PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11956509-9	2002	In vitro, the activity of acetylcholinesterase was inhibited by 100-micromol/L irinotecan (-24.8%) and markedly reduced by 1-micromol/L physostigmine (-86.7%), whereas neither SN-38 nor camptothecin had an effect.	Camptothecin	186-198	acetylcholinesterase (Cartwright blood group)	Homo sapiens	26-46	
12049482-0	2001	The inhibition of acetylcholinesterase by irinotecan and related camptothecins: key structural properties and experimental variables.	Camptothecin	65-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38	
11334569-1	2001	Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma.	Camptothecin	47-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	327-347	
11334569-1	2001	Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma.	Camptothecin	47-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	349-353	
11334569-1	2001	Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma.	Camptothecin	61-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	327-347	
11334569-1	2001	Eleven A-ring modified hexacyclic analogues of camptothecin (CPT) containing a 1,4-oxazine ring were synthesized from 10-hydroxycamptothecin (11a) and 7-ethyl-10-hydroxycamptothecin (3) (SN-38) in four to five steps and were subjected to the biological tests such as cytotoxicity, topoisomerase I (Topo I) inhibitory activity, acetylcholinesterase (AChE) inhibition, and stability in human plasma.	Camptothecin	61-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	349-353	
16257398-8	2005	These results suggest that novel anticancer drugs could be synthesized that do not inhibit AChE, or alternatively, that novel AChE inhibitors could be designed based around the camptothecin scaffold.	Camptothecin	177-189	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130	
15772291-9	2005	These studies may allow the design of both novel camptothecin analogs that would not inhibit AChE and new AChE inhibitors derived from the camptothecin scaffold.	Camptothecin	139-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110	
12049482-3	2001	Attachment of heterocyclic and branched amino groups onto the camptothecin back-bone continues to be a strategy for the synthesis of water-soluble analogues, but this may lead to undesirable inhibition of AChE.	Camptothecin	62-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	205-209	
12049482-4	2001	In this study, we screened a range of camptothecin analogues, degradation products and metabolites for their ability to inhibit AChE.	Camptothecin	38-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132	
12049482-10	2001	Overall, our experiments reveal that nitrogenous substitutions at the permissive C-10 of the camptothecin backbone may lead to AchE inhibition, particularly if they involve a quaternary nitrogen.	Camptothecin	93-105	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131