiens 221-236