PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18654930-7 2008 Among the NHE7-binding proteins identified, CD44, a cell surface glycoprotein receptor for hyaluronate and other ligands, showed regulated interaction with NHE7. hyaluronate 91-102 CD44 molecule (Indian blood group) Homo sapiens 44-48 18690645-3 2008 The CD44 variants modified by the sialyl Lewis a and sialyl Lewis x glycotopes are expected to have dual functions, serving as ligands for vascular selectins, and simultaneously having binding activity to vascular bed hyaluronate, and are expected to figure heavily in cancer metastasis. hyaluronate 218-229 CD44 molecule (Indian blood group) Homo sapiens 4-8 15844216-2 2005 In epithelia, among other functions, the adhesion protein CD44 promotes the contact to components of the extracellular matrix like hyaluronate. hyaluronate 131-142 CD44 molecule (Indian blood group) Homo sapiens 58-62 17177600-0 2006 Hyaluronate fragments reverse skin atrophy by a CD44-dependent mechanism. hyaluronate 0-11 CD44 molecule (Indian blood group) Homo sapiens 48-52 16713618-2 2006 One molecule playing a major role in these processes is the CD44 surface receptor, which is expressed in a wide range of cells including many cells of the hemopoietic system, where it mediates the interaction with its major ligand, hyaluronate. hyaluronate 232-243 CD44 molecule (Indian blood group) Homo sapiens 60-64 10415022-5 1999 In contrast, the so-called blocking anti-CD44 mAbs (epitope group f) that can abrogate the binding of hyaluronate (HA) failed to induce apoptosis even after further cross-linking with the secondary Ab, indicating that a mere mAb-induced oligomerization of the chimeric proteins is insufficient for signal generation. hyaluronate 102-113 CD44 molecule (Indian blood group) Homo sapiens 41-45 15124536-6 2004 Effect of CD44-specific antisense oligonucleotide on adhesion of trabecular meshwork cells to hyaluronate was determined by MTT assay. hyaluronate 94-105 CD44 molecule (Indian blood group) Homo sapiens 10-14 15124536-10 2004 Adhesion of trabecular meshwork cells to hyaluronate was inhibited by CD44-specific antisense oligonucleotide. hyaluronate 41-52 CD44 molecule (Indian blood group) Homo sapiens 70-74 11121141-0 2000 Decrease in epidermal CD44 expression as a potential mechanism for abnormal hyaluronate accumulation in superficial dermis in lichen sclerosus et atrophicus. hyaluronate 76-87 CD44 molecule (Indian blood group) Homo sapiens 22-26 11121141-5 2000 In this study we provide evidence that hyaluronate is accumulated in the superficial dermis of lichen sclerosus et atrophicus lesions, in particular by the use of human CD44 receptor globulin staining, which binds specifically to hyaluronate. hyaluronate 39-50 CD44 molecule (Indian blood group) Homo sapiens 169-173 11121141-5 2000 In this study we provide evidence that hyaluronate is accumulated in the superficial dermis of lichen sclerosus et atrophicus lesions, in particular by the use of human CD44 receptor globulin staining, which binds specifically to hyaluronate. hyaluronate 230-241 CD44 molecule (Indian blood group) Homo sapiens 169-173 11121141-8 2000 These results suggest that a decrease in CD44 in the keratinocytes may be correlated with an abnormal dermal accumulation of hyaluronate in the lesions of lichen sclerosus et atrophicus, and may play a pathogenetic role in this disease. hyaluronate 125-136 CD44 molecule (Indian blood group) Homo sapiens 41-45 11320076-5 2001 CD44, the cell surface receptor for hyaluronate, was overexpressed in COX-2-S cells, and specific blockade of CD44 significantly decreased tumor cell invasion. hyaluronate 36-47 CD44 molecule (Indian blood group) Homo sapiens 0-4 11320076-5 2001 CD44, the cell surface receptor for hyaluronate, was overexpressed in COX-2-S cells, and specific blockade of CD44 significantly decreased tumor cell invasion. hyaluronate 36-47 CD44 molecule (Indian blood group) Homo sapiens 110-114 11149422-3 2001 In vitro studies showed a significantly reduced ability of the stable antisense transfectants (LS174TAS1 and LS174TAS2) to bind hyaluronate and osteopontin, ligands for CD44. hyaluronate 128-139 CD44 molecule (Indian blood group) Homo sapiens 169-173 11149422-8 2001 In vitro adhesion assays between the transfectants or controls and human peritoneal mesothelial cells revealed that the binding of LS174T cells to mesothelial cells was partly mediated by CD44-hyaluronate interaction. hyaluronate 193-204 CD44 molecule (Indian blood group) Homo sapiens 188-192 11149422-9 2001 These data suggest that CD44-hyaluronate interaction plays a crucial role in peritoneal dissemination in colorectal carcinoma. hyaluronate 29-40 CD44 molecule (Indian blood group) Homo sapiens 24-28 11464867-2 2001 CD44H is the major receptor for hyaluronate, and most if not all CD44H known functions are attributed to its ability to recognize hyaluronate. hyaluronate 32-43 CD44 molecule (Indian blood group) Homo sapiens 0-4 11464867-5 2001 PROCEDURE: In the present study we have compared the glycosylated structure of CD44 expressed by NMYC amplified vs. nonamplified cell lines in relation to their adhesive properties for hyaluronate. hyaluronate 185-196 CD44 molecule (Indian blood group) Homo sapiens 79-83 11464867-7 2001 RESULTS AND CONCLUSIONS: Our results indicate that increased sialylation, defective N-linked glycosylation, and substitution of the CD44 glycoprotein with keratan sulfate glycosaminoglycan might include modifications observed on neuroblastoma cells that could account for the inability of the receptor to bind hyaluronate. hyaluronate 310-321 CD44 molecule (Indian blood group) Homo sapiens 132-136 11426626-1 2000 Human CD34+ hematopoietic progenitor cells (HPCs) express CD44 and can directly adhere to hyaluronate (HA) via CD44. hyaluronate 90-101 CD44 molecule (Indian blood group) Homo sapiens 111-115 11003990-5 2000 The binding capacity of NK cells to a CD44 ligand, hyaluronate, was reduced by the stimulation with norepinephrine (P < 0.01). hyaluronate 51-62 CD44 molecule (Indian blood group) Homo sapiens 38-42 10699925-7 2000 HT29 transfectants expressing this mutant CD44s demonstrate an 84% reduction in growth of liver metastases, despite minimal binding to hyaluronate by the mutant CD44s. hyaluronate 135-146 CD44 molecule (Indian blood group) Homo sapiens 42-46 10199742-2 1999 METHODS: Because administration of the principal ligand of CD44, hyaluronate (HA), in soluble form, can inhibit CD44-HA interaction, we tested the effects of HA in vivo in an established model of chronic allograft rejection. hyaluronate 65-76 CD44 molecule (Indian blood group) Homo sapiens 59-63 10199742-2 1999 METHODS: Because administration of the principal ligand of CD44, hyaluronate (HA), in soluble form, can inhibit CD44-HA interaction, we tested the effects of HA in vivo in an established model of chronic allograft rejection. hyaluronate 65-76 CD44 molecule (Indian blood group) Homo sapiens 112-116 10439835-5 1999 Most studies have reported that the regulation of CD44 binding to hyaluronate results from glycosylation of variably spliced exons. hyaluronate 66-77 CD44 molecule (Indian blood group) Homo sapiens 50-54 10050880-9 1999 These results suggest that CD44 cleavage plays a critical role in an efficient cell-detachment from a hyaluronate substrate during the cell migration and consequently promotes CD44-mediated cancer cell migration. hyaluronate 102-113 CD44 molecule (Indian blood group) Homo sapiens 27-31 10050880-9 1999 These results suggest that CD44 cleavage plays a critical role in an efficient cell-detachment from a hyaluronate substrate during the cell migration and consequently promotes CD44-mediated cancer cell migration. hyaluronate 102-113 CD44 molecule (Indian blood group) Homo sapiens 176-180 10439835-6 1999 Direct hyaluronate binding studies of CD44 V4-V7 isoforms transfected into the human gastric carcinoma cell line, SC-M1, have indicated that the V4-V7 isoforms themselves, in addition to glycosylation, can alter hyaluronate binding. hyaluronate 7-18 CD44 molecule (Indian blood group) Homo sapiens 38-42 9085219-5 1997 Interestingly, we first revealed that CD44 molecules (hyaluronate receptor) on lymphocytes also participated in lymphocyte-HGF interactions and that hyaluronate anchored on the surface of HGF functioned as the ligand for CD44. hyaluronate 54-65 CD44 molecule (Indian blood group) Homo sapiens 38-42 9618391-5 1998 Despite increased expression, neither fresh nor cytokine-cultured EOS adhered to immobilized hyaluronate, a ligand for CD44. hyaluronate 93-104 CD44 molecule (Indian blood group) Homo sapiens 119-123 9143269-2 1997 A multifunctional adhesion molecule CD44 partially mediates binding of lymphocytes to the white matter by interacting with hyaluronate. hyaluronate 123-134 CD44 molecule (Indian blood group) Homo sapiens 36-40 9143269-7 1997 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate 48-59 CD44 molecule (Indian blood group) Homo sapiens 76-80 9143269-7 1997 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate 48-59 CD44 molecule (Indian blood group) Homo sapiens 117-121 9143269-7 1997 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate 48-59 CD44 molecule (Indian blood group) Homo sapiens 117-121 9143269-7 1997 Hermes-1, a monoclonal antibody recognizing the hyaluronate binding site of CD44, inhibited white matter adhesion of CD44v6-v10 and activated CD44st cells and binding of soluble hyaluronate to the CD44 transfectants. hyaluronate 178-189 CD44 molecule (Indian blood group) Homo sapiens 76-80 9143269-10 1997 (b) The only ligand of CD44 in the central nervous system (CNS) white matter is hyaluronate. hyaluronate 80-91 CD44 molecule (Indian blood group) Homo sapiens 23-27 9058839-6 1997 In binding studies sCD44 was able to adhere to hyaluronate and fibronectin, and moreover, sCD44 was able to block the binding of hyaluronate to CD44 on the cell surface and to block the binding of lymphocytes to high endothelial venules, suggesting that sCD44 retains its biological activity although it does not contain the cytoplasmic tail. hyaluronate 47-58 CD44 molecule (Indian blood group) Homo sapiens 20-24 21533413-0 1997 Hyaluronate activates tyrosine phosphorylation of cellular proteins including focal adhesion kinase via CD44 in human glioma cells. hyaluronate 0-11 CD44 molecule (Indian blood group) Homo sapiens 104-108 21533413-1 1997 To search for the signaling pathway of glioma cells relevant to its aggressive behavior, we examined hyaluronate-CD44 signaling. hyaluronate 101-112 CD44 molecule (Indian blood group) Homo sapiens 113-117 21533413-3 1997 Treatment of glioma cells with hyaluronate activated rapid and transient tyrosine phosphorylation of several proteins including p125(FAK), while neuroblastoma cells that express no detectable CD44 had no response to the treatment. hyaluronate 31-42 CD44 molecule (Indian blood group) Homo sapiens 192-196 21533413-4 1997 This hyaluronate-dependent tyrosine phosphorylation was blocked by anti-CD44 antibody, suggesting its direct mediation by CD44. hyaluronate 5-16 CD44 molecule (Indian blood group) Homo sapiens 72-76 21533413-4 1997 This hyaluronate-dependent tyrosine phosphorylation was blocked by anti-CD44 antibody, suggesting its direct mediation by CD44. hyaluronate 5-16 CD44 molecule (Indian blood group) Homo sapiens 122-126 21533413-6 1997 These results strongly suggest that hyaluronate-CD44 signaling may play a role in tumor invasion and proliferation by activation of p125(FAK) and MAP kinase in human glioma cells. hyaluronate 36-47 CD44 molecule (Indian blood group) Homo sapiens 48-52 9609138-2 1998 CD44, the principal cell-surface receptor for hyaluronate, and its numerous splice variants have been reported to play a crucial role in invasion and the metastatic process of different human neoplasms, including primary malignant melanoma (PMM). hyaluronate 46-57 CD44 molecule (Indian blood group) Homo sapiens 0-4 9614382-0 1998 Hyaluronate binding assay study of transfected CD44 V4-V7 isoforms into the human gastric carcinoma cell line SC-M1. hyaluronate 0-11 CD44 molecule (Indian blood group) Homo sapiens 47-51 9614382-2 1998 Among the numerous extracellular matrix components, hyaluronate, a CD44 ligand, is of increasing interest in relation to its role in cancer cell development and invasion. hyaluronate 52-63 CD44 molecule (Indian blood group) Homo sapiens 67-71 9614382-5 1998 The hyaluronate binding activity of V5 and V6-positive cells could be restored by pretreatment with anti-CD44 V5 and V6 monoclonal antibodies (MAbs). hyaluronate 4-15 CD44 molecule (Indian blood group) Homo sapiens 105-109 9395530-6 1997 A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface. hyaluronate 47-58 CD44 molecule (Indian blood group) Homo sapiens 76-80 9395530-6 1997 A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface. hyaluronate 47-58 CD44 molecule (Indian blood group) Homo sapiens 324-328 9395530-6 1997 A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface. hyaluronate 94-105 CD44 molecule (Indian blood group) Homo sapiens 76-80 9395530-6 1997 A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface. hyaluronate 94-105 CD44 molecule (Indian blood group) Homo sapiens 76-80 8977706-1 1996 CD44 is the major human cell surface receptor for hyaluronate and functions in a diverse range of physiological processes. hyaluronate 50-61 CD44 molecule (Indian blood group) Homo sapiens 0-4 9010911-4 1997 Osteopontin binds to naturally expressed and stably transfected CD44 in a manner that is specific, dose-dependent, inhibitable by anti-CD44 antibodies, insensitive to competition by Gly-Arg-Gly-Asp-Ser, and sensitive to competition by hyaluronate. hyaluronate 235-246 CD44 molecule (Indian blood group) Homo sapiens 64-68 9010911-6 1997 In contrast, binding of CD44 to hyaluronate mediates aggregation or attachment but not chemotaxis. hyaluronate 32-43 CD44 molecule (Indian blood group) Homo sapiens 24-28 9228671-1 1997 CD44 is the principal cell surface receptor for hyaluronate. hyaluronate 48-59 CD44 molecule (Indian blood group) Homo sapiens 0-4 8858111-0 1996 O-linked glycosylation modifies CD44 adhesion to hyaluronate in colon carcinoma cells. hyaluronate 49-60 CD44 molecule (Indian blood group) Homo sapiens 32-36 8858111-6 1996 Use of site-directed mutant CD44H cDNA transfectants demonstrated that CD44 O-linked glycosylation modulates interaction between hyaluronate and the B loop domain of CD44. hyaluronate 129-140 CD44 molecule (Indian blood group) Homo sapiens 28-32 8858111-6 1996 Use of site-directed mutant CD44H cDNA transfectants demonstrated that CD44 O-linked glycosylation modulates interaction between hyaluronate and the B loop domain of CD44. hyaluronate 129-140 CD44 molecule (Indian blood group) Homo sapiens 71-75 8858111-6 1996 Use of site-directed mutant CD44H cDNA transfectants demonstrated that CD44 O-linked glycosylation modulates interaction between hyaluronate and the B loop domain of CD44. hyaluronate 129-140 CD44 molecule (Indian blood group) Homo sapiens 71-75 8560266-3 1996 Osteopontin induces cellular chemotaxis but not homotypic aggregation, whereas the inverse is true for the interaction between CD44 and a carbohydrate ligand, hyaluronate. hyaluronate 159-170 CD44 molecule (Indian blood group) Homo sapiens 127-131 8906122-0 1996 CD44-hyaluronate interaction participates in the adherence of T-lymphocytes to gingival fibroblasts. hyaluronate 5-16 CD44 molecule (Indian blood group) Homo sapiens 0-4 8906122-4 1996 It was confirmed that PMA-activated T-lymphocytes strongly adhered to plate-coated hyaluronate and that the hyaluronate binding was clearly inhibited by the addition of OS/37, a newly established mAb specific for the hyaluronate-binding epitope on CD44. hyaluronate 108-119 CD44 molecule (Indian blood group) Homo sapiens 248-252 8906122-4 1996 It was confirmed that PMA-activated T-lymphocytes strongly adhered to plate-coated hyaluronate and that the hyaluronate binding was clearly inhibited by the addition of OS/37, a newly established mAb specific for the hyaluronate-binding epitope on CD44. hyaluronate 108-119 CD44 molecule (Indian blood group) Homo sapiens 248-252 8906122-8 1996 These results clearly demonstrated that CD44-hyaluronate interactions participated at least in part in the adhesiveness of T-lymphocytes to HGF. hyaluronate 45-56 CD44 molecule (Indian blood group) Homo sapiens 40-44 8690089-0 1996 The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily. hyaluronate 24-35 CD44 molecule (Indian blood group) Homo sapiens 108-112 8621620-0 1996 Keratan sulfate modification of CD44 modulates adhesion to hyaluronate. hyaluronate 59-70 CD44 molecule (Indian blood group) Homo sapiens 32-36 8621620-3 1996 In the current study, we have demonstrated that keratan sulfate modification of CD44 significantly modulates its ability to bind to hyaluronate. hyaluronate 132-143 CD44 molecule (Indian blood group) Homo sapiens 80-84 8621620-7 1996 Removal of keratan sulfate from CD44 greatly enhanced CD44-mediated cell adhesion to hyaluronate. hyaluronate 85-96 CD44 molecule (Indian blood group) Homo sapiens 32-36 8621620-7 1996 Removal of keratan sulfate from CD44 greatly enhanced CD44-mediated cell adhesion to hyaluronate. hyaluronate 85-96 CD44 molecule (Indian blood group) Homo sapiens 54-58 8621620-10 1996 Use of site-directed CD44H cDNA mutants with arginine changed to alanine at position 41 indicated that keratan sulfate modification of CD44 modulates hyaluronate adhesion through its B loop domain. hyaluronate 150-161 CD44 molecule (Indian blood group) Homo sapiens 21-25 8621620-10 1996 Use of site-directed CD44H cDNA mutants with arginine changed to alanine at position 41 indicated that keratan sulfate modification of CD44 modulates hyaluronate adhesion through its B loop domain. hyaluronate 150-161 CD44 molecule (Indian blood group) Homo sapiens 135-139 8769429-1 1996 I. De-adhesion from hyaluronate by shedding of CD44. hyaluronate 20-31 CD44 molecule (Indian blood group) Homo sapiens 47-51 8560266-4 1996 The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth. hyaluronate 78-89 CD44 molecule (Indian blood group) Homo sapiens 39-43 8560266-4 1996 The different responses of cells after CD44 ligation by either osteopontin or hyaluronate may account for the independent effects of CD44 on cell migration and growth. hyaluronate 78-89 CD44 molecule (Indian blood group) Homo sapiens 133-137 8570172-0 1995 CD44 hyaluronate binding influences growth kinetics and tumorigenicity of human colon carcinomas. hyaluronate 5-16 CD44 molecule (Indian blood group) Homo sapiens 0-4 8570172-6 1995 Examination of several colon carcinoma cell lines and use of mutant CD44H reveal that this in vitro and in vivo growth reduction requires the ability of CD44H to bind hyaluronate. hyaluronate 167-178 CD44 molecule (Indian blood group) Homo sapiens 68-72 8570172-6 1995 Examination of several colon carcinoma cell lines and use of mutant CD44H reveal that this in vitro and in vivo growth reduction requires the ability of CD44H to bind hyaluronate. hyaluronate 167-178 CD44 molecule (Indian blood group) Homo sapiens 153-157 7545390-0 1995 Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type. hyaluronate 42-53 CD44 molecule (Indian blood group) Homo sapiens 34-38 8750184-9 1995 We envisage that CD44 isoforms, in particular CD44s, may contribute to the invasive character of primary tumors by interacting with hyaluronate, one of the most abundant molecules in the extracellular matrix of the brain. hyaluronate 132-143 CD44 molecule (Indian blood group) Homo sapiens 17-21 8750184-9 1995 We envisage that CD44 isoforms, in particular CD44s, may contribute to the invasive character of primary tumors by interacting with hyaluronate, one of the most abundant molecules in the extracellular matrix of the brain. hyaluronate 132-143 CD44 molecule (Indian blood group) Homo sapiens 46-50 7542295-1 1995 CD44 is a principal cell-surface receptor for hyaluronate and is found on a wide variety of cells. hyaluronate 46-57 CD44 molecule (Indian blood group) Homo sapiens 0-4 7531501-2 1994 CD44 properties in vitro include hyaluronate-mediated adhesion, motility, hyaluronate degradation, self-aggregation, and adhesion to lymphoid tissue. hyaluronate 33-44 CD44 molecule (Indian blood group) Homo sapiens 0-4 9815989-2 1995 CD44 is a major receptor for hyaluronate and exists as a standard 90-180-kDa form (CD44H), as well as several higher molecular mass variant forms produced by alternative splicing. hyaluronate 29-40 CD44 molecule (Indian blood group) Homo sapiens 0-4 7528778-0 1995 Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain. hyaluronate 30-41 CD44 molecule (Indian blood group) Homo sapiens 53-57 7513749-0 1994 CD44-hyaluronate interaction mediates in vitro lymphocyte binding to the white matter of the central nervous system. hyaluronate 5-16 CD44 molecule (Indian blood group) Homo sapiens 0-4 7513749-1 1994 The cell adhesion molecule CD44 is expressed in the central nervous system, especially on glial cells in the white matter, the extracellular matrix of which also contains one of its ligands, hyaluronate. hyaluronate 191-202 CD44 molecule (Indian blood group) Homo sapiens 27-31 7513749-3 1994 Hermes-1 epitope, which recognizes the hyaluronate binding site of CD44, and Hermes-3 epitope, involved in lymphocyte binding to mucosal high endothelial venules, were both immunohistochemically expressed in the white matter. hyaluronate 39-50 CD44 molecule (Indian blood group) Homo sapiens 67-71 7537174-1 1995 CD44 is the transmembrane adhesion molecule which binds hyaluronate. hyaluronate 56-67 CD44 molecule (Indian blood group) Homo sapiens 0-4 8093047-6 1994 A putative hyaluronate (HA)-binding motif which has recently been identified in CD44 antigen existed in the extracellular domain and intracellular amino terminus of CD38 antigen. hyaluronate 11-22 CD44 molecule (Indian blood group) Homo sapiens 80-84 7515923-0 1994 Hyaluronate is costimulatory for human T cell effector functions and binds to CD44 on activated T cells. hyaluronate 0-11 CD44 molecule (Indian blood group) Homo sapiens 78-82 7515923-3 1994 Here, we show that hyaluronate (HA), a CD44 ligand, in conjunction with CD3/TCR-mediated stimuli, is costimulatory for human peripheral blood T cell proliferation, for IL-2 production by Th clones, and for release of trypsin-like esterase by cytolytic T cell clones. hyaluronate 19-30 CD44 molecule (Indian blood group) Homo sapiens 39-43 7525670-1 1994 CD44 is a widely distributed cell surface protein thought to be involved in multiple steps of normal immune cell function, including T-cell activation, and in cellular adhesion where it mediates cell attachment to hyaluronate. hyaluronate 214-225 CD44 molecule (Indian blood group) Homo sapiens 0-4 7506725-0 1994 Inducible binding of human lymphocytes to hyaluronate via CD44 does not require cytoskeleton association but does require new protein synthesis. hyaluronate 42-53 CD44 molecule (Indian blood group) Homo sapiens 58-62 7531501-2 1994 CD44 properties in vitro include hyaluronate-mediated adhesion, motility, hyaluronate degradation, self-aggregation, and adhesion to lymphoid tissue. hyaluronate 74-85 CD44 molecule (Indian blood group) Homo sapiens 0-4 8366214-1 1993 CD44 is the principal cell surface receptor for hyaluronate. hyaluronate 48-59 CD44 molecule (Indian blood group) Homo sapiens 0-4 7515731-4 1993 CD44 isoforms belong to the family of cell adhesion molecules and to the sub-family of the hyaladherins in consideration of their affinity for hyaluronate and their structural homology with the cartilage link protein. hyaluronate 143-154 CD44 molecule (Indian blood group) Homo sapiens 0-4 7515731-5 1993 The standard form of CD44, CD44H exhibits a high affinity for hyaluronate, plays a role in the uptake and degradation of this glycosaminoglycan and participates in cell locomotion in its presence. hyaluronate 62-73 CD44 molecule (Indian blood group) Homo sapiens 21-25 7515731-8 1993 The variant form CD44E exhibits low affinity for hyaluronate and its role in cell-cell adhesion in epithelia is suspected. hyaluronate 49-60 CD44 molecule (Indian blood group) Homo sapiens 17-21 1917024-3 1991 The endothelial cell surface ligand for CD44 is probably a human equivalent of MECA-367 and hyaluronate. hyaluronate 92-103 CD44 molecule (Indian blood group) Homo sapiens 40-44 1426053-1 1992 CD44 is an integral membrane glycoprotein of approximately 90 kDa which has been implicated in the binding of hyaluronate to the cell surface. hyaluronate 110-121 CD44 molecule (Indian blood group) Homo sapiens 0-4 1500863-1 1992 CD44H is the principal cell surface receptor for hyaluronate, which is a major glycosaminoglycan of the extracellular matrix. hyaluronate 49-60 CD44 molecule (Indian blood group) Homo sapiens 0-4 1500863-2 1992 Expression of CD44H is enhanced in a variety of malignant tumors and correlates with tumor aggressiveness, supporting the notion that interaction between CD44H and hyaluronate may play an important role in tumor growth and dissemination. hyaluronate 164-175 CD44 molecule (Indian blood group) Homo sapiens 14-18 1730767-5 1992 The NH2-terminal half of the predicted TSG-6 protein sequence shows a significant homology with a region implicated in hyaluronate binding, present in cartilage link protein, proteoglycan core proteins, and the adhesion receptor CD44. hyaluronate 119-130 CD44 molecule (Indian blood group) Homo sapiens 229-233 1719988-1 1991 Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis. hyaluronate 34-45 CD44 molecule (Indian blood group) Homo sapiens 47-51 1922057-2 1991 One of these genes was identified as CD44, which encodes an integral membrane glycoprotein that serves as the principal receptor for hyaluronate and participates in specific cell-cell and cell-extracellular matrix interactions. hyaluronate 133-144 CD44 molecule (Indian blood group) Homo sapiens 37-41 1380003-0 1992 CD44H regulates tumor cell migration on hyaluronate-coated substrate. hyaluronate 40-51 CD44 molecule (Indian blood group) Homo sapiens 0-4 1380003-6 1992 However, cells expressing CD44H cytoplasmic deletion mutants retain significant binding capacity to hyaluronate-coated substrate. hyaluronate 100-111 CD44 molecule (Indian blood group) Homo sapiens 26-30 1281019-14 1992 The affinity for hyaluronate can be experimentally regulated and depends on the cytoplasmic domain of CD44. hyaluronate 17-28 CD44 molecule (Indian blood group) Homo sapiens 102-106 1742741-6 1991 Homotypic aggregation of cells was increased in those cells expressing high levels of CD44, and these variants were also better able to adhere to hyaluronate substrates. hyaluronate 146-157 CD44 molecule (Indian blood group) Homo sapiens 86-90 1919439-3 1991 Recently, two isoforms of CD44 have been identified: an 80-90 kD form, which has high affinity for cell bound hyaluronate and a 150 kD form which does not mediate attachment to hyaluronate-coated surfaces. hyaluronate 110-121 CD44 molecule (Indian blood group) Homo sapiens 26-30 1919439-3 1991 Recently, two isoforms of CD44 have been identified: an 80-90 kD form, which has high affinity for cell bound hyaluronate and a 150 kD form which does not mediate attachment to hyaluronate-coated surfaces. hyaluronate 177-188 CD44 molecule (Indian blood group) Homo sapiens 26-30 28477470-5 2017 Through the specific binding of hyaluronate on hollow spheres with CD44 receptors overexpressed on cancer cells, the drug-loaded hollow spheres can be specifically delivered to target cancer cells. hyaluronate 32-43 CD44 molecule (Indian blood group) Homo sapiens 67-71 1703543-3 1990 These antibodies immunoprecipitated [3H]hyaluronate binding activity from detergent extracts of both mouse and human cells, indicating that the hyaluronate receptor is identical to CD44. hyaluronate 40-51 CD44 molecule (Indian blood group) Homo sapiens 144-164 1703543-3 1990 These antibodies immunoprecipitated [3H]hyaluronate binding activity from detergent extracts of both mouse and human cells, indicating that the hyaluronate receptor is identical to CD44. hyaluronate 40-51 CD44 molecule (Indian blood group) Homo sapiens 181-185 2193100-0 1990 Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. hyaluronate 78-89 CD44 molecule (Indian blood group) Homo sapiens 57-61 2193100-3 1990 Further investigation has now revealed that hyaluronate is a potential ligand for CD44 and that hyaluronate recognition accounts for the adhesion between B lineage hybridoma and stromal cells. hyaluronate 44-55 CD44 molecule (Indian blood group) Homo sapiens 82-86 33932413-9 2021 Combined with CD44 receptor targeting ability of hyaluronate and the merits of nanogel, the catechol modified hyaluronate nanogel exhibited as an efficient chemotherapeutic formulation of BTZ for cancer treatment. hyaluronate 110-121 CD44 molecule (Indian blood group) Homo sapiens 14-18 2246506-0 1990 IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate. hyaluronate 136-147 CD44 molecule (Indian blood group) Homo sapiens 15-20 2246506-0 1990 IL-5 induces a Pgp-1 (CD44) bright B cell subpopulation that is highly enriched in proliferative and Ig secretory activity and binds to hyaluronate. hyaluronate 136-147 CD44 molecule (Indian blood group) Homo sapiens 22-26 2246506-6 1990 It was found that IL-5-activated B cells bound strongly to hyaluronate-coated surface, and this binding was specifically inhibited by anti-Pgp-1 Ab. hyaluronate 59-70 CD44 molecule (Indian blood group) Homo sapiens 139-144 2246506-8 1990 Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells. hyaluronate 66-77 CD44 molecule (Indian blood group) Homo sapiens 14-19 2246506-8 1990 Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells. hyaluronate 66-77 CD44 molecule (Indian blood group) Homo sapiens 83-88 2246506-8 1990 Moreover, the Pgp-1 bright subset of IL-5-primed B cells binds to hyaluronate in a Pgp-1-dependent manner that suggests a potential role of Pgp-1 in the in vivo adherence and trafficking of activated B cells. hyaluronate 66-77 CD44 molecule (Indian blood group) Homo sapiens 83-88 33187133-3 2020 These dots thus prepared ( 10 nm in diameter) enabled extensive cellular interactions such as hyaluronate (HA)-mediated CD44 receptor binding, ALN-mediated bone targeting, and cRGD-mediated tumor integrin alphavbeta3 binding, thus improving their tumor targeting efficiency, especially for metastasized MDA-MB-231 tumors. hyaluronate 94-105 CD44 molecule (Indian blood group) Homo sapiens 120-124 31341151-3 2019 CD44 is a major cell surface receptor for hyaluronate and is known as a cancer stem cell marker. hyaluronate 42-53 CD44 molecule (Indian blood group) Homo sapiens 0-4 26066970-3 2015 Binding of hyaluronate to CD44 HABD induces an allosteric conformational change, which results in CD44 shedding. hyaluronate 11-22 CD44 molecule (Indian blood group) Homo sapiens 26-30 28663087-3 2017 Inspired by the CD44-mediated tumor targeting ability of hyaluronate (HA), we developed HA-coated PMN-NCs (HA-NCs) via electrostatic layer-by-layer assembly. hyaluronate 57-68 CD44 molecule (Indian blood group) Homo sapiens 16-20 26066970-3 2015 Binding of hyaluronate to CD44 HABD induces an allosteric conformational change, which results in CD44 shedding. hyaluronate 11-22 CD44 molecule (Indian blood group) Homo sapiens 98-102 26066970-4 2015 A poorly characterized epitope in human CD44 HABD is recognized by the murine monoclonal antibody MEM-85, which cross-blocks hyaluronate binding to CD44 and also induces CD44 shedding. hyaluronate 125-136 CD44 molecule (Indian blood group) Homo sapiens 40-44 26066970-4 2015 A poorly characterized epitope in human CD44 HABD is recognized by the murine monoclonal antibody MEM-85, which cross-blocks hyaluronate binding to CD44 and also induces CD44 shedding. hyaluronate 125-136 CD44 molecule (Indian blood group) Homo sapiens 148-152 26066970-4 2015 A poorly characterized epitope in human CD44 HABD is recognized by the murine monoclonal antibody MEM-85, which cross-blocks hyaluronate binding to CD44 and also induces CD44 shedding. hyaluronate 125-136 CD44 molecule (Indian blood group) Homo sapiens 148-152 26066970-9 2015 The MEM-85 epitope is situated in the C-terminal part of CD44 HABD, rather than the hyaluronate-binding groove, and the binding of MEM-85 induces a structural reorganization similar to that induced by hyaluronate. hyaluronate 201-212 CD44 molecule (Indian blood group) Homo sapiens 57-61