PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28373537-0	2017	Structure-metabolism relationships in human-AOX: Chemical insights from a large database of aza-aromatic and amide compounds.	Azathioprine	92-95	aldehyde oxidase 1	Homo sapiens	44-47	
22495427-4	2012	RESULTS: AOX1 rs55754655 variant allele carriers received a higher mean AZA dose 3, 6, and 12 months after transplantation (P < 0.05).	Azathioprine	72-75	aldehyde oxidase 1	Homo sapiens	9-13	
26876431-7	2016	For the introduction of aldehyde oxidase (AOX) into clinical practice, the association between AOX activity and AZA dose requirements should be positively confirmed.	Azathioprine	112-115	aldehyde oxidase 1	Homo sapiens	42-45	
26876431-7	2016	For the introduction of aldehyde oxidase (AOX) into clinical practice, the association between AOX activity and AZA dose requirements should be positively confirmed.	Azathioprine	112-115	aldehyde oxidase 1	Homo sapiens	95-98	
26876431-7	2016	For the introduction of aldehyde oxidase (AOX) into clinical practice, the association between AOX activity and AZA dose requirements should be positively confirmed.	Azathioprine	112-115	aldehyde oxidase 1	Homo sapiens	24-40	
22495427-0	2012	Polymorphism of genes involved in purine metabolism (XDH, AOX1, MOCOS) in kidney transplant recipients receiving azathioprine.	Azathioprine	113-125	aldehyde oxidase 1	Homo sapiens	58-62	
22495427-9	2012	However, if the observed association between SNPs: AOX1 rs55754655, MOCOS rs594445, and AZA dose requirements would be positively confirmed in further independent studies, it could be introduced into clinical practice to individualize thiopurine treatment.	Azathioprine	88-91	aldehyde oxidase 1	Homo sapiens	51-55	
22279051-3	2012	AO has an important role in the metabolism of drugs based on its broad substrate specificity oxidizing aromatic aza-heterocycles, for example, N(1)-methylnicotinamide and N-methylphthalazinium, or aldehydes, such as benzaldehyde, retinal, and vanillin.	Azathioprine	112-115	aldehyde oxidase 1	Homo sapiens	0-2	
35118815-12	2022	In conclusion, among patients who were TPMT and NUDT15 normal metabolizers, a score combining the predicted expression of AOX1 and NME1 was associated with an increased risk for discontinuing azathioprine due to myelotoxicity.	Azathioprine	192-204	aldehyde oxidase 1	Homo sapiens	122-126	
19500084-3	2009	Xanthine oxidase/dehydrogenase (XDH) and aldehyde oxidase (AO) compete with TPMT to inactivate AZA.	Azathioprine	95-98	aldehyde oxidase 1	Homo sapiens	41-57	
19500084-3	2009	Xanthine oxidase/dehydrogenase (XDH) and aldehyde oxidase (AO) compete with TPMT to inactivate AZA.	Azathioprine	95-98	aldehyde oxidase 1	Homo sapiens	59-61	
19500084-4	2009	AIM: To assess whether genetic polymorphism in AOX1, XDH and MOCOS (the product of which activates the essential cofactor for AO and XDH) is associated with AZA treatment outcome in IBD.	Azathioprine	157-160	aldehyde oxidase 1	Homo sapiens	47-51	
19500084-4	2009	AIM: To assess whether genetic polymorphism in AOX1, XDH and MOCOS (the product of which activates the essential cofactor for AO and XDH) is associated with AZA treatment outcome in IBD.	Azathioprine	157-160	aldehyde oxidase 1	Homo sapiens	47-49	
19500084-6	2009	RESULTS: Single nucleotide polymorphism AOX1 c.3404A > G (Asn1135Ser, rs55754655) predicted lack of AZA response (P = 0.035, OR 2.54, 95%CI 1.06-6.13) and when combined with TPMT activity, this information allowed stratification of a patient"s chance of AZA response, ranging from 86% in patients where both markers were favourable to 33% where they were unfavourable (P < 0.0001).	Azathioprine	103-106	aldehyde oxidase 1	Homo sapiens	40-44	
19500084-6	2009	RESULTS: Single nucleotide polymorphism AOX1 c.3404A > G (Asn1135Ser, rs55754655) predicted lack of AZA response (P = 0.035, OR 2.54, 95%CI 1.06-6.13) and when combined with TPMT activity, this information allowed stratification of a patient"s chance of AZA response, ranging from 86% in patients where both markers were favourable to 33% where they were unfavourable (P < 0.0001).	Azathioprine	257-260	aldehyde oxidase 1	Homo sapiens	40-44