PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23274715-9 2013 The results suggest that MWCNT increases the excitability of hippocampal CA1 neurons by inhibiting voltage-gated potassium current. Potassium 113-122 carbonic anhydrase 1 Rattus norvegicus 73-76 22192952-0 2012 Inhibitory effect of tungsten carbide nanoparticles on voltage-gated potassium currents of hippocampal CA1 neurons. Potassium 69-78 carbonic anhydrase 1 Rattus norvegicus 103-106 23554830-0 2013 Saikosaponin a Enhances Transient Inactivating Potassium Current in Rat Hippocampal CA1 Neurons. Potassium 47-56 carbonic anhydrase 1 Rattus norvegicus 84-87 19895883-0 2010 Effect of melamine on potassium currents in rat hippocampal CA1 neurons. Potassium 22-31 carbonic anhydrase 1 Rattus norvegicus 60-63 20626758-0 2010 Effects of carvedilol on delayed rectifier and transient inactivating potassium currents in rat hippocampal CA1 neurons. Potassium 70-79 carbonic anhydrase 1 Rattus norvegicus 108-111 18623077-0 2009 In vitro study on influence of nano particles of CuO on CA1 pyramidal neurons of rat hippocampus potassium currents. Potassium 97-106 carbonic anhydrase 1 Rattus norvegicus 56-59 18623077-1 2009 The effects of nano particles of CuO on voltage-dependent potassium currents were studied in acutely isolated CA1 pyramidal neurons of rat hippocampus using the whole-cell patch-clamp techniques. Potassium 58-67 carbonic anhydrase 1 Rattus norvegicus 110-113 16706845-0 2006 Oxidative modulation of the transient potassium current IA by intracellular arachidonic acid in rat CA1 pyramidal neurons. Potassium 38-47 carbonic anhydrase 1 Rattus norvegicus 100-103 18441034-5 2008 We tested the hypothesis that potassium lateral diffusion coupling is responsible for the coupling mechanisms for network periodicity in a nonsynaptic model of epilepsy in vivo using a CA1 pyramidal neuron network model The simulation results show that 1), potassium lateral diffusion coupling is crucial for establishing epileptiform activity similar to that generated experimentally; and 2), there exists a scaling relation between the critical coupling strength and the number of cells in the network. Potassium 30-39 carbonic anhydrase 1 Rattus norvegicus 185-188 18385985-0 2008 Effects of Cd2+ on transient outward and delayed rectifier potassium currents in acutely isolated rat hippocampal CA1 neurons. Potassium 59-68 carbonic anhydrase 1 Rattus norvegicus 114-117 17317746-4 2007 By using patch-clamp recordings from acute rat hippocampal slices we show that D-type potassium current modulates the size of the ADP and the bursting of CA1 pyramidal neurons. Potassium 86-95 carbonic anhydrase 1 Rattus norvegicus 154-157 17150193-8 2007 This suggested that the OL in CA1 region could sense the neuronal activity and contribute to potassium clearance. Potassium 93-102 carbonic anhydrase 1 Rattus norvegicus 30-33 12096059-1 2002 Brief pressure ejection of solutions containing potassium, caesium or rubidium ions into stratum radiatum of the CA1 or CA3 regions of the hippocampal slice evoked a fast network oscillation. Potassium 48-57 carbonic anhydrase 1 Rattus norvegicus 113-116 16148750-0 2005 Effects of copper on A-type potassium currents in acutely dissociated rat hippocampal CA1 neurons. Potassium 28-37 carbonic anhydrase 1 Rattus norvegicus 86-89 16148750-5 2005 This study indicated that copper reversibly inhibits the hippocampal CA1 neuronal voltage-gated A-type potassium current in a dose-dependent and voltage-dependent manner, and such actions are likely involved in the regulation of the neuronal excitability and the pathophysiology of Wilson"s disease. Potassium 103-112 carbonic anhydrase 1 Rattus norvegicus 69-72 15621334-0 2005 Effects of sodium metabisulfite on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Potassium 35-44 carbonic anhydrase 1 Rattus norvegicus 74-77 15621334-1 2005 The effects of sodium metabisulfite (SMB), a food preservative mostly used in food and drug industries, on voltage-dependent potassium currents in acutely isolated hippocampal CA1 pyramidal neurons of rat were studied using the whole-cell patch-clamp techniques. Potassium 125-134 carbonic anhydrase 1 Rattus norvegicus 176-179 15374744-0 2004 Sodium-activated potassium conductance participates in the depolarizing afterpotential following a single action potential in rat hippocampal CA1 pyramidal cells. Potassium 17-26 carbonic anhydrase 1 Rattus norvegicus 142-145 15234075-5 2004 These results imply that AlCl3 could affect the activation and inactivation courses of sodium current and potassium current of rat hippocampal CA1 neurons, which may contribute to damage of the central nervous system by aluminum. Potassium 106-115 carbonic anhydrase 1 Rattus norvegicus 143-146 15066048-0 2004 Melatonin inhibits outward delayed rectifier potassium currents in hippocampal CA1 pyramidal neuron via intracellular indole-related domains. Potassium 45-54 carbonic anhydrase 1 Rattus norvegicus 79-82 21162184-0 2005 [Effects of sodium metabisulfite on potassium currents in acutely isolated rat hippocampal CA1 neurons]. Potassium 36-45 carbonic anhydrase 1 Rattus norvegicus 91-94 14746925-0 2004 Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Potassium 24-33 carbonic anhydrase 1 Rattus norvegicus 63-66 12937818-1 2003 The effects of aluminum chloride (AlCl3) on the transient outward potassium and delayed rectifier K(+) current in hippocampal CA1 neurons of rats were studied by the whole-cell patch clamp technique. Potassium 66-75 carbonic anhydrase 1 Rattus norvegicus 126-129 12421609-10 2002 Treatment of recovered slices with high potassium for 90 s causes the re-appearance of CaMKII clusters in nearly all CA1 pyramidal cells examined. Potassium 40-49 carbonic anhydrase 1 Rattus norvegicus 117-120 9819250-0 1998 Potassium conductance causing hyperpolarization of CA1 hippocampal neurons during hypoxia. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 51-54 11169627-0 2001 Reduced potassium currents in old rat CA1 hippocampal neurons. Potassium 8-17 carbonic anhydrase 1 Rattus norvegicus 38-41 11169627-2 2001 We compared potassium currents in CA1 hippocampal neurons dissociated from young (2-3 months old) and old (26-30 months old) Sprague-Dawley rats. Potassium 12-21 carbonic anhydrase 1 Rattus norvegicus 34-37 11169627-11 2001 This reduction of potassium currents could account for the prolongation of action potentials reported previously for old rat CA1 hippocampal neurons. Potassium 18-27 carbonic anhydrase 1 Rattus norvegicus 125-128 10686402-0 2000 Potassium currents in CA1 neurons of rat hippocampus increase shortly after transient cerebral ischemia. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 22-25 10686402-1 2000 Total potassium current in CA1 pyramidal neurons was studied using whole-cell voltage-clamp recording technique in hippocampal slices prepared before and at 6-8 h after transient forebrain ischemia. Potassium 6-15 carbonic anhydrase 1 Rattus norvegicus 27-30 10686402-4 2000 These results indicate that the increase of potassium current might be responsible for the decreased excitability in CA1 neurons after severe ischemia and may be involved in postischemic cell death in hippocampus. Potassium 44-53 carbonic anhydrase 1 Rattus norvegicus 117-120 10618149-7 2000 Sustained outward potassium currents, recorded in both whole-cell and outside-out patch configurations, demonstrated a selective reduction of amplitude only in antisense-treated CA1 pyramidal neurones. Potassium 18-27 carbonic anhydrase 1 Rattus norvegicus 178-181 10411997-4 1999 The estimated reversal potential of this T-588 effect was near -90 mV which is the reversal potential of potassium ions in CA1 neurons. Potassium 105-114 carbonic anhydrase 1 Rattus norvegicus 123-126 10411997-5 1999 In the whole-cell voltage-clamp study, T-588 produced a reversible block of the outward potassium current in CA1 neurons. Potassium 88-97 carbonic anhydrase 1 Rattus norvegicus 109-112 10411997-7 1999 These results suggest that T-588 has a direct effect on CA1 neurons independent of its cholinergic activity, resulting from blockade of a conductance carried predominantly by potassium ions. Potassium 175-184 carbonic anhydrase 1 Rattus norvegicus 56-59 11972176-0 1999 [Effects of glutamate on transient outward potassium current of dissociated hippocampal neurons in ca1 sector in rats]. Potassium 43-52 carbonic anhydrase 1 Rattus norvegicus 99-102 11245064-0 1998 Effects of beta-amyloid peptide on transient outward potassium current of acutely dissociated hippocampal neurons in CA1 sector in rats. Potassium 53-62 carbonic anhydrase 1 Rattus norvegicus 117-120 9693779-0 1998 Sustained potassium currents in maturing CA1 hippocampal neurones. Potassium 10-19 carbonic anhydrase 1 Rattus norvegicus 41-44 9227836-2 1997 The present study examined the activation of CaM-kinase II (calcium/calmodulin-dependent protein kinase II) in CA1 and CA3 areas after glutamate or potassium stimulation. Potassium 148-157 carbonic anhydrase 1 Rattus norvegicus 111-114 9509993-0 1998 Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats. Potassium 63-72 carbonic anhydrase 1 Rattus norvegicus 95-98 9437012-8 1998 Additionally, RGS4 markedly attenuates the mGluR5-mediated inhibition of potassium currents in hippocampal CA1 neurons. Potassium 73-82 carbonic anhydrase 1 Rattus norvegicus 107-110 8728473-0 1996 Tetrahydroberberine suppresses dopamine-induced potassium current in acutely dissociated CA1 pyramidal neurons from rat hippocampus. Potassium 48-57 carbonic anhydrase 1 Rattus norvegicus 89-92 8719027-1 1996 The 5-hydroxytryptamine1A (5-HT1A) receptor in the CA1 region of the hippocampus is linked through a G protein to an inwardly rectifying potassium conductance. Potassium 137-146 carbonic anhydrase 1 Rattus norvegicus 51-54 8640353-2 1995 We have studied three hypoxia-induced phenomena in the CA1 stratum pyramidale of the rat hippocampal slice: (a) the increase in extracellular potassium ion concentration ([K+]e) measured with ion-sensitive microelectrodes, (b) the intracellularly-recorded pyramidal cell hyperpolarization and (c) the extracellularly-recorded depression of the synaptically-evoked field potential recorded in stratum pyramidale. Potassium 142-151 carbonic anhydrase 1 Rattus norvegicus 55-58 8592191-2 1995 The properties of voltage-gated potassium currents were studied in acutely isolated rat hippocampal pyramidal cells from area CA1 and CA3 at postnatal ages of day 6-8, 9-14, and 26-29 (P6-8, P9-14, and P26-29) with the use of the whole cell version of the patch-clamp technique. Potassium 32-41 carbonic anhydrase 1 Rattus norvegicus 126-129 8576855-0 1995 Voltage-gated potassium currents in stratum oriens-alveus inhibitory neurones of the rat CA1 hippocampus. Potassium 14-23 carbonic anhydrase 1 Rattus norvegicus 89-92 8576856-0 1995 Potassium conductances underlying repolarization and after-hyperpolarization in rat CA1 hippocampal interneurones. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 84-87 7690067-3 1993 Elevating extracellular potassium concentration (50 mM, 1 min) evoked the calcium-dependent release of both ASP (approximately 50% increase) and GLU (approximately 200% increase) from hippocampal slices and from minislices of area CA1. Potassium 24-33 carbonic anhydrase 1 Rattus norvegicus 231-234 7472364-2 1995 An in vitro slice model of ischemia was used to study changes in extracellular potassium concentration and diffusion properties in the stratum pyramidale of CA1 and CA3 regions of the hippocampus and in the cortex of the rat. Potassium 79-88 carbonic anhydrase 1 Rattus norvegicus 157-160 7472364-6 1995 The bathing medium contained 5 mM potassium, and in vitro ischemia caused the potassium concentration to rise to 45 mM in CA1, 12 mM in CA3, and 32 mM in cortex. Potassium 78-87 carbonic anhydrase 1 Rattus norvegicus 122-125 7697882-0 1994 Potassium currents in acutely isolated maturing rat hippocampal CA1 neurones. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 64-67 7697882-1 1994 Whole-cell voltage clamp techniques were used to characterize the postnatal development of current amplitude and inactivation and activation kinetics of two potassium currents in acutely isolated CA1 cells from rats P4 to P52: the A-current (IA) and a slow-rising, slow inactivating current (IK). Potassium 157-166 carbonic anhydrase 1 Rattus norvegicus 196-199 8145166-0 1993 Potassium currents operated by thyrotrophin-releasing hormone in dissociated CA1 pyramidal neurones of rat hippocampus. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 77-80 7552366-0 1995 Hydrogen peroxide hyperpolarizes rat CA1 pyramidal neurons by inducing an increase in potassium conductance. Potassium 86-95 carbonic anhydrase 1 Rattus norvegicus 37-40 7552366-10 1995 We suggest that hydrogen peroxide is able to induce an increase in potassium conductance in rat CA1 pyramidal neurons. Potassium 67-76 carbonic anhydrase 1 Rattus norvegicus 96-99 7790911-0 1995 Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons. Potassium 67-76 carbonic anhydrase 1 Rattus norvegicus 97-100 7651611-0 1995 Potassium currents in isolated CA1 neurons of the rat after kindling epileptogenesis. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 31-34 8306432-0 1993 Potassium-induced changes in excitability in the hippocampal CA1 region of immature and adult rats. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 61-64 8492147-0 1993 Serotonin-operated potassium current in CA1 neurons dissociated from rat hippocampus. Potassium 19-28 carbonic anhydrase 1 Rattus norvegicus 40-43 8330198-1 1993 In this study we examined long-lasting effects mediated by intracellular mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) on two voltage dependent potassium conductances in CA1 pyramidal neurons, i.e. the transient current IA and the delayed rectifier, and on the inward rectifier IQ, a mixed sodium/potassium current. Potassium 167-176 carbonic anhydrase 1 Rattus norvegicus 193-196 8330198-1 1993 In this study we examined long-lasting effects mediated by intracellular mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) on two voltage dependent potassium conductances in CA1 pyramidal neurons, i.e. the transient current IA and the delayed rectifier, and on the inward rectifier IQ, a mixed sodium/potassium current. Potassium 320-329 carbonic anhydrase 1 Rattus norvegicus 193-196 1355004-2 1992 Hyperpolarization is caused by an increased potassium conductance that is attenuated by glibenclamide (1-10 microM), a selective antagonist of ATP-sensitive potassium channels; in contrast, diazoxide (0.5 mM), an agonist at this channel, induces a hyperpolarization in CA1 neurons of rat hippocampal slices. Potassium 44-53 carbonic anhydrase 1 Rattus norvegicus 269-272 8384511-1 1993 In the CA1 region of rat hippocampal slices, spreading depression (SD) was provoked by a brief period of hypoxia or by localized application of high potassium solution. Potassium 149-158 carbonic anhydrase 1 Rattus norvegicus 7-10 1472982-2 1992 The transient potassium current was recorded in single hippocampal CA1 neurones from the rat by use of the whole-cell patch clamp technique. Potassium 14-23 carbonic anhydrase 1 Rattus norvegicus 67-70 1356568-0 1992 Strychnine-induced potassium current in CA1 pyramidal neurones of the rat hippocampus. Potassium 19-28 carbonic anhydrase 1 Rattus norvegicus 40-43 8095426-0 1993 Perfusion with high potassium plus glutamate can cause LTP erasure or persistent loss of neuronal responsiveness in the CA1 region of the hippocampal slice. Potassium 20-29 carbonic anhydrase 1 Rattus norvegicus 120-123 7907456-15 1993 Furthermore, GABA can readily be released upon potassium stimulation in the period preceding CA1 pyramidal cell death. Potassium 47-56 carbonic anhydrase 1 Rattus norvegicus 93-96 1354553-1 1992 We observed that a transient increase in extracellular potassium concentration (50 mM for 40 s) was sufficient to induce long-term potentiation (LTP) of synaptic transmission in area CA1 of the hippocampal slice. Potassium 55-64 carbonic anhydrase 1 Rattus norvegicus 183-186 1522756-3 1992 The latency to obtain a 50% decrease in the amplitude of the CA1 population spike (CA1 PS) during a short- (5-10 min) lasting hypoxic period was significantly increased (P less than 0.01) by slice perfusion with caffeine (50 microM), DPCPX (0.2 microM), and by increasing (from 3 to 4 mM) the potassium concentration in the medium bathing the hippocampal slices. Potassium 293-302 carbonic anhydrase 1 Rattus norvegicus 61-64 1522756-3 1992 The latency to obtain a 50% decrease in the amplitude of the CA1 population spike (CA1 PS) during a short- (5-10 min) lasting hypoxic period was significantly increased (P less than 0.01) by slice perfusion with caffeine (50 microM), DPCPX (0.2 microM), and by increasing (from 3 to 4 mM) the potassium concentration in the medium bathing the hippocampal slices. Potassium 293-302 carbonic anhydrase 1 Rattus norvegicus 83-86 1993123-1 1991 Opioid receptors were found to activate two different types of membrane potassium conductance in acutely dissociated neurons from the CA1/subiculum regions of the adult rat hippocampal formation. Potassium 72-81 carbonic anhydrase 1 Rattus norvegicus 134-137 1905577-6 1991 Biochemical features revealed by high potassium stimulation may be an expression of "delayed neuronal death" in the hippocampal CA1 area. Potassium 38-47 carbonic anhydrase 1 Rattus norvegicus 128-131 2559967-13 1989 We conclude that this adenosine inhibition is mediated by an increase in a voltage- and calcium-insensitive potassium conductance in CA1 neurones. Potassium 108-117 carbonic anhydrase 1 Rattus norvegicus 133-136 2302557-0 1990 Effects of extracellular potassium concentration and postsynaptic membrane potential on calcium-induced potentiation in area CA1 of rat hippocampus. Potassium 25-34 carbonic anhydrase 1 Rattus norvegicus 125-128 2887177-6 1987 Potassium-stimulated, Ca2+-dependent release of [3H]glutamate was significantly greater in slices of dentate gyrus and area CA1 prepared from conditioned animals than from pseudoconditioned animals. Potassium 0-9 carbonic anhydrase 1 Rattus norvegicus 124-127 2723735-2 1989 Focal electrographic seizures arose in the CA1 region of rat hippocampal slices bathed in elevated (8.5 mM) external potassium [( K+]o). Potassium 117-126 carbonic anhydrase 1 Rattus norvegicus 43-46 3655875-0 1987 Activity-evoked increases in extracellular potassium modulate presynaptic excitability in the CA1 region of the hippocampus. Potassium 43-52 carbonic anhydrase 1 Rattus norvegicus 94-97 3655875-12 1987 Concomitant with changes in the excitability of CA1 afferents, the concentration of extracellular potassium ( [K+]o) increased up to 7 mM, as recorded in the stratum radiatum with potassium ion-sensitive microelectrodes. Potassium 98-107 carbonic anhydrase 1 Rattus norvegicus 48-51 3655875-12 1987 Concomitant with changes in the excitability of CA1 afferents, the concentration of extracellular potassium ( [K+]o) increased up to 7 mM, as recorded in the stratum radiatum with potassium ion-sensitive microelectrodes. Potassium 180-189 carbonic anhydrase 1 Rattus norvegicus 48-51 2839527-4 1988 The results showed significant accumulation of calcium and loss of potassium after 3 and 4 days of recovery in the CA1 sector, which developed neuronal necrosis, but not in the CA3 sector, which showed only occasional damage. Potassium 67-76 carbonic anhydrase 1 Rattus norvegicus 115-118 2992681-3 1985 The post-hypoxic hyperexcitability of CA1 neurons may be the result of their inability to fully recover intracellular potassium lost during oxygen deprivation. Potassium 118-127 carbonic anhydrase 1 Rattus norvegicus 38-41 32736087-0 2020 5-HT7 receptors increase the excitability of hippocampal CA1 pyramidal neurons by inhibiting the A-type potassium current. Potassium 104-113 carbonic anhydrase 1 Rattus norvegicus 57-60 30611209-0 2019 Inhibitory effect of ultrasonic stimulation on the voltage-dependent potassium currents in rat hippocampal CA1 neurons. Potassium 69-78 carbonic anhydrase 1 Rattus norvegicus 107-110 29317612-3 2018 We discovered the development of this activity in the CA1 region of horizontal slices after prolonged interictal-like epileptiform activity in the CA3 region that was provoked by incubation in high potassium artificial cerebrospinal fluid. Potassium 198-207 carbonic anhydrase 1 Rattus norvegicus 54-57 2999648-0 1985 Effects of noradrenaline on some potassium currents in CA1 neurones in rat hippocampal slices. Potassium 33-42 carbonic anhydrase 1 Rattus norvegicus 55-58