PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31581160-1 2019 BACKGROUND Serine hydroxymethyltransferase (SHMT) is the enzyme that catalyzes the reversible conversion of serine to glycine and tetrahydrofolate-bound one-carbon unit. 5,6,7,8-tetrahydrofolic acid 130-146 serine hydroxymethyltransferase 1 Homo sapiens 11-42 6776288-2 1980 Serine hydroxmethyltransferase (SHMT: L-serine: tetrahydrofolate 5, 10-hydroxymethyltransferase, EC 2.12.1) was assayed radiometrically in whole cell homogenates, crude supernatant fractions and crude particulate fractions. 5,6,7,8-tetrahydrofolic acid 48-64 serine hydroxymethyltransferase 1 Homo sapiens 32-36 31581160-1 2019 BACKGROUND Serine hydroxymethyltransferase (SHMT) is the enzyme that catalyzes the reversible conversion of serine to glycine and tetrahydrofolate-bound one-carbon unit. 5,6,7,8-tetrahydrofolic acid 130-146 serine hydroxymethyltransferase 1 Homo sapiens 44-48 30522268-1 2019 Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 142-158 serine hydroxymethyltransferase 1 Homo sapiens 0-31 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). 5,6,7,8-tetrahydrofolic acid 77-80 serine hydroxymethyltransferase 1 Homo sapiens 312-343 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). 5,6,7,8-tetrahydrofolic acid 77-80 serine hydroxymethyltransferase 1 Homo sapiens 345-349 30522268-1 2019 Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 142-158 serine hydroxymethyltransferase 1 Homo sapiens 33-37 30522268-1 2019 Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 160-163 serine hydroxymethyltransferase 1 Homo sapiens 0-31 30522268-1 2019 Serine hydroxymethyltransferase (SHMT) is a pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 160-163 serine hydroxymethyltransferase 1 Homo sapiens 33-37 29991441-1 2018 Serine hydroxymethyltransferase (SHMT) is a pivotal enzyme in one-carbon metabolism that catalyses the reversible conversion of serine and tetrahydrofolate into glycine and methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 139-155 serine hydroxymethyltransferase 1 Homo sapiens 0-31 30500180-1 2018 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible conversion of l-serine and tetrahydrofolate into glycine and 5,10-methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 91-107 serine hydroxymethyltransferase 1 Homo sapiens 0-31 30500180-1 2018 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible conversion of l-serine and tetrahydrofolate into glycine and 5,10-methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 91-107 serine hydroxymethyltransferase 1 Homo sapiens 33-37 29991441-1 2018 Serine hydroxymethyltransferase (SHMT) is a pivotal enzyme in one-carbon metabolism that catalyses the reversible conversion of serine and tetrahydrofolate into glycine and methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 139-155 serine hydroxymethyltransferase 1 Homo sapiens 33-37 12514178-1 2003 Cytoplasmic serine hydroxymethyltransferase (cSHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 172-188 serine hydroxymethyltransferase 1 Homo sapiens 0-43 30035852-2 2018 Depending on cell demands, serine hydroxymethyltransferase (SHMT) dynamically changes the fluxes of OCM by reversibly converting serine and tetrahydrofolate (THF) into 5,10-methylene-THF and glycine. 5,6,7,8-tetrahydrofolic acid 140-156 serine hydroxymethyltransferase 1 Homo sapiens 27-58 30035852-2 2018 Depending on cell demands, serine hydroxymethyltransferase (SHMT) dynamically changes the fluxes of OCM by reversibly converting serine and tetrahydrofolate (THF) into 5,10-methylene-THF and glycine. 5,6,7,8-tetrahydrofolic acid 140-156 serine hydroxymethyltransferase 1 Homo sapiens 60-64 30035852-2 2018 Depending on cell demands, serine hydroxymethyltransferase (SHMT) dynamically changes the fluxes of OCM by reversibly converting serine and tetrahydrofolate (THF) into 5,10-methylene-THF and glycine. 5,6,7,8-tetrahydrofolic acid 158-161 serine hydroxymethyltransferase 1 Homo sapiens 27-58 30035852-2 2018 Depending on cell demands, serine hydroxymethyltransferase (SHMT) dynamically changes the fluxes of OCM by reversibly converting serine and tetrahydrofolate (THF) into 5,10-methylene-THF and glycine. 5,6,7,8-tetrahydrofolic acid 158-161 serine hydroxymethyltransferase 1 Homo sapiens 60-64 29073064-1 2017 The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. 5,6,7,8-tetrahydrofolic acid 84-100 serine hydroxymethyltransferase 1 Homo sapiens 11-41 29073064-1 2017 The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. 5,6,7,8-tetrahydrofolic acid 84-100 serine hydroxymethyltransferase 1 Homo sapiens 43-47 28760597-1 2017 Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis. 5,6,7,8-tetrahydrofolic acid 143-159 serine hydroxymethyltransferase 1 Homo sapiens 0-31 28760597-1 2017 Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis. 5,6,7,8-tetrahydrofolic acid 143-159 serine hydroxymethyltransferase 1 Homo sapiens 33-37 28760597-1 2017 Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis. 5,6,7,8-tetrahydrofolic acid 161-164 serine hydroxymethyltransferase 1 Homo sapiens 0-31 28760597-1 2017 Serine hydroxymethyltransferase (SHMT), an essential enzyme for cell growth and development, catalyzes the transfer of -CH2OH from l-serine to tetrahydrofolate (THF) to form glycine and 5,10-methylenetetrahydrofolate (MTHF) which is used for nucleotide synthesis. 5,6,7,8-tetrahydrofolic acid 161-164 serine hydroxymethyltransferase 1 Homo sapiens 33-37 24698160-1 2014 UNLABELLED: Serine hydroxymethyltransferase (SHMT) catalyzes the transfer of a hydroxymethyl group from l-serine to tetrahydrofolate to yield glycine and 5,10-methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 116-132 serine hydroxymethyltransferase 1 Homo sapiens 45-49 15170323-1 2004 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier. 5,6,7,8-tetrahydrofolic acid 107-123 serine hydroxymethyltransferase 1 Homo sapiens 0-31 15170323-1 2004 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate serving as the one-carbon carrier. 5,6,7,8-tetrahydrofolic acid 107-123 serine hydroxymethyltransferase 1 Homo sapiens 33-37 25677305-2 2015 Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs. 5,6,7,8-tetrahydrofolic acid 103-119 serine hydroxymethyltransferase 1 Homo sapiens 0-31 25677305-2 2015 Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs. 5,6,7,8-tetrahydrofolic acid 103-119 serine hydroxymethyltransferase 1 Homo sapiens 33-37 22220685-1 2012 Serine hydroxymethyltransferase (SHMT) catalyzes the transfer of a beta-carbon from serine to tetrahydrofolate to form glycine and 5,10-methylene-tetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 94-110 serine hydroxymethyltransferase 1 Homo sapiens 0-31 22220685-1 2012 Serine hydroxymethyltransferase (SHMT) catalyzes the transfer of a beta-carbon from serine to tetrahydrofolate to form glycine and 5,10-methylene-tetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 94-110 serine hydroxymethyltransferase 1 Homo sapiens 33-37 21371789-1 2011 Serine hydroxymethyltransferase (SHMT), a ubiquitous representative of the family of fold-type I, pyridoxal 5"-phosphate (PLP) dependent enzymes, catalyzes the reversible conversion of tetrahydrofolate (H4PteGlu) and serine to 5,10-CH2-H4PteGlu and glycine. 5,6,7,8-tetrahydrofolic acid 185-201 serine hydroxymethyltransferase 1 Homo sapiens 0-31 21371789-1 2011 Serine hydroxymethyltransferase (SHMT), a ubiquitous representative of the family of fold-type I, pyridoxal 5"-phosphate (PLP) dependent enzymes, catalyzes the reversible conversion of tetrahydrofolate (H4PteGlu) and serine to 5,10-CH2-H4PteGlu and glycine. 5,6,7,8-tetrahydrofolic acid 185-201 serine hydroxymethyltransferase 1 Homo sapiens 33-37 16980404-1 2006 Serine hydroxymethyl transferase (SHMT) is a pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 143-159 serine hydroxymethyltransferase 1 Homo sapiens 0-32 16980404-1 2006 Serine hydroxymethyl transferase (SHMT) is a pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 143-159 serine hydroxymethyltransferase 1 Homo sapiens 34-38 12514178-1 2003 Cytoplasmic serine hydroxymethyltransferase (cSHMT) is a tetrameric, pyridoxal phosphate (PLP)-dependent enzyme that catalyzes the reversible interconversion of serine and tetrahydrofolate to glycine and methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 172-188 serine hydroxymethyltransferase 1 Homo sapiens 45-50 8786078-1 1996 The conversion of serine and tetrahydrofolate to glycine and 5,10 methylene tetrahydrofolate by serine hydroxymethyltransferase (SHMT, EC 2.1.2.1) is the major route for the provision of one-carbon units for biosynthetic reactions. 5,6,7,8-tetrahydrofolic acid 29-45 serine hydroxymethyltransferase 1 Homo sapiens 96-127 9753690-2 1998 As an enzyme of the thymidylate synthase metabolic cycle, SHMT catalyses the retro-aldol cleavage of serine to glycine, with the resulting hydroxymethyl group being transferred to tetrahydrofolate to form 5, 10-methylene-tetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 180-196 serine hydroxymethyltransferase 1 Homo sapiens 58-62 15044825-5 2003 Serine hydroxymethyltransferase (SHMT) is a member of this alpha-class; it reversibly catalyses the conversion of serine into glycine while the hydroxymethyl group is transferred to 5,6,7,8-tetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 182-206 serine hydroxymethyltransferase 1 Homo sapiens 0-31 15044825-5 2003 Serine hydroxymethyltransferase (SHMT) is a member of this alpha-class; it reversibly catalyses the conversion of serine into glycine while the hydroxymethyl group is transferred to 5,6,7,8-tetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 182-206 serine hydroxymethyltransferase 1 Homo sapiens 33-37 11386852-4 2001 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible reaction of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 87-103 serine hydroxymethyltransferase 1 Homo sapiens 0-31 11386852-4 2001 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible reaction of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 87-103 serine hydroxymethyltransferase 1 Homo sapiens 33-37 11386852-4 2001 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible reaction of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 105-108 serine hydroxymethyltransferase 1 Homo sapiens 0-31 11386852-4 2001 Serine hydroxymethyltransferase (SHMT) catalyzes the reversible reaction of serine and tetrahydrofolate (THF) to glycine and 5,10-methylene THF. 5,6,7,8-tetrahydrofolic acid 105-108 serine hydroxymethyltransferase 1 Homo sapiens 33-37 8786078-1 1996 The conversion of serine and tetrahydrofolate to glycine and 5,10 methylene tetrahydrofolate by serine hydroxymethyltransferase (SHMT, EC 2.1.2.1) is the major route for the provision of one-carbon units for biosynthetic reactions. 5,6,7,8-tetrahydrofolic acid 29-45 serine hydroxymethyltransferase 1 Homo sapiens 129-133 1532227-1 1992 Serine hydroxymethyltransferase (SHMT) occupies a central position in one-carbon (C1) metabolism, catalyzing the reaction of serine and tetrahydrofolate to yield glycine and 5,10-methylenetetrahydrofolate. 5,6,7,8-tetrahydrofolic acid 136-152 serine hydroxymethyltransferase 1 Homo sapiens 33-37