PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9313925-0	1997	Selective inhibition of adenylyl cyclase by octopamine via a human cloned alpha 2A-adrenoceptor.	Octopamine	44-54	adrenoceptor alpha 2A	Homo sapiens	74-95	
10433494-4	1999	The Ser-->Ala200 or the Ser-->Ala204 mutant forms of the alpha2A-adrenoceptor, when expressed in cells in the absence of pertussis toxin pretreatment, are two orders of magnitude more sensitive to inhibition of cyclic AMP production by (+/-)-para-octopamine and (+/-)-meta-octopamine, respectively, than cells expressing the wild-type receptor.	Octopamine	242-263	adrenoceptor alpha 2A	Homo sapiens	63-83	
10433494-10	1999	The results emphasise the importance of the Ser200 and Ser204 residues of the alpha2A-adrenoceptor in exerting an inhibitory influence on the ability of (+/-)-para-octopamine and (+/-)-meta-octopamine respectively, to induce a receptor-agonist conformation capable of inhibiting forskolin-stimulation of cyclic AMP levels.	Octopamine	153-174	adrenoceptor alpha 2A	Homo sapiens	78-98	
9313925-8	1997	The phenolamines, octopamine and synephrine were only able to couple the alpha 2A-adrenoceptor to a dose-dependent decrease in cyclic AMP production at concentrations up to 1 mM, with the synephrine isomers being more potent than the corresponding octopamine isomers.	Octopamine	18-28	adrenoceptor alpha 2A	Homo sapiens	73-94	
9313925-8	1997	The phenolamines, octopamine and synephrine were only able to couple the alpha 2A-adrenoceptor to a dose-dependent decrease in cyclic AMP production at concentrations up to 1 mM, with the synephrine isomers being more potent than the corresponding octopamine isomers.	Octopamine	248-258	adrenoceptor alpha 2A	Homo sapiens	73-94	
9313925-17	1997	Since octopamine and synephrine occur naturally in, and are co-released with catecholamines from, mammalian tissues, the results of the present study suggest that the human cloned alpha 2A-adrenoceptor can be coupled selectively by different endogenous agonists to G-protein pathways mediating the regulation of adenylyl cyclase activity.	Octopamine	6-16	adrenoceptor alpha 2A	Homo sapiens	180-201