PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25257533-3 2014 Most dioxin-like pollutants activate the aryl hydrocarbon receptor (AhR) transcription factor, which regulates xenobiotic metabolism enzymes that belong to the cytochrome P450 1A family (that includes CYP1A1 and CYP1B1). Dioxins 5-11 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 212-218 26997841-1 2015 CYP1B1 is a dioxin-inducible enzyme belonging to the cytochrome P450 superfamily. Dioxins 12-18 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 31733235-0 2020 Human CYP1B1-dependent genotoxicity of dioxin-like polychlorinated biphenyls in mammalian cells. Dioxins 39-45 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 6-12 26226543-7 2015 The structure-dependent induction of CYP1A1 and CYP1B1 gene expression in Ah-responsive MDA-MB-468 breast cancer cells by these carbazoles was similar to that observed for other dioxin-like compounds, and the magnitude of the fold induction responses for the most active halogenated carbazoles was similar to that observed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Dioxins 178-184 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 48-54 24926919-1 2014 Several of the polychlorinated biphenyls (PCBs), i.e. the dioxin-like PCBs, are known to induce the P450 enzymes CYP1A1, CYP1A2 and CYP1B1 by activating the aryl hydrocarbon receptor (Ah)-receptor. Dioxins 58-64 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 132-138 19460354-0 2009 Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Dioxins 31-37 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 99-105 20846786-3 2010 Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1. Dioxins 36-42 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 84-90 20846786-3 2010 Kaempferol or resveratrol inhibited dioxin-induced cytochrome P450 1A1 (CYP1A1) and CYP1B1 expression levels and recruitment of AHR, ERalpha and co-activators to CYP1A1 and CYP1B1. Dioxins 36-42 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 173-179 20631054-0 2010 Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes. Dioxins 64-70 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 98-104 20631054-1 2010 The aryl hydrocarbon receptor (AhR) mediates induction of CYP1A1 and CYP1B1 by 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via binding to xenobiotic-responsive elements (XREs) in their enhancer regions. Dioxins 110-116 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 69-75 20631054-2 2010 CYP1A1 and CYPIB1 were both inducible by dioxin in human MCF-7 cells. Dioxins 41-47 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 11-17 20631054-5 2010 Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter. Dioxins 0-6 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 175-181 20631054-6 2010 Because p300 was required for dioxin induction of the aforementioned histone modifications at the CYP1B1 promoter and for induction of CYP1B1 transcription (in MCF-7 cells), the recruitments of p300 and AhR, although necessary, are not sufficient for eliciting the above responses to dioxin. Dioxins 30-36 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 98-104 19736056-8 2009 CONCLUSIONS: CYP1B1 activates chemicals such as polycyclic aromatic hydrocarbons and dioxins to create oxidized, reactive intermediates, and higher gene activity has been shown for the G allele. Dioxins 85-92 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 13-19 20829355-8 2010 The Cyp1b1 and Ahrr genes require AIP expression for normal up-regulation by dioxin, whereas Cyp1a1 and Cyp1a2 do not. Dioxins 77-83 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-10 19460354-1 2009 We investigated the role of the activation function 1 (AF1) and AF2 domains of estrogen receptor alpha (ERalpha) in mediating dioxin-dependent recruitment of ERalpha to cytochrome P4501A1 (CYP1A1) and CYP1B1 in HuH-7 human hepatoma cells. Dioxins 126-132 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 201-207 19460354-2 2009 Dioxin-induced recruitment of ERalpha wildtype (ERalpha-WT) and an ERalpha AF1 deletion mutant (ERalpha-DeltaAF1), but not a transcriptional inactive AF2 mutant (ERalpha-AF2mut) to CYP1A1 and CYP1B1. Dioxins 0-6 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 192-198 19460354-4 2009 Expression of ERalpha-WT increased dioxin-induced CYP1A1 and CYP1B1-regulated reporter activity, and CYP1A1 and CYP1B1 mRNA levels. Dioxins 35-41 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 61-67 18842620-0 2009 Roles of coactivator proteins in dioxin induction of CYP1A1 and CYP1B1 in human breast cancer cells. Dioxins 33-39 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 64-70 19287966-1 2009 Cytochrome P450 (CYP) 1A1 (CYP1A1) and CYP1B1, dioxin-inducible CYP1s, are associated with carcinogenesis in extrahepatic tissues. Dioxins 47-53 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 39-45 19158084-5 2009 Trichostatin A and suberoylanilide hydroxamic acid, two broad spectrum HDAC inhibitors, blocked PAH and dioxin-mediated induction of CYP1A1 and CYP1B1 in cell lines derived from the human aerodigestive tract. Dioxins 104-110 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 144-150 19376845-0 2009 Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes. Dioxins 21-27 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 67-73 19376845-2 2009 Resveratrol (3,4,5-trihydroxystelbine) is a naturally occurring compound that has been shown in a number of studies to inhibit the induction of CYP1A1 and CYP1B1 by dioxin (2,3,7,8-tetrachloro-dibenzo-p-dioxin), but the mechanism(s) of resveratrol inhibition is controversial. Dioxins 165-171 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 155-161 19376845-3 2009 In the current study, 100nM dioxin treatment for 24, 48, and 72 h induced CYP1A1, CYP1A2, and CYP1B1 mRNA levels in the human breast cancer cell line MCF-7, and CYP1A1 and CYP1A2 mRNA levels in the human hepatocellular carcinoma cell line, HepG2. Dioxins 28-34 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 94-100 19376845-5 2009 Our studies are novel in that we used the chromatin immunoprecipitation assay to assay dioxin-induced recruitment of the aryl hydrocarbon receptor (AHR), and aryl hydrocarbon nuclear translocator (ARNT) to the enhancer regions and recruitment of RNA polymerase II to the promoter regions, of the CYP1A1 and CYP1B1 genes in their natural chromosomal settings. Dioxins 87-93 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 307-313 19255421-3 2009 Most of the effects of dioxin are attributed to its activation of the aryl hydrocarbon receptor (AHR), a transcription factor that binds to the Ah receptor nuclear translocator (ARNT) to regulate the transcription of numerous genes, including CYP1A1 and CYP1B1. Dioxins 23-29 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 254-260 18842620-1 2009 Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7. Dioxins 83-89 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 18842620-5 2009 Dioxin treatment also elicited recruitment of the transcriptional coactivators, steroid receptor coactivator 1 (SRC-1) and steroid receptor coactivator 2 (SRC-2) and p300, which possess intrinsic histone acetyltranferase activities, to both genes, whereas Brahma (BRM)/Switch 2-related gene 1 (BRG-1), a subunit of nucleosomal remodeling factors, was recruited more robustly to CYP1A1 relative to CYP1B1. Dioxins 0-6 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 397-403 18842620-7 2009 These results suggest that nucleosomal remodeling is less significant for dioxin-mediated induction of CYP1B1 than that of CYP1A1 and may be related to the more modest inducibility of the former. Dioxins 74-80 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 103-109 18842620-9 2009 These observations provide novel insights into the functional roles of the endogenous coactivators in dioxin induction of the human CYP1A1 and CYP1B1 genes in their natural chromosomal configurations. Dioxins 102-108 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 143-149 15075793-7 2004 The excess risk for exposed women with a Val CYP1B1 homo/heterozygous genotype could result from a higher exposure to activated metabolites of pesticides or dioxin-like substances. Dioxins 157-163 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 45-51 18583386-10 2008 These data identify a novel mechanism of genotoxicity for dioxin-like PCBs, as well as providing further evidence that overexpression of hCYP1B1 is a risk factor for extrahepatic carcinogenesis. Dioxins 58-64 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 137-144 16115918-1 2005 PURPOSE: Cytochrome P450 1B1 (CYP1B1), a dioxin inducible member of the CYP supergene family, is overexpressed in various human malignancies including prostate cancer. Dioxins 41-47 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 9-28 16115918-1 2005 PURPOSE: Cytochrome P450 1B1 (CYP1B1), a dioxin inducible member of the CYP supergene family, is overexpressed in various human malignancies including prostate cancer. Dioxins 41-47 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 16115918-5 2005 MSP primers covered dioxin response elements (DRE) and Sp1 sites that are important for the expression of CYP1B1. Dioxins 20-26 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 106-112 15659568-1 2005 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds. Dioxins 150-157 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 38-44 15659568-1 2005 Cytochrome P450 1A1 (CYP1A1) and 1B1 (CYP1B1) are phase I enzymes, the expression of which can be affected by many environmental compounds, including dioxins and dioxin-like compounds. Dioxins 150-156 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 38-44 15659568-11 2005 In addition, dioxin concentrations at which effects were observed in our in vitro study are about 10-fold higher than the human blood levels found in vivo, indicating that EROD activity and CYP1A1 and CYP1B1 expression in human lymphocytes might not be applicable as biomarkers of exposure to dioxin and dioxin-like compounds. Dioxins 13-19 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 201-207 15596250-9 2005 The CYP1B1*3 variant may have affected CYP1B1 expression in subjects highly and acutely exposed to dioxin at the time of the accident. Dioxins 99-105 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-10 15596250-9 2005 The CYP1B1*3 variant may have affected CYP1B1 expression in subjects highly and acutely exposed to dioxin at the time of the accident. Dioxins 99-105 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 39-45 15142886-6 2004 Our data suggest that CYP1A1- and CYP1B1-catalyzed catechol estrogen formation might play a key role in TCDD-induced oxidative damage, and resveratrol can act as a potential chemopreventive against dioxin-induced human mammary carcinogenesis by blocking the metabolic formation of the catechol estrogens and scavenging the ROS generated during their redox cycling. Dioxins 198-204 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 34-40 18583386-0 2008 Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls. Dioxins 114-120 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 53-72 18583386-6 2008 It has been demonstrated previously that hCYP1B1 is inhibited by dioxin-like PCBs, but whether or not it is uncoupled has not been investigated. Dioxins 65-71 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 41-48 18583386-7 2008 In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated. Dioxins 43-49 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 181-188 18583386-7 2008 In the current study, the ability of three dioxin-like PCBs 3,3",4,4"-tetrachlorobiphenyl, 3,3",4,4",5-pentachlorobiphenyl and 3,3",4,4",5,5"-hexachlorobiphenyl (PCB169) to inhibit hCYP1B1 and stimulate the formation of ROS in V79MZ cells (which lack endogenous CYPs) expressing hCYP1B1 was demonstrated. Dioxins 43-49 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 279-286 18849443-3 2008 Dioxins, via the arylhydrocarbon receptor (AhR), induce estrogen-metabolizing enzymes CYP1A1 and CYP1B1. Dioxins 0-7 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 17785579-2 2007 Both CYP1A genes and CYP1B1 are transcriptionally induced by the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). Dioxins 178-184 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 12902195-8 2003 MCF-10A cells were less responsive toward dioxin-like compounds and the apparent EC(50) values for CYP1A1 and CYP1B1 induction in this study were 10-100 fold higher than in MCF-7 cells. Dioxins 42-48 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 110-116 12646511-0 2003 Aryl hydrocarbon hydroxylase represents CYP1B1, and not CYP1A1, in human freshly isolated white cells: trimodal distribution of Japanese population according to induction of CYP1B1 mRNA by environmental dioxins. Dioxins 203-210 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 174-180 12646511-3 2003 The inducibility of CYP1B1 mRNA in leukocytes, defined as the ratio of CYP1B1 mRNA to the plasma concentration of dioxins, varied among the subjects. Dioxins 114-121 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-26 12646511-5 2003 The amounts of CYP1B1 mRNA in leukocytes of the intermediate and high responders were highly correlated with the plasma concentrations of dioxins (P < 0.05 and <0.01). Dioxins 138-145 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 15-21 12646511-6 2003 These results suggest that CYP1B1 with polymorphic inducibility by dioxins is involved in aromatic hydrocarbon hydroxylase activities in human lymphocytes. Dioxins 67-74 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-33 9802319-11 1998 Of particular interest is the remarkably strong expression of the recently identified dioxin inducible CYP1B1, known to be present in a wide range of malignant tumors. Dioxins 86-92 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 103-109 12376470-9 2002 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD, dioxin) induced expression of CYP1B1 in MCF-7 cells is increased by Trx-1. Dioxins 29-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 73-79 10764452-2 2000 To understand the potential underlying molecular mechanisms we studied the expressions of cytochrome P-450 genes (CYP1A1, CYP1A2, and CYP1B1 ), which are induced by dioxin, and the expressions of cytosolic receptor for dioxin, aryl hydrocarbon receptor, and its nuclear translocator, aryl hydrocarbon receptor nuclear translocator protein, in endometriotic and eutopic endometrial tissues. Dioxins 165-171 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 134-140 10764452-11 2000 CONCLUSION: We demonstrated for the first time the expression of dioxin-related transcription factors aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein and target genes CYP1A1, CYP1A2, and CYP1B1 in endometriotic tissues and stromal cells. Dioxins 65-71 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 224-230 11156691-1 2001 Cytochrome P450 1B1 (CYP1B1) is a recently cloned dioxin-inducible form of the cytochrome P450 supergene family of xenobiotic-metabolizing enzymes. Dioxins 50-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 11156691-1 2001 Cytochrome P450 1B1 (CYP1B1) is a recently cloned dioxin-inducible form of the cytochrome P450 supergene family of xenobiotic-metabolizing enzymes. Dioxins 50-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 10702233-10 2000 Furthermore, at least one of the dioxin response elements in the enhancer region is required for constitutive expression of CYP1B1. Dioxins 33-39 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 124-130 10067811-2 1999 Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen. Dioxins 34-40 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 10067811-2 1999 Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol, a potentially genotoxic catechol estrogen. Dioxins 34-40 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 10067811-3 1999 Therefore, the analysis of CYP1B1 in humans may be useful in establishing relationships between dioxin exposure and adverse health effects. Dioxins 96-102 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-33 10067811-10 1999 These data define the suitability of CYP1B1 for use as a mechanistically based biomarker in ongoing molecular epidemiological studies of human populations exposed to dioxins and related chemicals that bind the aromatic hydrocarbon receptor. Dioxins 166-173 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 37-43 9328177-1 1997 Cytochrome P4501B1 (CYP1B1) is the most recently identified member of the dioxin-inducible CYP1 family. Dioxins 74-80 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-18 9328177-1 1997 Cytochrome P4501B1 (CYP1B1) is the most recently identified member of the dioxin-inducible CYP1 family. Dioxins 74-80 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-26 9230218-1 1997 Cytochrome P450 CYP1B1 is a recently cloned dioxin-inducible form of the cytochrome P450 family of xenobiotic metabolizing enzymes. Dioxins 44-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 16-22 9744540-0 1998 Expression of CYP1B1 but not CYP1A1 by primary cultured human mammary stromal fibroblasts constitutively and in response to dioxin exposure: role of the Ah receptor. Dioxins 124-130 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 14-20