PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27240301-4	2016	Then the in vitro anti-inflammatory activity of 27 compounds were evaluated, and 9 saponins, 11 bile acids, taurine and muscone exhibited significant inhibitory activities on TNF-alpha production with IC50 values ranging from 12.34 to 147.24muM.	Saponins	83-91	tumor necrosis factor	Homo sapiens	175-184	
2530284-2	1989	The cells were then fixed and subsequently permeabilized in suspension by the detergent saponin in order to enable TNF alpha- or TNF beta-specific antibodies to enter the cells and interact with cytoplasmic TNF in producer cells.	Saponins	88-95	tumor necrosis factor	Homo sapiens	115-124	
2530284-2	1989	The cells were then fixed and subsequently permeabilized in suspension by the detergent saponin in order to enable TNF alpha- or TNF beta-specific antibodies to enter the cells and interact with cytoplasmic TNF in producer cells.	Saponins	88-95	tumor necrosis factor	Homo sapiens	115-118	
23717114-0	2012	Inhibition of TNF-alpha-mediated NF-kappaB Transcriptional Activity in HepG2 Cells by Dammarane-type Saponins from Panax ginseng Leaves.	Saponins	101-109	tumor necrosis factor	Homo sapiens	14-23	
23437404-2	2013	Alpha (alpha)-tomatine is the major saponin present in tomato (Lycopersicon esculentum) and we have previously reported that it suppresses tumor necrosis factor-alpha (TNF-alpha)-induced nuclear translocation of nuclear factor-kappa B (NF-kappaB) in androgen-independent prostate cancer PC-3 cells and also potently induces apoptosis of these cells.	Saponins	36-43	tumor necrosis factor	Homo sapiens	168-177	
21995855-9	2011	RESULTS: Three saponin fractions and two individual ginsenosides exhibited the inhibitory effects on monocyte adhesion on TNF-alpha-activated HCAECs and expression of ICAM-1 and VCAM-1 at both mRNA and protein levels in vitro.	Saponins	15-22	tumor necrosis factor	Homo sapiens	122-131	
21995855-11	2011	These inhibitory effect of saponin fractions maybe attribute partially to the suppression of the TNF-alpha-induced NF-kappaB activation.	Saponins	27-34	tumor necrosis factor	Homo sapiens	97-106	
21995855-13	2011	Among the tested saponin fractions, PDS is the most potent saponin fraction against TNF-alpha-induced monocyte adhesion as well as the expression of adhesion molecules in vitro and in vivo.	Saponins	17-24	tumor necrosis factor	Homo sapiens	84-93	
21995855-13	2011	Among the tested saponin fractions, PDS is the most potent saponin fraction against TNF-alpha-induced monocyte adhesion as well as the expression of adhesion molecules in vitro and in vivo.	Saponins	59-66	tumor necrosis factor	Homo sapiens	84-93	
21673512-3	2011	The involvement of other relevant components of the saponin-related signaling routes, such as the Tumor Necrosis Factor(TNF)-alpha, the interleukin(IL)-6 and the Nuclear Transcription Factor-kB (NF-kappaB), has been highlighted in animal cells.	Saponins	52-59	tumor necrosis factor	Homo sapiens	98-130	
20080229-3	2010	The in vitro effect of saponins on LPS-induced IL-8 and TNF-alpha mRNA level (by quantitative RT-PCR) and protein release (by ELISA) was evaluated in human THP-1 macrophages.	Saponins	23-31	tumor necrosis factor	Homo sapiens	56-65	
16271738-0	2006	Inhibition of tumor necrosis factor-alpha-induced expression of adhesion molecules in human endothelial cells by the saponins derived from roots of Platycodon grandiflorum.	Saponins	117-125	tumor necrosis factor	Homo sapiens	14-41