PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14622907-0 2003 Transforming growth factor-alpha changes firing properties of developing neocortical GABAergic neurons by down-regulation of voltage-gated potassium currents. Potassium 139-148 tumor necrosis factor Homo sapiens 0-32 31453296-6 2019 In T1D patients, we show that secretion of cytokines IL-1beta, TNFalpha, IL-6 and IFNalpha after microbial DNA stimulation is promoted by potassium efflux and is not dependent on P2X7 receptor signaling. Potassium 138-147 tumor necrosis factor Homo sapiens 63-71 28632755-7 2017 To confirm its importance we performed a series of in vitro experiments, in which we demonstrated that potassium levels a increased the virulence of the oral community as a whole and at the same time altering the immune response of gingival epithelium, increasing the production of TNF-alpha and reducing the expression of IL-6 and the antimicrobial peptide human beta-defensin 3 (hBD-3). Potassium 103-112 tumor necrosis factor Homo sapiens 282-291 18293202-5 2008 Similarly, in vessels constricted with a high potassium solution (60 mM), which inhibits vasodilatation via endothelial-derived hyperpolarising factor (EDHF), TNF-alpha incubation also attenuated bradykinin-induced vasodilatation. Potassium 46-55 tumor necrosis factor Homo sapiens 159-168 18029910-5 2007 Similarly, lowering of extracellular potassium concentration inhibited TNF-alpha-induced TF protein expression. Potassium 37-46 tumor necrosis factor Homo sapiens 71-80 11146066-0 2001 Inhibition of astrocyte TNFalpha expression by extracellular potassium. Potassium 61-70 tumor necrosis factor Homo sapiens 24-32 11245689-0 2001 Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-(alpha) rescues axotomized retinal ganglion cells from retrograde cell death in vivo. Potassium 13-22 tumor necrosis factor Homo sapiens 99-127 11245689-3 2001 In accordance with our previous findings, TNF-alpha decreased outward potassium currents in RGCs. Potassium 70-79 tumor necrosis factor Homo sapiens 42-51 11245689-4 2001 Antagonism of the TNF-alpha-induced decrease in outward potassium currents with the potassium channel opener minoxidilsulfate (as verified by electrophysiology) abolished neuroprotection. Potassium 56-65 tumor necrosis factor Homo sapiens 18-27 11782970-8 2002 Furthermore, levels of TNF significantly increased in the supernatants of both neuron cultures after potassium-induced depolarization. Potassium 101-110 tumor necrosis factor Homo sapiens 23-26 11782970-11 2002 Potassium-induced depolarization resulted in the release of TNF in hippocampal neuron cultures within 15 min but not until 24 hr in SH-SY5Y cultures demonstrating a temporally mediated event dependent upon cell type. Potassium 0-9 tumor necrosis factor Homo sapiens 60-63 11377135-2 2001 Therefore, the glucose-insulin-potassium regimen might be beneficial in acute myocardial infarction and useful in the management of patients with septicemia, septic shock, and other inflammatory diseases in which tumor necrosis factor-alpha and macrophage migration-inhibitory factor have important roles. Potassium 31-40 tumor necrosis factor Homo sapiens 213-240 10693867-8 2000 The correlation between TNFalpha and Ag KS was positive in RA and negative in OA. Potassium 40-42 tumor necrosis factor Homo sapiens 24-32 10843757-0 2000 A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines. Potassium 11-20 tumor necrosis factor Homo sapiens 24-27 10843757-2 2000 A reduction of intracellular potassium with nigericin or valinomycin (ionophores), or ouabain (Na(+)/K(+)-ATPase inhibitor) sensitized PC60 R55/R75 cells to TNF-induced apoptosis. Potassium 29-38 tumor necrosis factor Homo sapiens 157-160 10843757-5 2000 These results suggest a role for intracellular potassium in TNF-induced apoptosis and gene induction. Potassium 47-56 tumor necrosis factor Homo sapiens 60-63 11204450-8 2000 Transforming growth factor beta (TGFbeta), polyunsaturated fatty acids and the glucose-insulin-potassium regimen can antagonize the harmful actions of TNFalpha and protect the myocardium. Potassium 95-104 tumor necrosis factor Homo sapiens 151-159 9518260-12 1998 Our data, which show that a perturbation in their cellular thiol redox status accentuates AIDS-KS cellular responsiveness to TNF-alpha, suggest a biochemical rationale for the recognized TNF-alpha AIDS-KS clinical correlation. Potassium 95-97 tumor necrosis factor Homo sapiens 125-134 9518260-9 1998 In contrast, following TNF-alpha challenge, the AIDS-KS and KS donor nonlesional cells showed a 11.89- and 5.86-fold respective increase in MnSOD activity, while the normal fibroblasts demonstrated a 1.35-fold decrease. Potassium 53-55 tumor necrosis factor Homo sapiens 23-32 9518260-12 1998 Our data, which show that a perturbation in their cellular thiol redox status accentuates AIDS-KS cellular responsiveness to TNF-alpha, suggest a biochemical rationale for the recognized TNF-alpha AIDS-KS clinical correlation. Potassium 95-97 tumor necrosis factor Homo sapiens 187-196 34664888-2 2021 Systemic pro-inflammatory cytokines released from synovial tissues in rheumatoid arthritis, such as interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha, could have direct effects on cardiac electrophysiology, particularly changes in the expression and function of potassium and calcium channels, resulting in QT interval prolongation on surface electrocardiogram (ECG) and an increased predisposition to develop lethal ventricular arrhythmias. Potassium 274-283 tumor necrosis factor Homo sapiens 134-161 35087712-9 2022 Inflammatory cytokines IL-6 and TNF-alpha inhibit IKr and Ito repolarizing potassium currents. Potassium 75-84 tumor necrosis factor Homo sapiens 32-41 9384677-6 1995 Likewise, TNF-alpha and/or INF-gamma augmented T cell proliferation induced by CD80-transfected KS cells. Potassium 96-98 tumor necrosis factor Homo sapiens 10-19 34171450-12 2021 TNF-alpha demonstrated positive association with creatinine (r = 0.4,p = 0.006), BUN (r = 0.63,p = 0.003), sodium (r = 0.44, p = 0.04), potassium (r = 0.41, p = 0.04), and was negatively associated with RVFAC (r = -0.38,p = 0.03) and 6MWT distance (r = -0.54, p = 0.004). Potassium 136-145 tumor necrosis factor Homo sapiens 0-9 34334139-5 2021 These actions of sodium, potassium and magnesium and other minerals, trace elements and vitamins are likely to be secondary to their action on pro-inflammatory cytokines IL-6, TNF-alpha and IL-17 and metabolism of essential fatty acids that may account for their involvement in the pathobiology of insulin resistance, T2DM, HTN and autoimmune diseases. Potassium 25-34 tumor necrosis factor Homo sapiens 176-185