PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2466850-9 1989 Indeed, in many cases, the distribution of hyaluronate closely paralleled that of the hyaluronate receptor. hyaluronate 43-54 CD44 antigen Mus musculus 86-106 21179550-0 2010 Synergistic effect of hyaluronate fragments in retinaldehyde-induced skin hyperplasia which is a Cd44-dependent phenomenon. hyaluronate 22-33 CD44 antigen Mus musculus 97-101 28224886-3 2017 Hyaluronate, a main component of glycosaminoglycans, provides CD44-specific interactions with chondrocytes but typically requires chemical cross-linking agents to fabricate hydrogels, which may cause unexpected side effects in the body. hyaluronate 0-11 CD44 antigen Mus musculus 62-66 2458949-1 1988 To examine the role of the hyaluronate receptor in cell to cell adhesion, we have employed the K-3 monoclonal antibody (MAb) which specifically binds to the hyaluronate receptor and blocks its ability to interact with hyaluronate. hyaluronate 27-38 CD44 antigen Mus musculus 157-177 12183839-4 2002 Although MA-8 and another anti-CD44 antibody, IM7.8.1, blocked adhesion of hematopoietic cells to hyaluronate, adhesion to BM stroma was notably increased by these mAb, suggesting minor roles for CD44/hyaluronate interaction and the triggering of additional adhesion pathways upon CD44 engagement. hyaluronate 98-109 CD44 antigen Mus musculus 31-35 16724877-4 2006 UVA (10 J/cm(2)) or UVB (1 J/cm(2)) irradiation significantly decreased the expression of CD44 and hyaluronate in the epidermis of hairless mice after 2 h. Expression of both epidermal CD44 and hyaluronate was reconstituted within 24 h. Topical application of retinaldehyde for 3 days prior to UVA or UVB irradiation prevented the decrease of CD44 and hyaluronate expression. hyaluronate 194-205 CD44 antigen Mus musculus 90-94 11463496-4 2001 Hyaluronate (HA), a ligand of CD44, inhibited a number of lung metastases in a dose-dependent manner (0.5% HA, 3.0+/-1.1; 0.005% HA, 5.1+/-1.5; without HA, 8.6+/-1.7; N=10 for each; P<0.05, each group with HA versus the group without HA). hyaluronate 0-11 CD44 antigen Mus musculus 30-34 9399665-4 1997 CD44-mediated adhesion to immobilized hyaluronate and the binding of fluorescence-labeled hyaluronate to the cell surface were increased in positive transfectants. hyaluronate 38-49 CD44 antigen Mus musculus 0-4 11121141-3 2000 In a recent study we have observed a massive dermal accumulation of hyaluronate as a result of the in vivo selective suppression of CD44 in keratinocytes in mice expressing a keratin 5 promoter-driven CD44 anti-sense transgene. hyaluronate 68-79 CD44 antigen Mus musculus 132-136 11121141-3 2000 In a recent study we have observed a massive dermal accumulation of hyaluronate as a result of the in vivo selective suppression of CD44 in keratinocytes in mice expressing a keratin 5 promoter-driven CD44 anti-sense transgene. hyaluronate 68-79 CD44 antigen Mus musculus 201-205 9739051-2 1998 CD44 on lymphocytes that has been "activated" to bind its principal ligand hyaluronate (HA) on endothelium can mediate the primary adhesion (rolling) of lymphocytes to vascular endothelial cells under conditions of physiologic shear stress, and this interaction is used for activated T cell extravasation into an inflamed site in vivo in mice (DeGrendele, H.C., P. Estess, L.J. hyaluronate 75-86 CD44 antigen Mus musculus 0-4 10896935-5 2000 The migration assay revealed that the CD44 cleavage contributes to the Ha-Ras(Val-12)-induced migration of NIH3T3 cells on hyaluronate substrate. hyaluronate 123-134 CD44 antigen Mus musculus 38-42 10857758-5 2000 Both hyaluronate, which binds CD44, and rat IgGs are also able to inhibit the induction of NO synthesis by the inflammatory mediators. hyaluronate 5-16 CD44 antigen Mus musculus 30-34 9399665-0 1997 Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III. hyaluronate 64-75 CD44 antigen Mus musculus 33-37 9399665-4 1997 CD44-mediated adhesion to immobilized hyaluronate and the binding of fluorescence-labeled hyaluronate to the cell surface were increased in positive transfectants. hyaluronate 90-101 CD44 antigen Mus musculus 0-4 9399665-7 1997 These results indicate that glycosylation of CD44 due to GnT-III causes enhanced adhesion to hyaluronate, local tumor growth and metastatic growth in spleen, suggesting that the CD44-mediated adhesion and tumor spread can be modified through introduction of a glycosyltransferase gene. hyaluronate 93-104 CD44 antigen Mus musculus 45-49 9399665-7 1997 These results indicate that glycosylation of CD44 due to GnT-III causes enhanced adhesion to hyaluronate, local tumor growth and metastatic growth in spleen, suggesting that the CD44-mediated adhesion and tumor spread can be modified through introduction of a glycosyltransferase gene. hyaluronate 93-104 CD44 antigen Mus musculus 178-182 1703543-4 1990 In addition, one of these antibodies (KM-201 to mouse CD44) directly blocked the binding of labeled hyaluronate to the receptor and inhibited hyaluronate dependent aggregation of SV-3T3 cells. hyaluronate 100-111 CD44 antigen Mus musculus 54-58 7514542-7 1994 Hyaluronate is known as the ligand of CD44, but neither hyaluronidase treatment nor addition of excess hyaluronate to the assay system affected rosette formation. hyaluronate 0-11 CD44 antigen Mus musculus 38-42 7514542-9 1994 Anti-CD44 antibody (KM81), which recognized the hyaluronate binding site of CD44, inhibited rosette formation. hyaluronate 48-59 CD44 antigen Mus musculus 5-9 7514542-9 1994 Anti-CD44 antibody (KM81), which recognized the hyaluronate binding site of CD44, inhibited rosette formation. hyaluronate 48-59 CD44 antigen Mus musculus 76-80 7514542-10 1994 But other monoclonal antibodies against different epitopes except for the hyaluronate binding site, even those against CD44"s hyaluronate binding site, did not inhibit rosette formation. hyaluronate 126-137 CD44 antigen Mus musculus 119-123 1469058-1 1992 We previously found that the CD44 glycoprotein on some lymphocytes can mediate adhesion to hyaluronate (HA) bearing cells. hyaluronate 91-102 CD44 antigen Mus musculus 29-33 1993837-1 1991 Identification of a CD44hi population that binds specifically to hyaluronate. hyaluronate 65-76 CD44 antigen Mus musculus 20-24 1993837-3 1991 We recently demonstrated that IL-5 stimulation in vitro induces the appearance of a distinct CD44hi Ialow CD45Rlow B cell subpopulation that has aquired the ability to bind to hyaluronate (HA), one of the ligands for CD44, and that this B cell subpopulation is enriched in both proliferative and Ig-secretory responses. hyaluronate 176-187 CD44 antigen Mus musculus 93-97 1993837-3 1991 We recently demonstrated that IL-5 stimulation in vitro induces the appearance of a distinct CD44hi Ialow CD45Rlow B cell subpopulation that has aquired the ability to bind to hyaluronate (HA), one of the ligands for CD44, and that this B cell subpopulation is enriched in both proliferative and Ig-secretory responses. hyaluronate 176-187 CD44 antigen Mus musculus 217-221 9136928-0 1997 Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. hyaluronate 137-148 CD44 antigen Mus musculus 25-29 9136928-0 1997 Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation. hyaluronate 137-148 CD44 antigen Mus musculus 76-80 9136928-1 1997 CD44 is a broadly distributed polymorphic glycoprotein that serves as the principal cell-surface receptor for hyaluronate. hyaluronate 110-121 CD44 antigen Mus musculus 0-4 9136928-2 1997 Although CD44-mediated cell interaction with hyaluronate has been implicated in a variety of physiologic events, including cell-cell and cell-substrate adhesion, cell migration, proliferation, and activation, as well as hyaluronate uptake and degradation, the biologic role of CD44 in vivo in various tissues remains to be determined. hyaluronate 45-56 CD44 antigen Mus musculus 9-13 9136928-2 1997 Although CD44-mediated cell interaction with hyaluronate has been implicated in a variety of physiologic events, including cell-cell and cell-substrate adhesion, cell migration, proliferation, and activation, as well as hyaluronate uptake and degradation, the biologic role of CD44 in vivo in various tissues remains to be determined. hyaluronate 45-56 CD44 antigen Mus musculus 277-281 9136928-6 1997 Our observations indicate that two major functions of CD44 in skin are the regulation of keratinocyte proliferation in response to extracellular stimuli and the maintenance of local hyaluronate homeostasis. hyaluronate 182-193 CD44 antigen Mus musculus 54-58 7523494-11 1994 Serum with high concentrations of CD44 partially blocked the binding of one ligand, hyaluronate, to CD44-bearing hybridoma cells. hyaluronate 84-95 CD44 antigen Mus musculus 34-38 7523494-11 1994 Serum with high concentrations of CD44 partially blocked the binding of one ligand, hyaluronate, to CD44-bearing hybridoma cells. hyaluronate 84-95 CD44 antigen Mus musculus 100-104 7507884-3 1993 To examine the role of CD44 on these cells, and to ascertain its ligand, we analysed the ability of the early thymic precursor cells to bind hyaluronate (HA) which functions as a cell adhesion molecule and a ligand for CD44. hyaluronate 141-152 CD44 antigen Mus musculus 23-27 7507884-3 1993 To examine the role of CD44 on these cells, and to ascertain its ligand, we analysed the ability of the early thymic precursor cells to bind hyaluronate (HA) which functions as a cell adhesion molecule and a ligand for CD44. hyaluronate 141-152 CD44 antigen Mus musculus 219-223 8354694-9 1993 Dose-dependent inhibition of adhesion by hyaluronate and by anti-CD44 monoclonal antibody KM81 shows that CD44 is involved in the adhesive interactions between T cells and astrocytes. hyaluronate 41-52 CD44 antigen Mus musculus 106-110 1703543-4 1990 In addition, one of these antibodies (KM-201 to mouse CD44) directly blocked the binding of labeled hyaluronate to the receptor and inhibited hyaluronate dependent aggregation of SV-3T3 cells. hyaluronate 142-153 CD44 antigen Mus musculus 54-58 1703543-8 1990 Thus, CD44 appears to have at least two distinct functional domains, one for binding hyaluronate and another involved in interactions with mucosal high endothelial venules. hyaluronate 85-96 CD44 antigen Mus musculus 6-10