PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17242200-2 2007 Accordingly, yeast rad18 mutants are tolerant of camptothecin (CPT), a topoisomerase I inhibitor, which induces DSBs by blocking replication. Camptothecin 49-61 E3 ubiquitin-protein ligase RAD18 Saccharomyces cerevisiae S288C 19-24 17242200-2 2007 Accordingly, yeast rad18 mutants are tolerant of camptothecin (CPT), a topoisomerase I inhibitor, which induces DSBs by blocking replication. Camptothecin 63-66 E3 ubiquitin-protein ligase RAD18 Saccharomyces cerevisiae S288C 19-24 17242200-6 2007 Concomitant deletion of Rad18 and PARP1 synergistically increased CPT sensitivity, and additional inactivation of NHEJ normalized this hypersensitivity, indicating their parallel actions. Camptothecin 66-69 E3 ubiquitin-protein ligase RAD18 Saccharomyces cerevisiae S288C 24-29 17077513-5 2006 As reported, WRNIP1-/-/- cells and RAD18-/- cells are moderately and severely sensitive to camptothecin (CPT), respectively. Camptothecin 105-108 E3 ubiquitin-protein ligase RAD18 Saccharomyces cerevisiae S288C 35-40 17077513-5 2006 As reported, WRNIP1-/-/- cells and RAD18-/- cells are moderately and severely sensitive to camptothecin (CPT), respectively. Camptothecin 91-103 E3 ubiquitin-protein ligase RAD18 Saccharomyces cerevisiae S288C 35-40