PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27421477-3 2016 We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow-derived dendritic cells, mouse neutrophils, and human PBMCs. Potassium 276-285 NLR family, pyrin domain containing 3 Mus musculus 64-69 33490276-16 2021 LpqH protein has good immunogenicity and can activate the NLRP3 inflammasome through the potassium efflux pathway without causing cell death. Potassium 89-98 NLR family, pyrin domain containing 3 Mus musculus 58-63 33135287-9 2020 In addition, the GSDMD pore results in potassium efflux that can activate the NLRP3 inflammasome. Potassium 39-48 NLR family, pyrin domain containing 3 Mus musculus 78-83 32353421-0 2020 NEK7 mediated assembly and activation of NLRP3 inflammasome downstream of potassium efflux in ventilator-induced lung injury. Potassium 74-83 NLR family, pyrin domain containing 3 Mus musculus 41-46 32353421-7 2020 Mechanical stretch exaggerated the interaction between NEK7 and NLRP3, leading to assembly and activation of NLRP3 inflammasome downstream of potassium efflux. Potassium 142-151 NLR family, pyrin domain containing 3 Mus musculus 64-69 32353421-7 2020 Mechanical stretch exaggerated the interaction between NEK7 and NLRP3, leading to assembly and activation of NLRP3 inflammasome downstream of potassium efflux. Potassium 142-151 NLR family, pyrin domain containing 3 Mus musculus 109-114 30092543-5 2018 PM2.5 could be internalized into cells through multiple endocytosis processes, such as phagocytosis and pinocytosis (macropinocytosis, clathrin- and caveolin-mediated endocytosis), and activate NLRP3 inflammasome through cathepsin B release, ROS production, and potassium efflux. Potassium 262-271 NLR family, pyrin domain containing 3 Mus musculus 194-199 29958799-1 2018 Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Potassium 0-9 NLR family, pyrin domain containing 3 Mus musculus 105-110 26891693-8 2016 The formation of NLRP3/ASC/caspase-8 specks in response to TNFalpha/CHX was downstream of TNFR signaling and dependent on potassium efflux. Potassium 122-131 NLR family, pyrin domain containing 3 Mus musculus 17-22 26553871-5 2016 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium 64-73 NLR family, pyrin domain containing 3 Mus musculus 38-43 26683666-10 2016 These findings suggest that generation of reactive oxygen species and potassium efflux contribute to HIV-induced pyroptosis and NLRP3 inflammasome activation in podocytes. Potassium 70-79 NLR family, pyrin domain containing 3 Mus musculus 128-133 26553871-5 2016 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium 64-73 NLR family, pyrin domain containing 3 Mus musculus 97-102 26553871-5 2016 Although it has been shown that known Nlrp3 stimuli converge on potassium ion efflux upstream of Nlrp3 activation, the exact molecular mechanism of Nlrp3 activation remains elusive. Potassium 64-73 NLR family, pyrin domain containing 3 Mus musculus 97-102 26553871-7 2016 We employed a FACS-based screen for Nlrp3-dependent cell death, using the ionophoric compound nigericin as a potassium efflux-inducing stimulus. Potassium 109-118 NLR family, pyrin domain containing 3 Mus musculus 36-41 25404286-6 2014 LT-induced NLRP1b inflammasome activation was shown to be impaired upon inhibition of potassium efflux, which is known to play a major role in NLRP3 inflammasome formation and ASC dimerization. Potassium 86-95 NLR family, pyrin domain containing 3 Mus musculus 143-148 21625424-5 2011 All three drugs induced potassium efflux from the cells as a known mechanism for NLRP3 activation but the P2X7 receptor was not required for this process. Potassium 24-33 NLR family, pyrin domain containing 3 Mus musculus 81-86 22768222-5 2012 We show that activation of NALP3 depends on phagocytosis of dying cells, ATP release through pannexin-1 channels of dying autophagic cells, P(2)X(7) purinergic receptor activation, and on consequent potassium efflux. Potassium 199-208 NLR family, pyrin domain containing 3 Mus musculus 27-32 22606244-1 2012 Some inflammatory stimuli trigger activation of the NLRP3 inflammasome by inducing efflux of cellular potassium. Potassium 102-111 NLR family, pyrin domain containing 3 Mus musculus 52-57 22606244-9 2012 Despite the inability of these inhibitors to trigger efflux of intracellular potassium, the addition of high extracellular potassium suppressed activation of the NLRP3 inflammasome. Potassium 123-132 NLR family, pyrin domain containing 3 Mus musculus 162-167 21464611-11 2011 As with other agents that induce activation of the NLRP3 inflammasome, the ability of doxorubicin to provide proinflammatory danger signals was inhibited by co-treatment of cells with ROS inhibitors or by incubating cells in high extracellular potassium. Potassium 244-253 NLR family, pyrin domain containing 3 Mus musculus 51-56 21625424-7 2011 Together, the polyene macrolides amphotericin B, nystatin, and natamycin trigger IL-1beta secretion by causing potassium efflux from which activates the NLRP3-ASC-caspase-1. Potassium 111-120 NLR family, pyrin domain containing 3 Mus musculus 153-158 34341510-2 2022 TWIK2 potassium channel mediates potassium efflux that has been reported to be an essential upstream mechanism for ATP-induced NLRP3 inflammasome activation. Potassium 33-42 NLR family, pyrin domain containing 3 Mus musculus 127-132 34987507-5 2021 Instead, FK866 facilitated robust caspase-1 activation in BMDMs in the presence of NLRP3-activating signals such as ATP and nigericin, a potassium ionophore. Potassium 137-146 NLR family, pyrin domain containing 3 Mus musculus 83-88 34349235-10 2022 Furthermore, in cardiomyocytes, ISO increased the efflux of potassium and the generation of ROS, which are recognized as activators of the NLRP3 inflammasome. Potassium 60-69 NLR family, pyrin domain containing 3 Mus musculus 139-144 35252186-3 2022 Mechanismly, manoalide inhibited the NLRP3 inflammasome activation by acting downstream of potassium efflux, chloride efflux and mitochondrial dysfunction. Potassium 91-100 NLR family, pyrin domain containing 3 Mus musculus 37-42 35353387-3 2022 A commonly reported mechanism contributing to NLRP3 inflammasome activation is potassium ion (K+ ) efflux across the plasma membrane. Potassium 79-88 NLR family, pyrin domain containing 3 Mus musculus 46-51 35371034-6 2022 Next, our work showed that PLO can form pores in the cell membrane, leading to the efflux of potassium (K+), NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated caspase-1 activation, and gasdermin D (GSDMD) cleavage. Potassium 93-102 NLR family, pyrin domain containing 3 Mus musculus 161-166