PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10433494-4 1999 The Ser-->Ala200 or the Ser-->Ala204 mutant forms of the alpha2A-adrenoceptor, when expressed in cells in the absence of pertussis toxin pretreatment, are two orders of magnitude more sensitive to inhibition of cyclic AMP production by (+/-)-para-octopamine and (+/-)-meta-octopamine, respectively, than cells expressing the wild-type receptor. Octopamine 242-263 adrenoceptor alpha 2A Homo sapiens 63-83 10433494-10 1999 The results emphasise the importance of the Ser200 and Ser204 residues of the alpha2A-adrenoceptor in exerting an inhibitory influence on the ability of (+/-)-para-octopamine and (+/-)-meta-octopamine respectively, to induce a receptor-agonist conformation capable of inhibiting forskolin-stimulation of cyclic AMP levels. Octopamine 153-174 adrenoceptor alpha 2A Homo sapiens 78-98 9313925-0 1997 Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor. Octopamine 44-54 adrenoceptor alpha 2A Homo sapiens 74-95 9313925-8 1997 The phenolamines, octopamine and synephrine were only able to couple the alpha 2A-adrenoceptor to a dose-dependent decrease in cyclic AMP production at concentrations up to 1 mM, with the synephrine isomers being more potent than the corresponding octopamine isomers. Octopamine 18-28 adrenoceptor alpha 2A Homo sapiens 73-94 9313925-8 1997 The phenolamines, octopamine and synephrine were only able to couple the alpha 2A-adrenoceptor to a dose-dependent decrease in cyclic AMP production at concentrations up to 1 mM, with the synephrine isomers being more potent than the corresponding octopamine isomers. Octopamine 248-258 adrenoceptor alpha 2A Homo sapiens 73-94 9313925-17 1997 Since octopamine and synephrine occur naturally in, and are co-released with catecholamines from, mammalian tissues, the results of the present study suggest that the human cloned alpha 2A-adrenoceptor can be coupled selectively by different endogenous agonists to G-protein pathways mediating the regulation of adenylyl cyclase activity. Octopamine 6-16 adrenoceptor alpha 2A Homo sapiens 180-201