PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33950972-0 2021 Azathioprine-induced toxoplasma gondii infection in a patient with Crohn"s disease with NUDT15 variation: A case report. Azathioprine 0-12 nudix hydrolase 15 Homo sapiens 88-94 33950972-3 2021 Most of the previous literature focused on the TPMP gene-related adverse reactions, herein, we report a case of Crohn"s disease patient with nucleoside diphosphate-linked moiety X motif 15 gene (NUDT15) variation and wild-type TPMP gene who developed toxoplasma gondii infection after azathioprine treatment. Azathioprine 285-297 nudix hydrolase 15 Homo sapiens 195-201 33950972-9 2021 CONCLUSION: We report a case of Crohn"s disease in a patient who developed severe pneumonia caused by toxoplasma gondii infection due to the administration of AZA, with normal TPMP gene but NUDT15 gene mutation. Azathioprine 159-162 nudix hydrolase 15 Homo sapiens 190-196 33950972-10 2021 This indicates that NUDT15 variation may contribute to severe adverse events in patients treated with azathioprine, and we suggest that NUDT15 genotype be detected before the use of azathioprine in order to provide personalized therapy and reduce side effects. Azathioprine 102-114 nudix hydrolase 15 Homo sapiens 20-26 32713039-0 2020 Complete remission of refractory pemphigus vulgaris in a Chinese patient with mutated NUDT15 by combination of minimal doses of azathioprine and prednisone. Azathioprine 128-140 nudix hydrolase 15 Homo sapiens 86-92 33707905-6 2021 In this report, we highlight a case of serious hematological toxicity associated with azathioprine use in a patient with Crohn"s disease with homozygous NUDT 15 variant, thus favoring the implementation of a pharmacogenomic approach before starting azathioprine, particularly in the Asian population. Azathioprine 86-98 nudix hydrolase 15 Homo sapiens 153-160 33707905-6 2021 In this report, we highlight a case of serious hematological toxicity associated with azathioprine use in a patient with Crohn"s disease with homozygous NUDT 15 variant, thus favoring the implementation of a pharmacogenomic approach before starting azathioprine, particularly in the Asian population. Azathioprine 249-261 nudix hydrolase 15 Homo sapiens 153-160 32617765-6 2021 Variants in two genes, TPMT and NUDT15, are widely recognized, leading drug regulatory agencies and professional organizations to adopt recommendations for testing before initiation of azathioprine therapy. Azathioprine 185-197 nudix hydrolase 15 Homo sapiens 32-38 32617765-10 2021 Azathioprine is a success story for the clinical implementation of pharmacogenomics, particularly the effects of TPMT and NUDT15 variants on myelosuppression. Azathioprine 0-12 nudix hydrolase 15 Homo sapiens 122-128 33111378-0 2020 NUDT15 C415T variant compared with TPMT genotyping in predicting azathioprine-induced leucopenia: prospective analysis of 1014 inflammatory bowel disease patients in India. Azathioprine 65-77 nudix hydrolase 15 Homo sapiens 0-6 33111378-14 2020 CONCLUSION: NUDT15 variant genotyping appears to be a better predictor for azathioprine-induced leucopenia in an Indian population than TPMT with high accuracy and can be useful in optimizing azathioprine dosage. Azathioprine 75-87 nudix hydrolase 15 Homo sapiens 12-18 33111378-14 2020 CONCLUSION: NUDT15 variant genotyping appears to be a better predictor for azathioprine-induced leucopenia in an Indian population than TPMT with high accuracy and can be useful in optimizing azathioprine dosage. Azathioprine 192-204 nudix hydrolase 15 Homo sapiens 12-18 33860754-0 2021 Importance of NUDT15 c.415C>T phenotype in treatment of inflammatory bowel disease with azathioprine and occurrence of severe myelosuppression: A case report. Azathioprine 88-100 nudix hydrolase 15 Homo sapiens 14-20 33860754-5 2021 In this case, the azathioprine-related genotyping test showed that homozygous wild-type TPMT*3 but a c.415C>T homozygous mutation was found in NUDT15. Azathioprine 18-30 nudix hydrolase 15 Homo sapiens 143-149 33846471-0 2021 Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis. Azathioprine 63-75 nudix hydrolase 15 Homo sapiens 51-57 33846471-1 2021 This study aimed to investigate the influence of TPMT*3C, ITPA, NUDT15, and 6-thioguanine nucleotides (6-TGN) on azathioprine (AZA)-induced myelosuppression in Southwest China patients with autoimmune hepatitis (AIH). Azathioprine 113-125 nudix hydrolase 15 Homo sapiens 64-70 33846471-10 2021 This study confirmed that NUDT15 variants are a potential independent risk predictor for AZA-induced leukopenia and neutropenia. Azathioprine 89-92 nudix hydrolase 15 Homo sapiens 26-32 32713039-1 2020 While azathioprine (AZA) combined with corticosteroids remains the first-line therapy to treat patients with pemphigus vulgaris (PV), there are increasing reports of AZA-induced leukopenia, which provides the rationale for monitoring the blood cell count and testing the genotypes at the thiopurine methyltransferase (TPMT) and the nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) genes. Azathioprine 166-169 nudix hydrolase 15 Homo sapiens 332-384 32713039-1 2020 While azathioprine (AZA) combined with corticosteroids remains the first-line therapy to treat patients with pemphigus vulgaris (PV), there are increasing reports of AZA-induced leukopenia, which provides the rationale for monitoring the blood cell count and testing the genotypes at the thiopurine methyltransferase (TPMT) and the nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) genes. Azathioprine 166-169 nudix hydrolase 15 Homo sapiens 386-392 32842934-6 2022 DISCUSSION: NUDT15 R139C mutation can be used as a predictive factor for AZA-induced leukopenia in both European and Asian populations. Azathioprine 73-76 nudix hydrolase 15 Homo sapiens 12-18 32827393-0 2020 NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series. Azathioprine 49-61 nudix hydrolase 15 Homo sapiens 0-6 30843183-0 2019 NUDT15 polymorphism identified in a patient with azathioprine hypersensitivity syndrome presenting as erythema nodosum and hepatotoxicity. Azathioprine 49-61 nudix hydrolase 15 Homo sapiens 0-6 32598049-0 2020 Adjustment of azathioprine dose should be based on a lower 6-TGN target level to avoid leucopenia in NUDT15 intermediate metabolizers. Azathioprine 14-26 nudix hydrolase 15 Homo sapiens 101-107 32598049-2 2020 AIM: To investigate the association between NUDT15 polymorphisms and time-to-leucopenia in paediatric patients with inflammatory bowel disease (IBD) receiving azathioprine and to determine the relationship between NUDT15 polymorphisms and 6-thioguanine nucleotide (6-TGN) levels. Azathioprine 159-171 nudix hydrolase 15 Homo sapiens 44-50 32598049-11 2020 CONCLUSION: NUDT15 polymorphisms were associated with time-to-leucopenia during azathioprine treatment in Korean paediatric patients with IBD. Azathioprine 80-92 nudix hydrolase 15 Homo sapiens 12-18 33442476-0 2020 NUDT15 genotyping during azathioprine treatment in patients with inflammatory bowel disease: implications for a dose-optimization strategy. Azathioprine 25-37 nudix hydrolase 15 Homo sapiens 0-6 33442476-1 2020 Background: NUDT15 R139C is an Asian-prevalent genetic variant related to azathioprine (AZA) intolerance in patients with inflammatory bowel disease (IBD). Azathioprine 74-86 nudix hydrolase 15 Homo sapiens 12-18 33442476-1 2020 Background: NUDT15 R139C is an Asian-prevalent genetic variant related to azathioprine (AZA) intolerance in patients with inflammatory bowel disease (IBD). Azathioprine 88-91 nudix hydrolase 15 Homo sapiens 12-18 31744310-0 2020 First Case of Azathioprine-Induced Severe Hematotoxicity in a Tunisian Patient With Homozygous TT for NUDT15 rs116855232. Azathioprine 14-26 nudix hydrolase 15 Homo sapiens 102-108 32187056-0 2020 Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease. Azathioprine 76-88 nudix hydrolase 15 Homo sapiens 50-56 32062783-6 2020 The aim of our study was to determine the contribution of NUDT15 mutations in azathioprine-induced neutropenia in Han Chinese patients with dermatologic diseases. Azathioprine 78-90 nudix hydrolase 15 Homo sapiens 58-64 32062783-16 2020 CONCLUSIONS: Pretreatment screening of NUDT15 might reduce the chance of azathioprine-induced neutropenia in Han Chinese patients with dermatologic diseases. Azathioprine 73-85 nudix hydrolase 15 Homo sapiens 39-45 31556692-0 2019 NUDT15 and TPMT Genetic Polymorphisms Are Related to Azathioprine Intolerance in Chinese Patients with Rheumatic Diseases. Azathioprine 53-65 nudix hydrolase 15 Homo sapiens 0-6 31556692-5 2019 Results: The TPMT*3C and NUDT15*3 genotypes were significantly associated with AZA-induced leukopenia (p = 0.007 and 4.475 x 10-6, respectively). Azathioprine 79-82 nudix hydrolase 15 Homo sapiens 25-31 31556692-9 2019 Conclusion: This study demonstrated that NUDT15*3 and TPMT*3C are both highly predictive genetic markers for AZA-induced toxicity in Chinese populations with rheumatic diseases. Azathioprine 109-112 nudix hydrolase 15 Homo sapiens 41-47 30035323-0 2019 Azathioprine-induced myelosuppression in two pemphigus vulgaris patients with homozygous polymorphism of NUDT15. Azathioprine 0-12 nudix hydrolase 15 Homo sapiens 105-111 30742971-0 2019 Novel multiple heterozygous NUDT15 variants cause an azathioprine-induced severe leukopenia in a patient with systemic lupus erythematosus. Azathioprine 53-65 nudix hydrolase 15 Homo sapiens 28-34 31024313-1 2019 The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. Azathioprine 116-128 nudix hydrolase 15 Homo sapiens 58-64 31024313-1 2019 The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. Azathioprine 130-133 nudix hydrolase 15 Homo sapiens 58-64 31024313-10 2019 Adjusting the AZA dosage should be considered in patients according to the NUDT15 R139C genotypes. Azathioprine 14-17 nudix hydrolase 15 Homo sapiens 75-81 30577288-0 2018 Azathioprine-induced Agranulocytosis and Severe Alopecia After Kidney Transplantation Associated With a NUDT15 Polymorphism: A Case Report. Azathioprine 0-12 nudix hydrolase 15 Homo sapiens 104-110 30577288-4 2018 Genetic testing revealed a homozygous polymorphism of NUDT15 (rs116855232, NM_018283.3:c.415C>T: p.Arg139Cys), which has previously been identified as a risk factor for AZA-related complications in patients with inflammatory bowel disease. Azathioprine 172-175 nudix hydrolase 15 Homo sapiens 54-60 30577288-5 2018 CONCLUSION: Genetic screening for NUDT15 could contribute to the prevention of serious adverse reactions to AZA and provide the opportunity for personalized medicine. Azathioprine 108-111 nudix hydrolase 15 Homo sapiens 34-40 28566182-0 2017 NUDT15 p.R139C variant is common and strongly associated with azathioprine-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases. Azathioprine 62-74 nudix hydrolase 15 Homo sapiens 0-6 30106365-14 2018 Therefore, we analyzed three AZA metabolism-associated genes for mutations: thiopurine S-methyltransferase (TPMT), inosine triphosphate pyrophosphohydrolase (ITPA), and nucleoside diphosphate linked moiety X-type motif 15 (NUDT15), and we identified ITPA 94C>A mutation. Azathioprine 29-32 nudix hydrolase 15 Homo sapiens 223-229 29704867-0 2018 Azathioprine-induced alopecia and leukopenia associated with NUDT15 polymorphisms. Azathioprine 0-12 nudix hydrolase 15 Homo sapiens 61-67 30101994-2 2018 We tried to see whether NUDT15 gene polymorphism can be the most susceptible genetic factor for AZA toxicity and the gene screening is beneficial to avoid the adverse events of AZA for the treatment of skin diseases. Azathioprine 177-180 nudix hydrolase 15 Homo sapiens 24-30 29867468-0 2018 NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients. Azathioprine 43-55 nudix hydrolase 15 Homo sapiens 0-6 29867468-1 2018 The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. Azathioprine 124-136 nudix hydrolase 15 Homo sapiens 58-64 29867468-1 2018 The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. Azathioprine 138-141 nudix hydrolase 15 Homo sapiens 58-64 29867468-7 2018 Therefore, the variant of NUDT15 R139C is strongly associated with AZA-induced leukopenia in Chinese patients with various autoimmune diseases such as systemic lupus erythematosus, Sjogren"s syndrome, etc. Azathioprine 67-70 nudix hydrolase 15 Homo sapiens 26-32 29702976-0 2018 NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review. Azathioprine 45-57 nudix hydrolase 15 Homo sapiens 0-6 29702976-3 2018 Recent studies found that NUDT15 R139C polymorphism is strongly associated with AZA-induced leukopenia in Koreans. Azathioprine 80-83 nudix hydrolase 15 Homo sapiens 26-32 29702976-5 2018 Here, we report a case of a Chinese patient with Sjogren syndrome (SS) with wild-type TPMT*3C who was diagnosed with AZA-induced severe toxicity due to NUDT15 mutation based on clinical and laboratory characteristics. Azathioprine 117-120 nudix hydrolase 15 Homo sapiens 152-158 29702976-10 2018 CONCLUSION: In this report, we first provide detailed clinical and laboratory characteristics of AZA-induced leukopenia in a patient with SS with a mutant NUDT15 R139C genotype (TT allele) and normal TPMT activity. Azathioprine 97-100 nudix hydrolase 15 Homo sapiens 155-161 30101994-2 2018 We tried to see whether NUDT15 gene polymorphism can be the most susceptible genetic factor for AZA toxicity and the gene screening is beneficial to avoid the adverse events of AZA for the treatment of skin diseases. Azathioprine 96-99 nudix hydrolase 15 Homo sapiens 24-30 29491687-9 2018 There were 44 patients (20.1%) with mutant genotype of NUDT15 (C/T); among them, 16 received AZA, and 8 (50%) developed leukopenia. Azathioprine 93-96 nudix hydrolase 15 Homo sapiens 55-61 29491687-10 2018 There were 175 patients (79.7%) with wild genotype of NUDT15 (C/C); among them, 64 received AZA, and 11 (17.2%) developed leukopenia. Azathioprine 92-95 nudix hydrolase 15 Homo sapiens 54-60 29491687-15 2018 Therefore, NUDT15 gene polymorphism was obviously a better biomarker than TPMT gene polymorphism in the prediction of AZA-induced leukopenia. Azathioprine 118-121 nudix hydrolase 15 Homo sapiens 11-17 29491687-17 2018 NUDT15 polymorphism is a better predictor for AZA-induced leukopenia than TPMT polymorphism. Azathioprine 46-49 nudix hydrolase 15 Homo sapiens 0-6 28566182-2 2017 In addition to variation in TPMT (thiopurine S-methyltransferase), the NUDT15 p.R139C variant was recently identified to have a strong association with AZA-induced leukopenia. Azathioprine 152-155 nudix hydrolase 15 Homo sapiens 71-77 28566182-10 2017 Therefore, the NUDT15 p.R139C variant is common and strongly associated with AZA-induced early leukopenia and severe alopecia in Korean patients with various neurological diseases. Azathioprine 77-80 nudix hydrolase 15 Homo sapiens 15-21 34866237-0 2022 Effect of NUDT15 polymorphisms on early hematological safety of low-dose azathioprine in Chinese patients with pemphigus vulgaris: A prospective cohort study. Azathioprine 73-85 nudix hydrolase 15 Homo sapiens 10-16 28670229-8 2017 However, NUDT15 p.Arg139Cys was significantly associated with the interval between initiation and discontinuation of AZA among patients with gastrointestinal intolerance. Azathioprine 117-120 nudix hydrolase 15 Homo sapiens 9-15 27381176-0 2016 Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report. Azathioprine 84-96 nudix hydrolase 15 Homo sapiens 44-50 27381176-7 2016 We report the first case of a Chinese patient with AZA-induced severe toxicity with no clinically significant TPMT variant but with the NUDT15 c.415C>T allele. Azathioprine 51-54 nudix hydrolase 15 Homo sapiens 136-142 27381176-12 2016 WHAT IS NEW AND CONCLUSION: NUDT15 c.415C>T may be another predictor of AZA-induced leukocytopenia. Azathioprine 75-78 nudix hydrolase 15 Homo sapiens 28-34 34582038-0 2022 TPMT and NUDT15 Variants Predict Discontinuation of Azathioprine for Myelotoxicity in Patients with Inflammatory Disease: Real-World Clinical Results. Azathioprine 52-64 nudix hydrolase 15 Homo sapiens 9-15 34582038-3 2022 Thiopurine-S-methyltransferase (TPMT) and nudix hydrolase-15 (NUDT15) are enzymes involved in azathioprine metabolism; variants in the genes encoding these enzymes increase the risk for azathioprine myelotoxicity. Azathioprine 94-106 nudix hydrolase 15 Homo sapiens 62-68 34582038-3 2022 Thiopurine-S-methyltransferase (TPMT) and nudix hydrolase-15 (NUDT15) are enzymes involved in azathioprine metabolism; variants in the genes encoding these enzymes increase the risk for azathioprine myelotoxicity. Azathioprine 186-198 nudix hydrolase 15 Homo sapiens 62-68 34582038-6 2022 We hypothesized that in patients with inflammatory diseases, TPMT and NUDT15 genotype data predict the risk of discontinuing azathioprine due to myelotoxicity. Azathioprine 125-137 nudix hydrolase 15 Homo sapiens 70-76 34582038-14 2022 In conclusion, TPMT and NUDT15 metabolizer status predicts discontinuation due to myelotoxicity for patients taking azathioprine for inflammatory conditions. Azathioprine 116-128 nudix hydrolase 15 Homo sapiens 24-30 26735160-12 2016 Three patients with the NUDT15 heterozygous variant are currently treated with AZA at a dose of 0.76 mg/kg/day. Azathioprine 79-82 nudix hydrolase 15 Homo sapiens 24-30 26935390-9 2016 Interestingly, recent genome-wide association studies have shown that, for both azathioprine in inflammatory bowel disease and mercaptopurine in acute lymphoblastic leukemia, treatment effects on patients" white blood cells are related to variants of a gene, NUDT15, involved in biotransformation of oxidated nucleotides. Azathioprine 80-92 nudix hydrolase 15 Homo sapiens 259-265 34866237-3 2022 To investigate hematological AE of low-dose AZA based on NUDT15 genotypes among patients with PV, a prospective cohort study was conducted in patients with PV, followed-up for the first 8 weeks after AZA administration. Azathioprine 44-47 nudix hydrolase 15 Homo sapiens 57-63 34866237-10 2022 Low-dose AZA based on NUDT15 genotypes can reduce the risk of early hematological AE among patients with PV. Azathioprine 9-12 nudix hydrolase 15 Homo sapiens 22-28 35118815-1 2022 TPMT and NUDT15 variants explain less than 25% of azathioprine-associated myelotoxicity. Azathioprine 50-62 nudix hydrolase 15 Homo sapiens 9-15 34466252-0 2021 Azathioprine-induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report. Azathioprine 0-12 nudix hydrolase 15 Homo sapiens 141-147 34466252-1 2021 This report highlights azathioprine-induced severe myelosuppression in the patient with NUDT15 minor variant. Azathioprine 23-35 nudix hydrolase 15 Homo sapiens 88-94 34430579-1 2021 Background: This study aimed to analyze the cost-effectiveness of combining screening for thiopurine methyl transferase (TPMT) and nucleotide triphosphate diphosphatase (NUDT15) defective alleles with therapeutic drug monitoring (TDM) in Chinese patients with inflammatory bowel disease (IBD) treated with azathioprine (AZA). Azathioprine 306-318 nudix hydrolase 15 Homo sapiens 170-176 34430579-1 2021 Background: This study aimed to analyze the cost-effectiveness of combining screening for thiopurine methyl transferase (TPMT) and nucleotide triphosphate diphosphatase (NUDT15) defective alleles with therapeutic drug monitoring (TDM) in Chinese patients with inflammatory bowel disease (IBD) treated with azathioprine (AZA). Azathioprine 320-323 nudix hydrolase 15 Homo sapiens 170-176 34430579-2 2021 Methods: We evaluated the cost-effectiveness of combining screening for NUDT15 and TPMT deficiency with TDM in patients receiving AZA treatment over a 1-year horizon by developing a decision tree model. Azathioprine 130-133 nudix hydrolase 15 Homo sapiens 72-78 34430579-11 2021 Conclusions: For Chinese patients with IBD who receive an AZA regimen, a strategy involving combined NUDT15/TPMT genotype screening prior to treatment initiation and incorporating TDM for treatment management is cost-effective compared to strategies involving genotyping of NUDT15 or TPMT alone or genotyping without TDM. Azathioprine 58-61 nudix hydrolase 15 Homo sapiens 101-107 34084143-6 2021 Only the NUDT15 (415C>T) polymorphism was found to be associated with the adverse effects of azathioprine-induced myelosuppression (odds ratio (OR), 51.818; 95% CI, 5.280-508.556; p = 0.001), which suggested that the NUDT15 (415C>T) polymorphism could be an influencing factor of azathioprine-induced myelosuppression in the Chinese population. Azathioprine 93-105 nudix hydrolase 15 Homo sapiens 9-15 34084143-6 2021 Only the NUDT15 (415C>T) polymorphism was found to be associated with the adverse effects of azathioprine-induced myelosuppression (odds ratio (OR), 51.818; 95% CI, 5.280-508.556; p = 0.001), which suggested that the NUDT15 (415C>T) polymorphism could be an influencing factor of azathioprine-induced myelosuppression in the Chinese population. Azathioprine 93-105 nudix hydrolase 15 Homo sapiens 217-223 34084143-6 2021 Only the NUDT15 (415C>T) polymorphism was found to be associated with the adverse effects of azathioprine-induced myelosuppression (odds ratio (OR), 51.818; 95% CI, 5.280-508.556; p = 0.001), which suggested that the NUDT15 (415C>T) polymorphism could be an influencing factor of azathioprine-induced myelosuppression in the Chinese population. Azathioprine 280-292 nudix hydrolase 15 Homo sapiens 9-15 34084143-6 2021 Only the NUDT15 (415C>T) polymorphism was found to be associated with the adverse effects of azathioprine-induced myelosuppression (odds ratio (OR), 51.818; 95% CI, 5.280-508.556; p = 0.001), which suggested that the NUDT15 (415C>T) polymorphism could be an influencing factor of azathioprine-induced myelosuppression in the Chinese population. Azathioprine 280-292 nudix hydrolase 15 Homo sapiens 217-223 35118815-3 2022 We hypothesized that among TPMT and NUDT15 normal metabolizers, a score combining the genetically predicted expression of other proteins in the thiopurine pathway would be associated with a higher risk for azathioprine discontinuation due to myelotoxicity. Azathioprine 206-218 nudix hydrolase 15 Homo sapiens 36-42 35118815-4 2022 We conducted a retrospective cohort study of new users of azathioprine who were normal TPMT and NUDT15 metabolizers. Azathioprine 58-70 nudix hydrolase 15 Homo sapiens 96-102 35118815-12 2022 In conclusion, among patients who were TPMT and NUDT15 normal metabolizers, a score combining the predicted expression of AOX1 and NME1 was associated with an increased risk for discontinuing azathioprine due to myelotoxicity. Azathioprine 192-204 nudix hydrolase 15 Homo sapiens 48-54 34751173-0 2022 A novel NUDT15 variant identified in Caucasian TPMT wild type patients with inflammatory bowel disease and azathioprine-related myelotoxicity. Azathioprine 107-119 nudix hydrolase 15 Homo sapiens 8-14