PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33640406-2	2021	CHT1-medated choline uptake is specifically inhibited by hemicholinium-3, which is a type of choline analog that acts as a competitive inhibitor.	Hemicholinium 3	57-72	solute carrier family 5 member 7	Homo sapiens	0-4	
33640406-3	2021	Although the substrate choline and the inhibitor hemicholinium-3 are well-established ligands of CHT 1, few potent ligands other than choline analogs have been reported.	Hemicholinium 3	49-64	solute carrier family 5 member 7	Homo sapiens	97-102	
33640406-6	2021	We found that morantel as well as other tetrahydropyrimidines, pyrantel and oxantel, potently inhibits the high-affinity choline uptake activity of CHT 1 in a competitive manner similar to the inhibitor hemicholinium-3.	Hemicholinium 3	203-218	solute carrier family 5 member 7	Homo sapiens	148-153	
28577989-0	2017	Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity.	Hemicholinium 3	0-15	solute carrier family 5 member 7	Homo sapiens	106-125	
28577989-0	2017	Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity.	Hemicholinium 3	0-15	solute carrier family 5 member 7	Homo sapiens	127-130	
27288078-3	2016	In retrospect, the molecular era of CHT studies initiated with the identification of hemicholinium-3 (HC-3), a potent, competitive CHT antagonist, though it would take another 30 years before HC-3, in radiolabeled form, was used by Joseph Coyle"s laboratory to identify and monitor the dynamics of CHT proteins.	Hemicholinium 3	85-100	solute carrier family 5 member 7	Homo sapiens	36-39	
27288078-3	2016	In retrospect, the molecular era of CHT studies initiated with the identification of hemicholinium-3 (HC-3), a potent, competitive CHT antagonist, though it would take another 30 years before HC-3, in radiolabeled form, was used by Joseph Coyle"s laboratory to identify and monitor the dynamics of CHT proteins.	Hemicholinium 3	85-100	solute carrier family 5 member 7	Homo sapiens	131-134	
27288078-3	2016	In retrospect, the molecular era of CHT studies initiated with the identification of hemicholinium-3 (HC-3), a potent, competitive CHT antagonist, though it would take another 30 years before HC-3, in radiolabeled form, was used by Joseph Coyle"s laboratory to identify and monitor the dynamics of CHT proteins.	Hemicholinium 3	85-100	solute carrier family 5 member 7	Homo sapiens	131-134	
23077721-6	2012	We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators.	Hemicholinium 3	164-179	solute carrier family 5 member 7	Homo sapiens	260-263	
23077721-6	2012	We established that the addition of choline to these cells, at concentrations appropriate for high-affinity choline transport at presynaptic terminals, generates a hemicholinium-3 (HC-3)-sensitive, membrane depolarization that can be used for the screening of CHT inhibitors and activators.	Hemicholinium 3	181-186	solute carrier family 5 member 7	Homo sapiens	260-263	
22016532-6	2011	Specific inhibitor hemicholinium-3 decreases the constitutive internalization rate and thereby increases cell-surface CHT1 expression.	Hemicholinium 3	19-34	solute carrier family 5 member 7	Homo sapiens	118-122	
15090548-1	2004	CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter.	Hemicholinium 3	38-53	solute carrier family 5 member 7	Homo sapiens	0-4	
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	28-43	solute carrier family 5 member 7	Homo sapiens	4-8	
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	28-43	solute carrier family 5 member 7	Homo sapiens	184-188	
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	45-49	solute carrier family 5 member 7	Homo sapiens	4-8	
17005849-5	2006	The hCHT-specific inhibitor hemicholinium-3 (HC-3) blocks choline uptake and choline-induced current; in addition, HC-3 alone reveals a constitutive, depolarizing leak current through hCHT.	Hemicholinium 3	45-49	solute carrier family 5 member 7	Homo sapiens	184-188	
15090548-1	2004	CHT1 is a Na(+)- and Cl(-)-dependent, hemicholinium-3 (HC-3)-sensitive, high affinity choline transporter.	Hemicholinium 3	55-60	solute carrier family 5 member 7	Homo sapiens	0-4	
15090548-4	2004	Transfection of neural IMR-32 cells with human CHT1 conferred Na(+)-dependent, HC-3-sensitive choline uptake that was effectively inhibited by cotransfection of Par-4.	Hemicholinium 3	79-83	solute carrier family 5 member 7	Homo sapiens	47-51	
12628469-6	2003	Consistent with that finding, specific binding of [3H]hemicholinium-3 (HC-3), an inhibitor of CHT1, and HC-3-sensitive [3H]choline uptake were also detected in MOLT-3 cells.	Hemicholinium 3	54-69	solute carrier family 5 member 7	Homo sapiens	94-98	
12675135-6	2003	CHT1 mediates Na(+)- and Cl(-)-dependent choline uptake with high sensitivity to hemicholinium-3.	Hemicholinium 3	81-96	solute carrier family 5 member 7	Homo sapiens	0-4