PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33821842-0 2021 Pretreatment HLADQA1-HLADRB1 Testing for the Prevention of Azathioprine-Induced Pancreatitis in Inflammatory Bowel Disease: A Prospective Cohort Study. Azathioprine 59-71 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 13-28 33821842-2 2021 The haplotype HLADQA1-HLADRB1*07:01A>C is strongly associated with azathioprine-induced pancreatitis in IBD. Azathioprine 67-79 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 14-21 33821842-3 2021 We aimed to evaluate whether pretreatment HLADQA1-HLADRB1*07:01A>C screening will reduce the risk of azathioprine-induced pancreatitis. Azathioprine 101-113 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 42-49 33821842-7 2021 RESULTS: HLADQA1-HLADRB1*07:01A>C screening resulted in an 11-fold reduction in the incidence of azathioprine-induced pancreatitis (n = 1/328 or 0.30% vs n = 13/373 or 3.4%). Azathioprine 97-109 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 9-16 33821842-10 2021 DISCUSSION: HLADQA1-HLADRB1*07:01A>C screening reduced the risk of azathioprine-induced pancreatitis; however, using this strategy to guide the use of azathioprine therapy in IBD may eliminate a large proportion of patients from being eligible for treatment with azathioprine. Azathioprine 67-79 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 12-19 33821842-10 2021 DISCUSSION: HLADQA1-HLADRB1*07:01A>C screening reduced the risk of azathioprine-induced pancreatitis; however, using this strategy to guide the use of azathioprine therapy in IBD may eliminate a large proportion of patients from being eligible for treatment with azathioprine. Azathioprine 151-163 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 12-19 33821842-10 2021 DISCUSSION: HLADQA1-HLADRB1*07:01A>C screening reduced the risk of azathioprine-induced pancreatitis; however, using this strategy to guide the use of azathioprine therapy in IBD may eliminate a large proportion of patients from being eligible for treatment with azathioprine. Azathioprine 151-163 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 12-19 33821842-11 2021 In regions where there is access to other IBD therapies, and given the short-term and long-term toxicities associated with azathioprine, HLADQA1-HLADRB1*07:01A>C-screening may be a clinically relevant strategy for enhancing the safe use of azathioprine in IBD. Azathioprine 123-135 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 137-144 33821842-11 2021 In regions where there is access to other IBD therapies, and given the short-term and long-term toxicities associated with azathioprine, HLADQA1-HLADRB1*07:01A>C-screening may be a clinically relevant strategy for enhancing the safe use of azathioprine in IBD. Azathioprine 240-252 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 137-144 35120281-8 2022 We conclude that HLA-DQA1*02:01-HLA-DRB1*07:01 is a marker for increased risk of acute pancreatitis in individuals of Swedish genetic origin, treated with azathioprine for Crohn"s disease. Azathioprine 155-167 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 17-25 29270995-0 2018 HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease. Azathioprine 55-67 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 0-17