PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21514354-9 2011 Changes in hepatic CYP2B6 and CYP2C19 content had more of an influence on cholinesterase inhibition for exposures to chlorpyrifos than parathion, which agrees with previously reported literature that these CYPs are more reaction biased for desulfurization (activation) and dearylation (detoxification) of chlorpyrifos compared to parathion. Parathion 135-144 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 19-25 21514354-2 2011 Phosphororthioate OPs like chlorpyrifos and parathion are directly activated and detoxified by various cytochrome P450s (CYPs), with the primary CYPs involved being CYP2B6 and CYP2C19. Parathion 44-53 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 165-171 21514354-9 2011 Changes in hepatic CYP2B6 and CYP2C19 content had more of an influence on cholinesterase inhibition for exposures to chlorpyrifos than parathion, which agrees with previously reported literature that these CYPs are more reaction biased for desulfurization (activation) and dearylation (detoxification) of chlorpyrifos compared to parathion. Parathion 330-339 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 19-25 27441453-6 2016 Using menadione as the redox-cycling chemical, we discovered that this enzymatic reaction blocks metabolic activation of parathion in rat and human liver microsomes and in recombinant CYPs important to parathion metabolism, including CYP1A2, CYP2B6, and CYP3A4. Parathion 121-130 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 242-248 17079358-0 2007 Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos. Parathion 53-62 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 25-29