PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31801705-9	2019	Combined treatment of the cells with 3-bromopyruvate and miR-205-5p-inhibitor transfection obviously increased nuclear fragmentation and nuclear pyknosis and significantly increased cell apoptotic rate as compared with the two treatments alone (P < 0.01), causing also decreased expressions of Bcl-2 and Mcl-1 proteins and increased expressions of Bax and Bak proteins.	bromopyruvate	37-52	BCL2 apoptosis regulator	Homo sapiens	294-299	
31491344-6	2019	At a cellular mechanistic level, the present study showed that 3-BP sensitized human colon cancer cells to TRAIL-induced apoptosis via reactive oxygen species generation, upregulation of Bax, downregulation of Bcl-2 and survivin, release of cytochrome c into the cytosol, and activation of caspase-3.	bromopyruvate	63-67	BCL2 apoptosis regulator	Homo sapiens	210-215	
31801705-10	2019	CONCLUSIONS: Inhibition of miR-205-5p enhances the proapototic effect of 3-bromopyruvate in CNE2Z cells possibly in relation to the down-regulation of Mcl-1 and Bcl-2 and the up-regulation of Bak and Bax proteins.	bromopyruvate	73-88	BCL2 apoptosis regulator	Homo sapiens	161-166	
26373689-0	2016	AMP-activated protein kinase couples 3-bromopyruvate-induced energy depletion to apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins.	bromopyruvate	37-52	BCL2 apoptosis regulator	Homo sapiens	149-154	
30132536-7	2018	The expression of Bax (in MCF-7 cells) and caspase-3 (in MDA-MB-231 cells) increased following co-treatment with 3-BP and TRAIL, whereas the expression of the anti-apoptotic protein Bcl-2 decreased.	bromopyruvate	113-117	BCL2 apoptosis regulator	Homo sapiens	182-187	
26708213-7	2016	Furthermore, 3-BrPA and SCT upregulated the expression of pro-apoptotic proteins (Bax, cytochrome c, and cleaved caspase-3) and downregulated the expression of anti-apoptotic proteins (Bcl-2 and survivin).	bromopyruvate	13-19	BCL2 apoptosis regulator	Homo sapiens	185-190	
19719971-12	2009	Furthermore, 3-BrPA stimulation decreased the expressions of Bcl-2, c-Myc and mutant p53, which were strongly associated with the programmed cell death signal transduction pathway.	bromopyruvate	13-19	BCL2 apoptosis regulator	Homo sapiens	61-66	
19719971-13	2009	CONCLUSION: 3-BrPA inhibits proliferation, induces S phase and G2/M phase arrest, and promotes apoptosis in MCF-7 cells, which processes might be mediated by the downregulation of the expressions of Bcl-2, c-Myc and mutant p53.	bromopyruvate	12-18	BCL2 apoptosis regulator	Homo sapiens	199-204