PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18086667-1	2008	R67 dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate using NADPH as a cofactor.	dihydrofolate	4-17	dihydrofolate reductase	Escherichia coli	29-33	
31289693-2	2019	Dihydrofolate Reductase from Thermotoga maritima (TmDFHFR) is a dimeric thermophilic enzyme that catalyzes the hydride transfer from the cofactor NADPH to dihydrofolate less efficiently than other DHFR enzymes, such as the mesophilic analogue Escherichia coli DHFR (EcDHFR).	dihydrofolate	155-168	dihydrofolate reductase	Escherichia coli	197-201	
31289693-2	2019	Dihydrofolate Reductase from Thermotoga maritima (TmDFHFR) is a dimeric thermophilic enzyme that catalyzes the hydride transfer from the cofactor NADPH to dihydrofolate less efficiently than other DHFR enzymes, such as the mesophilic analogue Escherichia coli DHFR (EcDHFR).	dihydrofolate	155-168	dihydrofolate reductase	Escherichia coli	260-264	
31666629-6	2019	We showed that MMV675968 targeted A. baumannii dihydrofolate reductase (AbDHFR) as determined by an E. coli surrogate whose growth was dependent on AbDHFR function and by an in vitro DHFR activity assay.	dihydrofolate	47-60	dihydrofolate reductase	Escherichia coli	74-78	
15858267-3	2005	Despite exhaustive investigation of the catalytic mechanism of DHFR, controversy persists over the exact pathway associated with proton donation in reduction of the substrate, dihydrofolate.	dihydrofolate	176-189	dihydrofolate reductase	Escherichia coli	63-67	
16873119-1	2006	Dihydrofolate reductase (DHFR) maintains the intracellular pool of tetrahydrofolate through catalysis of hydrogen transfer from reduced nicotinamide adenine dinucleotide to 7,8-dihydrofolate.	dihydrofolate	173-190	dihydrofolate reductase	Escherichia coli	25-29	
9056490-6	1997	The steady-state kinetic parameters, dissociation constants for binary complexes of dihydrofolate, NADPH, and methotrexate with ch-DHFR, and the inhibitor constant of methotrexate have also been determined.	dihydrofolate	84-97	dihydrofolate reductase	Escherichia coli	131-135	
11679579-1	2001	R67 is a Type II dihydrofolate reductase (DHFR) that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate by facilitating the addition of a proton to N5 of DHF and the transfer of a hydride ion from NADPH to C6.	dihydrofolate	17-30	dihydrofolate reductase	Escherichia coli	42-46	
11679579-1	2001	R67 is a Type II dihydrofolate reductase (DHFR) that catalyzes the reduction of dihydrofolate (DHF) to tetrahydrofolate by facilitating the addition of a proton to N5 of DHF and the transfer of a hydride ion from NADPH to C6.	dihydrofolate	95-98	dihydrofolate reductase	Escherichia coli	42-46	
11679579-3	2001	Here, Raman difference measurements, conducted on the ternary complex of R67.NADP(+).DHF believed to be an accurate mimic of the productive DHFR.NADPH.DHF complex, show that the pK(a) of N5 in the complex is less than 4.	dihydrofolate	85-88	dihydrofolate reductase	Escherichia coli	140-144