PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30771617-7	2019	The combination treatment markedly attenuated the deoxyribonucleoside triphosphate (dNTP) pools by downregulating the mRNA expression of RRM1 and RRM2 through E2F1.	Parathion	84-88	ribonucleotide reductase catalytic subunit M1	Homo sapiens	137-141	
25375241-1	2014	Ribonucleotide reductase (RNR) enzyme is composed of the homodimeric RRM1 and RRM2 subunits, which together form a heterotetramic active enzyme that catalyzes the de novo reduction of ribonucleotides to generate deoxyribonucleotides (dNTPs), which are required for DNA replication and DNA repair processes.	Parathion	234-239	ribonucleotide reductase catalytic subunit M1	Homo sapiens	69-73	
26092210-1	2015	PURPOSE: RRM1 is the large subunit of ribonucleotide reductase (RNR), which catalyzes the rate-limiting step in the production of deoxyribonucleotides (dNTPs) and is essential for DNA synthesis and repair.	Parathion	152-157	ribonucleotide reductase catalytic subunit M1	Homo sapiens	9-13	
24197132-3	2014	Ribonucleotide reductase (RNR), containing regulatory hRRM1 and catalytic hRRM2 subunits, is the enzyme that catalyzes the conversion of ribonucleoside diphosphates (NDP) to deoxyribonucleoside diphosphates (dNDP) and thereby provides dNTP precursors needed for the synthesis of DNA.	Parathion	235-239	ribonucleotide reductase catalytic subunit M1	Homo sapiens	54-59	
24614341-1	2014	Ribonucleotide reductase M1 (RRM1) is required for mammalian deoxyribonucleotide (dNTP) metabolism.	Parathion	82-86	ribonucleotide reductase catalytic subunit M1	Homo sapiens	0-27	
24614341-1	2014	Ribonucleotide reductase M1 (RRM1) is required for mammalian deoxyribonucleotide (dNTP) metabolism.	Parathion	82-86	ribonucleotide reductase catalytic subunit M1	Homo sapiens	29-33	
21336276-1	2011	Ribonucleotide reductase (RR) is an alpha(n)beta(n) (RR1-RR2) complex that maintains balanced dNTP pools by reducing NDPs to dNDPs.	Parathion	94-98	ribonucleotide reductase catalytic subunit M1	Homo sapiens	53-60	
23922955-11	2013	Furthermore, inhibition of RRM1 by siRNA significantly reduced the dNTP pool, Ras/Raf and MMP-9 activities and the levels of p-MEK, p-ERK and NF-kappaB, resulting in growth retardation and reduced invasion in AGS and NCI-N87 cells.	Parathion	67-71	ribonucleotide reductase catalytic subunit M1	Homo sapiens	27-31	
12221087-5	2002	We observed that constitutively active RB attenuates the expression of specific dNTP synthetic enzymes: dihydrofolate reductase, ribonucleotide reductase (RNR) subunits R1/R2, and thymidylate synthase (TS).	Parathion	80-84	ribonucleotide reductase catalytic subunit M1	Homo sapiens	169-174	
21566726-1	2009	The dNTP supply system genes RRM1, DCTD, TYMS, TK1 and DCK balance dNTP pools to avoid incorrect insertions of bases (i.e. DNA mismatches) and the DNA mismatch repair system genes MLH1 and MSH2 are involved in removing such mismatches.	Parathion	4-8	ribonucleotide reductase catalytic subunit M1	Homo sapiens	29-33	
21566726-1	2009	The dNTP supply system genes RRM1, DCTD, TYMS, TK1 and DCK balance dNTP pools to avoid incorrect insertions of bases (i.e. DNA mismatches) and the DNA mismatch repair system genes MLH1 and MSH2 are involved in removing such mismatches.	Parathion	67-71	ribonucleotide reductase catalytic subunit M1	Homo sapiens	29-33