PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25318749-0 2014 Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration. Potassium 24-33 ETS transcription factor ERG Homo sapiens 19-23 25903789-5 2015 METHODS: Lacosamide was tested in vitro on sodium and L-type calcium currents from isolated human atrial myocytes and on hERG-mediated potassium currents from stably transfected HEK293 cells. Potassium 135-144 ETS transcription factor ERG Homo sapiens 121-125 25318749-2 2014 Ionic current carried by hERG channels (IhERG) is known to exhibit a paradoxical dependence on external potassium concentration ([K(+)]e), but effects of acute [K(+)]e changes on the response of IhERG to premature stimulation have not been characterized. Potassium 104-113 ETS transcription factor ERG Homo sapiens 25-29 23020479-5 2012 A Hodgkin-Huxley-style cardiac ionic model captured the different types of complex dynamics following blockage of the hERG mediated potassium current. Potassium 132-141 ETS transcription factor ERG Homo sapiens 118-122 23792956-4 2013 Our recent data indicate that hERG channels undergo enhanced endocytic degradation under low potassium (hypokalemia) conditions. Potassium 93-102 ETS transcription factor ERG Homo sapiens 30-34 23241319-1 2013 KCNQ1 and hERG encode the voltage-gated potassium channel alpha-subunits of the cardiac repolarizing currents I(Ks) and I(Kr), respectively. Potassium 112-114 ETS transcription factor ERG Homo sapiens 10-14 23241319-4 2013 Biochemical assays indicated direct, protein-protein interactions between KCNQ1 and hERG may underlie the interplay between I(Ks) and I(Kr). Potassium 126-128 ETS transcription factor ERG Homo sapiens 84-88 21888984-1 2011 INTRODUCTION: Measurement of drug-induced inhibition of potassium current flow through the hERG channel is used to determine potency at the channel, which is used as an in vitro risk assessment for QTc interval prolongation in vivo. Potassium 56-65 ETS transcription factor ERG Homo sapiens 91-95 22303293-1 2012 The Patchliner temperature-controlled automated patch clamp system was evaluated for testing drug effects on potassium currents through human ether-a-go-go related gene (hERG) channels expressed in Chinese hamster ovary cells at 35-37 C. IC(50) values for a set of reference drugs were compared with those obtained using the conventional voltage clamp technique. Potassium 110-119 ETS transcription factor ERG Homo sapiens 171-175 23133669-2 2012 Unlike most voltage-gated K(+)-channels, hERG shows a low elementary conductance at physiological voltage and potassium concentration. Potassium 110-119 ETS transcription factor ERG Homo sapiens 41-45 21120454-5 2011 hERG channels were expressed in Xenopus laevis oocytes and human embryonic kidney (HEK 293) cells, and potassium currents were recorded using patch clamp and two-electrode voltage clamp electrophysiology. Potassium 103-112 ETS transcription factor ERG Homo sapiens 0-4 21484263-4 2011 To assess this, we examined the effects of the female sex hormone beta-estradiol on the human ether-a-go-go-related gene (hERG)-encoded potassium current stably expressed in human embryonic kidney-293 (HEK) cells. Potassium 136-145 ETS transcription factor ERG Homo sapiens 122-126 21158686-1 2010 The voltage-gated potassium channel, human Ether-a-go-go related gene (hERG), represents the molecular component of IKr, one of the potassium currents involved in cardiac action potential repolarization. Potassium 18-27 ETS transcription factor ERG Homo sapiens 71-75 21774764-2 2011 Based on kinetic properties and drug sensitivity it is composed of a slow (I(Ks)) and a rapid (I(Kr)) component, the latter is mediated by hERG channels. Potassium 77-79 ETS transcription factor ERG Homo sapiens 139-143 20607461-1 2010 The human ether a go-go related gene (hERG) voltage-gated potassium controls the rapid delayed rectifier potassium current (I(ks)) in heart. Potassium 58-67 ETS transcription factor ERG Homo sapiens 38-42 20607461-1 2010 The human ether a go-go related gene (hERG) voltage-gated potassium controls the rapid delayed rectifier potassium current (I(ks)) in heart. Potassium 126-128 ETS transcription factor ERG Homo sapiens 38-42 20607461-1 2010 The human ether a go-go related gene (hERG) voltage-gated potassium controls the rapid delayed rectifier potassium current (I(ks)) in heart. Potassium 105-114 ETS transcription factor ERG Homo sapiens 38-42 18651412-3 2008 Inhibition of hERG potassium currents by class III antiarrhythmic drugs causes lengthening of cardiac action potential, which produces a beneficial antiarrhythmic effect. Potassium 19-28 ETS transcription factor ERG Homo sapiens 14-18 19903464-0 2010 Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652. Potassium 34-43 ETS transcription factor ERG Homo sapiens 29-33 19159406-18 2009 Electrophysiological testing revealed low-affinity inhibition of the potassium current through hERG channels expressed in HEK293 cells (IC(50) = 171 microM oxycodone). Potassium 69-78 ETS transcription factor ERG Homo sapiens 95-99 18042732-11 2008 During a voltage-clamp protocol using a prerecorded cardiac action potential, 3 muM PD-307243 increased the total potassium ions passed through hERG channels by 8.8 +/- 1.0-fold (n = 5). Potassium 114-123 ETS transcription factor ERG Homo sapiens 144-148 20229012-5 2010 hERG channels were expressed in Xenopus laevis oocytes and HEK 293 cells, and potassium currents were recorded using patch clamp and two-electrode voltage clamp electrophysiology. Potassium 78-87 ETS transcription factor ERG Homo sapiens 0-4 20738248-4 2010 The drug-induced blockade of the hERG-related component of the potassium current is thought to be a major reason for drug-induced arrhythmias in humans. Potassium 63-72 ETS transcription factor ERG Homo sapiens 33-37 18772606-6 2008 The effect of CHP-NY-ESO-1 on the hERG-dependent potassium currents was also examined using in vitro cultured cell system, and no inhibition of hERG currents was observed. Potassium 49-58 ETS transcription factor ERG Homo sapiens 34-38 17699694-4 2007 We find that although the plateau potentials are mediated by a voltage-gated Ca(2+) current, they do not depend on the accumulation of cytosolic Ca(2+), then use a computational model to test the hypothesis that the slowly voltage-activated ether-a-go-go-related gene (ERG) potassium current repolarizes the plateaus. Potassium 274-283 ETS transcription factor ERG Homo sapiens 241-267 18998101-0 2008 Recording hERG potassium currents and assessing the effects of compounds using the whole-cell patch-clamp technique. Potassium 15-24 ETS transcription factor ERG Homo sapiens 10-14 17363390-0 2007 Modulation of hERG potassium currents in HEK-293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits. Potassium 19-28 ETS transcription factor ERG Homo sapiens 14-18 17477915-0 2007 Reduction of hERG potassium currents by hyperosmolar solutions. Potassium 18-27 ETS transcription factor ERG Homo sapiens 13-17 17477915-1 2007 We investigated the effects of hyperosmolar solutions on human ether-a-go-go related gene (hERG) potassium currents in chinese hamster ovary (CHO) cells. Potassium 97-106 ETS transcription factor ERG Homo sapiens 91-95 17590357-0 2007 Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential. Potassium 124-133 ETS transcription factor ERG Homo sapiens 119-123 16506891-4 2006 hERG-transfected human embryonic kidney-293 cells were cultured on 96-well assay plates and loaded with rubidium ion by incubating in media in which potassium was replaced by 5.4 mM Rb+. Potassium 149-158 ETS transcription factor ERG Homo sapiens 0-4 16971508-8 2006 Amiodarone, B2-O-acetate, and B2-O-Et-N-dipropyl (each 10 microM) significantly reduced the hERG tail current amplitude, whereas 10 microM B2-O-Et displayed no detectable effect on hERG outward potassium currents. Potassium 194-203 ETS transcription factor ERG Homo sapiens 92-96 16928897-11 2006 During a voltage-clamp protocol using prerecorded cardiac action potentials, 2.5 microM MTX increased the total potassium ions passed through hERG channels by approximately 5-fold. Potassium 112-121 ETS transcription factor ERG Homo sapiens 142-146 16495758-0 2006 Flunarizine is a highly potent inhibitor of cardiac hERG potassium current. Potassium 57-66 ETS transcription factor ERG Homo sapiens 52-56 16495758-3 2006 We examined the effects of flunarizine on potassium currents through cardiac channels encoded by the human ether-a-go-go related gene (hERG) stably expressed in CHO cells. Potassium 42-51 ETS transcription factor ERG Homo sapiens 135-139 16495758-4 2006 In this study, we have characterized the effect of flunarizine on biophysical properties of hERG potassium currents with standard whole-cell voltage-clamp techniques. Potassium 97-106 ETS transcription factor ERG Homo sapiens 92-96 16495758-6 2006 The effect of flunarizine on hERG potassium current is concentration and time dependent, and displays voltage dependence over the voltage range between -40 and 0 mV. Potassium 34-43 ETS transcription factor ERG Homo sapiens 29-33 15922632-0 2005 Additive effects of ziprasidone and D,L-sotalol on the action potential in rabbit Purkinje fibres and on the hERG potassium current. Potassium 114-123 ETS transcription factor ERG Homo sapiens 109-113 16610352-1 2006 The human ether-a-go-go-related gene (hERG) encodes an ion channel subunit underlying IKr, a potassium current required for the normal repolarization of ventricular cells in the human heart. Potassium 93-102 ETS transcription factor ERG Homo sapiens 38-42 15716081-0 2005 Effects of the antiepileptic drugs lamotrigine, topiramate and gabapentin on hERG potassium currents. Potassium 82-91 ETS transcription factor ERG Homo sapiens 77-81 15800067-3 2005 We previously demonstrated that the activation of integrins containing the beta(1) subunit leads to a selective increase in potassium currents carried by the human ether-a-go-go-related gene (hERG) channels in neuroblastoma and leukemia cells; this current activation modulates adhesion-dependent differentiation in these cells. Potassium 124-133 ETS transcription factor ERG Homo sapiens 192-196 16050264-2 2005 The voltage-gated potassium channel formed by hERG pore-forming alpha subunits generates the IKr cardiac potassium current, and is considered essential for human ventricular repolarization. Potassium 18-27 ETS transcription factor ERG Homo sapiens 46-50 15172012-5 2004 This includes (1) testing for blockade of I(Kr) or hERG-mediated potassium current in heterologous cell systems, (2) measurement of effects on the myocardial action potential in vitro; and (3) assessment of effects on the ECG in a well-conducted in vivo study. Potassium 65-74 ETS transcription factor ERG Homo sapiens 51-55 15365637-11 2004 In summary, cardiac repolarizing hERG/I(Kr) potassium currents are modulated by alpha(1A)-adrenoceptors via PKC and PKA independently of direct channel phosphorylation. Potassium 44-53 ETS transcription factor ERG Homo sapiens 33-37 15573468-8 2004 We investigated the effects of DW-224a on the human ether-a-go-go-related gene (hERG) mediated potassium currents to evaluate its potential to induce QT interval prolongation. Potassium 95-104 ETS transcription factor ERG Homo sapiens 80-84 15235086-0 2004 Muscarinic modulation of erg potassium current. Potassium 29-38 ETS transcription factor ERG Homo sapiens 25-28 10804231-7 2000 Given the pharmacological properties of potassium homeostasis (sensitivity to Cs(+)), members of the ether-a-go-go (ERG) channel family widely expressed in the nervous system could underlie part of the process. Potassium 40-49 ETS transcription factor ERG Homo sapiens 101-114 14613852-2 2003 Mutations in the human-ether-a-go-go-related gene (hERG), encoding the protein underlying the repolarizing cardiac I(Kr) potassium current, cause chromosome 7-linked long QT syndrome 2. Potassium 121-130 ETS transcription factor ERG Homo sapiens 51-55 10804231-7 2000 Given the pharmacological properties of potassium homeostasis (sensitivity to Cs(+)), members of the ether-a-go-go (ERG) channel family widely expressed in the nervous system could underlie part of the process. Potassium 40-49 ETS transcription factor ERG Homo sapiens 116-119 10804231-9 2000 Specific ERG blockers (dofetilide and E 4031) inhibited hyperpolarization- and depolarization-activated glial currents, and ERG blockade impaired clearance of extracellular potassium with little direct effect on hippocampal neuron excitability. Potassium 173-182 ETS transcription factor ERG Homo sapiens 124-127 10804231-14 2000 This study provides insight into a possible physiological role of hippocampal ERG channels and links activation of ERG to control of potassium homeostasis. Potassium 133-142 ETS transcription factor ERG Homo sapiens 78-81 10804231-14 2000 This study provides insight into a possible physiological role of hippocampal ERG channels and links activation of ERG to control of potassium homeostasis. Potassium 133-142 ETS transcription factor ERG Homo sapiens 115-118 33147278-1 2020 The human ether-a-go-go-related voltage-gated cardiac ion channel (commonly known as hERG) conducts the rapid outward repolarizing potassium current in cardiomyocytes (IKr). Potassium 131-140 ETS transcription factor ERG Homo sapiens 85-89 34757159-1 2021 The human ether-a-go-go-related gene (hERG) encodes the Kv11.1 voltage-gated potassium ion (K+) channel that conducts the rapidly activating delayed rectifier current (Ikr) in cardiomyocytes to regulate the repolarization process. Potassium 77-86 ETS transcription factor ERG Homo sapiens 38-42 34736759-1 2021 INTRODUCTION: Drug-induced block of the hERG potassium channel could predispose to torsade de pointes, depending on occurrence of concomitant blocks of the calcium and/or sodium channels. Potassium 45-54 ETS transcription factor ERG Homo sapiens 40-44 35087712-6 2022 The pro-arrhythmic action results from drug-induced inhibition of Kv11.1 (hERG) channels interfering with the repolarizing potassium IKr currents, leading to long QT and increased risk of triggered arrhythmias. Potassium 123-132 ETS transcription factor ERG Homo sapiens 74-78 33829343-1 2021 The human ether-a-go-go related gene (hERG, KCNH2) encodes the pore-forming subunit of the potassium channel responsible for a fast component of the cardiac delayed rectifier potassium current (IKr). Potassium 91-100 ETS transcription factor ERG Homo sapiens 38-42 33450182-4 2021 However, the drug inhibition mechanism remains unclear because of the scarce structural information regarding the drug- and potassium-bound hERG channels. Potassium 124-133 ETS transcription factor ERG Homo sapiens 140-144 33450182-5 2021 In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3.5-A resolution. Potassium 54-63 ETS transcription factor ERG Homo sapiens 70-74 33450182-5 2021 In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3.5-A resolution. Potassium 54-63 ETS transcription factor ERG Homo sapiens 123-127 33437379-4 2020 Potassium currents were recorded by whole-cell patch clamping in HEK293 cells transiently transfected with wild-type and/or mutant hERG potassium channel. Potassium 0-9 ETS transcription factor ERG Homo sapiens 131-135 32253972-2 2020 A frequent cause for LQTS are mutations in the KCNH2 gene (also known as the human ether-a-go-go-related gene or hERG), which reduce or modulate the potassium current IKr and hence alter cardiac repolarization. Potassium 149-158 ETS transcription factor ERG Homo sapiens 113-117 32888379-4 2021 Computer calculations were performed using pharmacokinetic and pharmacodynamic data, including affinity to block the rapid component of the delayed rectifier cardiac potassium current (IKr ) encoded by the human ether-a-go-go gene (hERG), propensity to prolong cardiac repolarization (QT interval) and cause torsade de pointes (TdP). Potassium 166-175 ETS transcription factor ERG Homo sapiens 232-236 32882214-2 2020 Although a previous report showed that quetiapine blocked hERG potassium current, quetiapine has been considered relatively safe in terms of cardiovascular side effects. Potassium 63-72 ETS transcription factor ERG Homo sapiens 58-62 32999428-6 2020 CBD inhibited hERG potassium channels with an IC50 value of 2.07 microM at room temperature and delayed rectifier potassium current with 6.5 microM at 37 C, respectively. Potassium 19-28 ETS transcription factor ERG Homo sapiens 14-18 31598634-10 2020 CONCLUSION: We demonstrated a high vulnerability to tachycardia of optically tachypaced hiPSC-CMs in EHT and the effective termination by ryanodine receptor stabilization, sodium or hERG potassium channel inhibition. Potassium 187-196 ETS transcription factor ERG Homo sapiens 182-186 32703555-0 2020 Inhibition of Human Ether-A-Go-Go-Related Gene (hERG) Potassium Current by the Novel Sotalol Analogue, Soestalol. Potassium 54-63 ETS transcription factor ERG Homo sapiens 48-52 32703555-3 2020 Their hypothesis was that soestalol, but not the acid metabolite, would inhibit the hERG potassium current. Potassium 89-98 ETS transcription factor ERG Homo sapiens 84-88 31557540-1 2020 BACKGROUND: KCNH2 encodes the human ether-a-go-go-related gene (hERG) potassium channel, which passes the rapid delayed rectifier potassium current, IKr. Potassium 70-79 ETS transcription factor ERG Homo sapiens 64-68 31935579-3 2020 Aim of this work is to assess the effect of four drugs blocking the human ether-a-go-go-related gene (hERG) potassium channel, alone or in combination with other ionic channel blocks, on SHVR, as estimated by the V-index on short triplicate 10 s ECG. Potassium 108-117 ETS transcription factor ERG Homo sapiens 102-106 31557540-1 2020 BACKGROUND: KCNH2 encodes the human ether-a-go-go-related gene (hERG) potassium channel, which passes the rapid delayed rectifier potassium current, IKr. Potassium 130-139 ETS transcription factor ERG Homo sapiens 64-68 31810890-1 2020 Analogues of the anti-tuberculosis drug bedaquiline, bearing a 3,5-dimethoxy-4-pyridyl C-unit, retain high anti-bacterial potency yet exert less inhibition of the hERG potassium channel, in vitro, than the parent compound. Potassium 168-177 ETS transcription factor ERG Homo sapiens 163-167 31919307-8 2020 Three target proteins, i.e. human ether-a-go-go-related (hERG) potassium channel, the inhibitor of apoptosis protein 3 and serine/threonine-protein kinase PIM1, were chosen as the targets. Potassium 63-72 ETS transcription factor ERG Homo sapiens 57-61 31882846-1 2019 The hERG potassium channel influences ventricular action potential duration. Potassium 9-18 ETS transcription factor ERG Homo sapiens 4-8 31657676-1 2020 The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (IKr), which is a crucial determinant of cardiac repolarization. Potassium 44-53 ETS transcription factor ERG Homo sapiens 38-42 31657676-1 2020 The human ether-a-go-go-related gene (hERG) potassium channel is the rapidly activating component of cardiac delayed rectifier potassium current (IKr), which is a crucial determinant of cardiac repolarization. Potassium 127-136 ETS transcription factor ERG Homo sapiens 38-42 31730936-4 2020 This emphasizes the pharmacologic properties necessary for TdP but does not account for situations where clinical exposure may be higher, or where hERG potassium channel active metabolites are involved. Potassium 152-161 ETS transcription factor ERG Homo sapiens 147-151 31621014-2 2019 Interference with the hERG potassium ion channel may cause cardiac arrhythmia and can even lead to death. Potassium 27-36 ETS transcription factor ERG Homo sapiens 22-26 31347753-3 2019 This study proposes an artificial neural network (ANN) for noninvasive electrocardiography-based classification of the hERG potassium-channel block. Potassium 124-133 ETS transcription factor ERG Homo sapiens 119-123 31659098-1 2019 BACKGROUND/AIM: hERG potassium channels enhance tumor invasiveness and breast cancer proliferation. Potassium 21-30 ETS transcription factor ERG Homo sapiens 16-20 31017964-6 2019 The changes in protein expression were associated with ~50% decrease in hERG potassium conductance. Potassium 77-86 ETS transcription factor ERG Homo sapiens 72-76 31526813-6 2019 Effects of reference compounds were in accordance with the literature, indicating the presence of hERG potassium (dofetilide), sodium (mexiletine) and calcium (nifedipine) channels and alpha-adrenergic receptors (isoproterenol). Potassium 103-112 ETS transcription factor ERG Homo sapiens 98-102 30792104-2 2019 Additionally, inhibition of potassium current through the cardiac hERG channel by bedaquiline, is associated with prolongation of the QT interval, necessitating cardiovascular monitoring. Potassium 28-37 ETS transcription factor ERG Homo sapiens 66-70 29617054-0 2018 Activation of voltage-gated sodium current and inhibition of erg-mediated potassium current caused by telmisartan, an antagonist of angiotensin II type-1 receptor, in HL-1 atrial cardiomyocytes. Potassium 74-83 ETS transcription factor ERG Homo sapiens 61-64 29806042-2 2018 Even newly released anti-arrhythmic drugs, like ivabradine with HCN channel as a primary target, block the hERG potassium current in overlapping concentration interval. Potassium 112-121 ETS transcription factor ERG Homo sapiens 107-111 28556923-2 2017 However, ivabradine also inhibits human ether-a-go-go (hERG) mediated potassium currents. Potassium 70-79 ETS transcription factor ERG Homo sapiens 55-59 29305421-2 2018 The fast component of the delayed rectifier potassium currents responsible for repolarization of the cardiac action potential, Ikr, is encoded by the human ether-a-go-go related gene (hERG) channel. Potassium 44-53 ETS transcription factor ERG Homo sapiens 184-188 26689773-10 2016 Prolongation of ventricular APD and QT interval is related to the inhibition of multiple repolarization potassium currents, especially hERG channels. Potassium 104-113 ETS transcription factor ERG Homo sapiens 135-139 28097003-6 2016 System-specific maximal achievable Delta QTc was estimated to 28% from baseline in both dog and human, while %hERG block leading to half-maximal effects was 58% lower in human, suggesting a higher contribution of hERG-mediated potassium current to cardiac repolarization. Potassium 227-236 ETS transcription factor ERG Homo sapiens 213-217