PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21660448-8	2012	RESULTS: Our results demonstrated subtoxic concentrations of DMF sensitize HCC cells to TRAIL-induced apoptosis and induce the death receptor 5 (DR5) expression level, accompanying the generation of reactive oxygen species (ROS) and the upregulation of CHOP, GPR78, and ATF4 protein expression.	Dimethylformamide	61-64	DNA damage inducible transcript 3	Homo sapiens	253-257	
21660448-9	2012	Pretreatment with N-acetylcysteine (NAC) inhibited DMF-induced upregulation of DR5, CHOP, GPR78, and ATF4 protein expression and blocked the cotreatment-induced apoptosis.	Dimethylformamide	51-54	DNA damage inducible transcript 3	Homo sapiens	84-88	
21660448-10	2012	Furthermore, DMF-mediated sensitization of HCC cells to TRAIL was reduced by administration of a blocking antibody or small interfering RNAs for DR5, salubrinal, an inhibitor of ER stress, and the small interfering RNAs for CHOP.	Dimethylformamide	13-16	DNA damage inducible transcript 3	Homo sapiens	224-228	
21660448-12	2012	CONCLUSION: The present study demonstrates that DMF selectively enhances TRAIL-induced apoptosis by ROS-stimulated ER-stress triggering CHOP-mediated DR5 upregulation in HCC.	Dimethylformamide	48-51	DNA damage inducible transcript 3	Homo sapiens	136-140